Diabetes breakthrough? new Two-Drug combo shows promise

NCT ID NCT05144984

Completed Disease control Sponsor: Novo Nordisk A/S Source: ClinicalTrials.gov ↗

Summary

This study tested whether adding a new experimental medicine (NNC0480-0389) to an existing diabetes drug (semaglutide) works better than either drug alone. 500 adults with type 2 diabetes received weekly injections of different drug combinations for about 41 weeks to find the most effective doses. Researchers measured changes in blood sugar, weight, and other health markers to determine if the combination offers better diabetes management.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

"Laiko" General Hospital of Athens

Athens, 11527, Greece
"Thermi" Private Hosital

Thessaloniki, 57001, Greece
AMC Community Endocrinology

Albany, New York, 12203, United States
Aarhus Universitetshospital Diabetes og Hormonsygdomme

Aarhus N, 8200, Denmark
Advanced Med Res Maumee

Maumee, Ohio, 43537, United States
Advanced Research Institute

Ogden, Utah, 84405, United States
Albert J Weisbrot

Mason, Ohio, 45040-6815, United States
Alexandra General Hospital, Therapeutic Clinic

Athens, 11528, Greece
American Clinical Trials

Buena Park, California, 90620, United States
Appalachian Clinical Res LLC

Adairsville, Georgia, 30103, United States
Arcturus HC PLC Troy Med Res

Troy, Michigan, 48098, United States
Artemis Insitute for Clin Res

Riverside, California, 92503, United States
Artemis Institute for Clin Res

San Diego, California, 92103, United States
Bajcsy-Zsilinszky Kórház

Budapest, 1106, Hungary
Brigham & Women's Hospital

Boston, Massachusetts, 02115-5804, United States
Békés Megyei Központi Kórház

Gyula, 5700, Hungary
Békés Megyei Központi Kórház - dr. Réthy Pál Tagkórház

Békéscsaba, 5600, Hungary
CCT Research

Hatboro, Pennsylvania, 19040, United States
CHC Zvezdara, Clinical department for endocrinology

Belgrade, 11000, Serbia
Capital Clin Res Ctr,LLC

Olympia, Washington, 98502, United States
Cedar-Crosse Research Center

Chicago, Illinois, 60607, United States
Center for Klinisk Metabolisk Forskning

Hellerup, 2900, Denmark
Centex Studies

Houston, Texas, 77090, United States
Centex Studies, Inc.

Houston, Texas, 77058, United States
Centex Studies, Inc._Lake Charles

Lake Charles, Louisiana, 70601, United States
Centrum Medyczne AMED Warszawa

Warsaw, 00-215, Poland
Centrum Medyczne dr Sudnik

Sokółka, 16-100, Poland
Centrum Terapii Wspolczesnej J.M. Jasnorzewska S.K.A.

Lodz, 90-338, Poland
Chattanooga Medical Research, LLC

Chattanooga, Tennessee, 37404, United States
Clin Invest Spec, Inc

Wauconda, Illinois, 60084, United States
Clinexpert Egészségügyi Szolgáltató és Kereskedelmi Kft.

Budapest, 1036, Hungary
Clinical Centre Kragujevac, Internal Diseases Clinic, Endocr

Kragujevac, 34000, Serbia
Clinical Centre Kragujevac, Internal Diseases Clinic, Endocrinology department

Kragujevac, 34000, Serbia
Clinical Neuroscience Solutions

Memphis, Tennessee, 38119, United States
Clinical Trial Res Assoc,Inc

Plantation, Florida, 33324, United States
Consano Clinical Research, LLC

Shavano Park, Texas, 78231, United States
Cotton O'Neil Diab & Endo Ctr

Topeka, Kansas, 66606, United States
Debreceni Egyetem Belgyógyászati Klinika

Debrecen, Hajdú-Bihar, 4032, Hungary
Debreceni Egyetem Klinikai Központ Belgyógyászati Klinika D épület

Debrecen, 4043, Hungary
Diabetica Sp. z o.o.

Nysa, 48-300, Poland
Diablo Clinical Research, Inc.

Walnut Creek, California, 94598, United States
EUROMEDICA Gen Clinic The/ki, Endocrin,Metabolism,Diabetes

Thessaloniki, 54645, Greece
Endo And Metab Cons

Rockville, Maryland, 20852, United States
Endocrinology, Diabetes and Metabolism Diseases Clinic

Belgrade, 11000, Serbia
Essential Medical Research LLC

Tulsa, Oklahoma, 74137, United States
First Valley Med Grp Lancaster

Lancaster, California, 93534, United States
FutureMeds Sp. z o.o.

Wroclaw, 50-088, Poland
FutureMeds Sp. z o.o. Lodz

Lodz, 91-363, Poland
Globe Badania Kliniczne Sp. z o.o.

Kłodzko, 57-300, Poland
Headlands Research - Sarasota

Sarasota, Florida, 34243, United States
Headlands Research California, LLC

Escondido, California, 92025, United States
Higashi-shinjuku clinic

Tokyo, 169-0072, Japan
Hvidovre Hospital Endokrinologisk forsknings afsnit 159

Hvidovre, 2650, Denmark
IPMC - Dr. Elizabeta Dimitrova

Petrich, 2850, Bulgaria
Iatriko Athinon 'Palaiou Falirou'

Athens, 17562, Greece
Iatriko Athinon (Athens Medical Canter)

Athens, 15125, Greece
Iatriko Psychicou Private Clinic

Athens, 115 25, Greece
Intend Research

Norman, Oklahoma, 73069, United States
Iowa Diabetes & Endo Res Ctr

West Des Moines, Iowa, 50265, United States
Juno Research, LLC

Houston, Texas, 77074, United States
Kansai Electric Power Hospital_Center for Diabetes

Osaka, 553-0003, Japan
Kaposi Mór Oktató Kórház

Kaposvár, 7400, Hungary
Krakowskie Centrum Medyczne Sp. z o.o.

Krakow, 31-501, Poland
L-MARC Research Center

Louisville, Kentucky, 40213, United States
LLC RC Medical

Novosibirsk, 630005, Russia
Lillestol Research LLC

Fargo, North Dakota, 58104, United States
MED-TIMA Kft.

Budapest, 1132, Hungary
MH Egészségügyi Központ

Budapest, 1134, Hungary
Macoupin Research Group

Gillespie, Illinois, 62033, United States
Medical center Berbatov

Yambol, 8600, Bulgaria
Medical centre - Doverie AD

Sofia, 1632, Bulgaria
Medical centre Zdrave 1 OOD

Kozloduy, 3320, Bulgaria
Medinet LLC

Saint Petersburg, 194356, Russia
Mercury Str Med Grp, PLLC

Butte, Montana, 59701, United States
Mid Hudson Med Res-New Windsor

New Windsor, New York, 12553, United States
NZOZ Vita-Diabetica Malgorzata Buraczyk

Bialystok, Podlaskie Voivodeship, 15-879, Poland
Naka Kinen Clinic_Internal medicine

Ibaraki, 311-0113, Japan
Northeast Research Institute

Jacksonville, Florida, 32204, United States
Osrodek Badan Klinicznych Clinsante

Torun, 87-100, Poland
PTE-AOK II. Belgyogyaszati Klinika es Nephrologiai Centrum

Pécs, Baranya Vármegye, 7623, Hungary
Panstwowy Instytut Medyczny Ministerstwa Spraw Wewnetrznych I Administracji

Warsaw, 02-507, Poland
Penza Regional Clinical Hospital named after N.N. Burdenko

Penza, 440026, Russia
PharmQuest Life Sciences LLC

Greensboro, North Carolina, 27408, United States
Physicians East Endocrinology

Greenville, North Carolina, 27834, United States
Piedmont Healthcare/Research

Statesville, North Carolina, 28625, United States
Pinnacle Research Group LLC

Anniston, Alabama, 36207, United States
Preferred Primary Care Physicians_Pittsburgh

Pittsburgh, Pennsylvania, 15236, United States
Premier Research Inc.

Trenton, New Jersey, 08611, United States
Prevencia - 2000 - MCOC OOD

Stara Zagora, 6000, Bulgaria
Princeton Endo Assoc

Princeton, New Jersey, 08540, United States
Progressive Medical Research

Port Orange, Florida, 32127, United States
Providence Medical Foundation

Fullerton, California, 92835, United States
Quality Research Inc

San Antonio, Texas, 78209, United States
Reyes Clinical Research, Inc

Miami, Florida, 33175, United States
SOTE ÁOK I. sz. Belgyógyászati és Onkológiai Klinika

Budapest, 1083, Hungary
SPSK nr 1 im. prof. Stanisława Szyszko Śląskiego Uniwersytetu Medycznego w Katowicach, ul. 3-go Maja 13/15 41-800 Zabrze

Zabrze, 41-800, Poland
San Fernando Valley Hlth Inst, LLC

Canoga Park, California, 91304, United States
Shahram Jacobs MD Inc.

Sherman Oaks, California, 91403, United States
Simcare Medical Research, LLC

Sugar Land, Texas, 77478, United States
Solaris Clinical Research

Meridian, Idaho, 83646, United States
South Broward Research LLC

Miramar, Florida, 33027, United States
Southwest Clinical Trials

Houston, Texas, 77074, United States
Spartanburg Medical Research

Spartanburg, South Carolina, 29303, United States
StudyMetrix Research LLC

City of Saint Peters, Missouri, 63303, United States
Synexus Clinical Research

Glendale, Arizona, 85308, United States
Szent Borbála Kórház

Tatabánya, 2800, Hungary
The Research Group of Lexington LLC

Lexington, Kentucky, 40503, United States
ToCROM Clinic

Tokyo, 160-0008, Japan
Tokyo Center Clinic

Tokyo, 103-0028, Japan
Torrance Clin Res Inst, Inc.

Lomita, California, 90717, United States
Tumen State Medical University

Tyumen, Russia, 625023, Russia
UMHAT Aleksandrovska

Sofia, 1431, Bulgaria
UMHAT Sofiamed EAD

Sofia, 1797, Bulgaria
UT Southwestern Med Cntr

Dallas, Texas, 75390-9302, United States
UnityPoint Health-Diabetes Care Center

Peoria, Illinois, 61603, United States
University Hospital of Athens ATTIKON

Athens, Attica, 12462, Greece
University of Arizona/Banner Health

Phoenix, Arizona, 85006, United States
University of North Carolina

Chapel Hill, North Carolina, 27514, United States
VIP Trials_San Antonio

San Antonio, Texas, 78230, United States
Valley Clinical Trials, Inc.

Northridge, California, 91325, United States
Valley Research

Fresno, California, 93720, United States
Vas Vármegyei Markusovszky Egyetemi Oktatókórház

Szombathely, 9700, Hungary
Velocity Clin Res Los Angeles

Los Angeles, California, 90017, United States
Velocity Clin Res-Chula Vista

Chula Vista, California, 91911, United States
Velocity Clinical Res-Dallas

Dallas, Texas, 75230, United States
Velocity Clinical Research San Diego

La Mesa, California, 91942, United States
Velocity Nova Sp. z o.o.

Staszów, Świętokrzyskie Voivodeship, 28-200, Poland
York Clinical Research LLC

Norfolk, Virginia, 23504, United States
Yoshimura clinic

Kumamoto, 861-8039, Japan

Conditions

Explore the condition pages connected to this study.

DIABETES MELLITUS, TYPE 2