New hope for pancreatic cancer: dual antibody plus targeted pill tested in major trial

NCT ID NCT07165951

Recruiting now Disease control Sponsor: Shanghai Chia Tai Tianqing Pharmaceutical Technology Development Co., Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 3 trial tests whether a new combination of drugs—TQB2868 (a dual antibody) plus anlotinib capsules—works better than standard chemotherapy for people with metastatic pancreatic cancer that has spread. About 566 participants will be randomly assigned to receive either the new combo or placebo plus chemo. The main goal is to see if the new treatment helps people live longer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: TQB2868 (a dual antibody targeting PD-L1 and TGF-beta) combined with anlotinib hydrochloride capsules
What this could lead to: If successful, this could offer a new first-line treatment option that extends survival for people with metastatic pancreatic cancer.
What could go wrong: This is an early-stage Phase 3 trial, and the combination may not improve survival over standard chemotherapy. Side effects from the dual antibody and anlotinib could be significant.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for METASTATIC PANCREATIC DUCTAL ADENOCARCINOMA are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

pancreatic ductal adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC PANCREATIC DUCTAL ADENOCARCINOMA

Contacts and locations

Locations

Affiliated Hospital of North Sichuan Medical College
NOT_YET_RECRUITING

Nanchong, Sichuan, 637000, China
Affiliated Hospital of Zunyi Medical Universityl
NOT_YET_RECRUITING

Zunyi, Guizhou, 563000, China
Anhui Provincial Cancer Hospital
NOT_YET_RECRUITING

Hefei, Anhui, 230031, China
Beijing Daxing District People'S Hospital
NOT_YET_RECRUITING

Beijing, Beijing Municipality, 102699, China
Beijing Friendship Hospital,Capital Medical University
NOT_YET_RECRUITING

Beijing, Beijing Municipality, 100050, China
Cancer Hospital Chinese Academy pf Medical Sciences
NOT_YET_RECRUITING

Langfang, Hebei, 065000, China
Daqing Oilfield General Hospital
NOT_YET_RECRUITING

Daqing, Heilongjiang, 163001, China
First Hospital of Shanxi Medical University
NOT_YET_RECRUITING

Taiyuan, Shanxi, 030045, China
Fudan University Shanghai Cancer Center
RECRUITING

Shanghai, Shanghai Municipality, 200032, China
Gansu Provincial Hospital
NOT_YET_RECRUITING

Lanzhou, Gansu, 730000, China
Guangxi Cancer Institute
NOT_YET_RECRUITING

Nanning, Guangxi, 530000, China
Guizhou Medical University Affiliated Cancer Hospital Co., LTD
NOT_YET_RECRUITING

Guiyang, Guizhou, 550001, China
Hainan general hospital
NOT_YET_RECRUITING

Haikou, Hainan, 570311, China
Harbin Medical University Cancer Hospital
NOT_YET_RECRUITING

Haerbin, Heilongjiang, 150000, China
Henan Cancer Hospital
NOT_YET_RECRUITING

Zhengzhou, Henan, 450000, China
Hubei Cancer Hospital
NOT_YET_RECRUITING

Wuhan, Hubei, 430079, China
Hunan Cancer Hospital
NOT_YET_RECRUITING

Changsha, Hunan, 410000, China
Jiangsu Province Hospital
NOT_YET_RECRUITING

Nanjing, Jiangsu, 210029, China
Jiangyin People'S Hospital
NOT_YET_RECRUITING

Jiangyin, Jiangsu, 214431, China
Jilin Cancer Hospital
NOT_YET_RECRUITING

Changchun, Jilin, 130000, China
Lanzhou University Second Hospital
NOT_YET_RECRUITING

Lanzhou, Gansu, 730030, China
Liaoning Cancer Hospital
NOT_YET_RECRUITING

Shenyang, Liaoning, 110000, China
Linyi Cancer Hospital
NOT_YET_RECRUITING

Liyi, Shandong, 276034, China
Linyi people's hospital
NOT_YET_RECRUITING

Linyi, Shandong, 276000, China
Longhua District Central Hospital
NOT_YET_RECRUITING

Shenzhen, Guangdong, 518000, China
Mengchao Hepatobiliary Hospital OF Fujian Medical University
NOT_YET_RECRUITING

Fuzhou, Fujian, 350001, China
Nanjing Drum Tower Hospital
NOT_YET_RECRUITING

Nanjing, Jiangsu, 210000, China
Nantong Tumor Hospital
NOT_YET_RECRUITING

Nantong, Jiangsu, 226361, China
Ningbo Medical Center Lihuili Hospital
NOT_YET_RECRUITING

Ningbo, Zhejiang, 315100, China
Peking University Cancer Hospital Inner Mongolia Hospital
NOT_YET_RECRUITING

Hohhot, Inner Mongolia, 10000, China
Peking University First Hospital
NOT_YET_RECRUITING

Beijing, Beijing Municipality, 100034, China
People's Hospital of Hunan Province
NOT_YET_RECRUITING

Changsha, Hunan, 410005, China
People's Hospital of Xinjiang Uygur Autonomous Region
NOT_YET_RECRUITING

Ürümqi, Xinjiang, 830000, China
Qilu Hospital of Shandong University
NOT_YET_RECRUITING

Jinan, Shandong, 250012, China
Shanghai General Hospital
NOT_YET_RECRUITING

Shanghai, Shanghai Municipality, 201620, China
Shanghai Sixth People's Hospital
NOT_YET_RECRUITING

Shanghai, Shanghai Municipality, 200233, China
Shanxi Cancer Hospital
NOT_YET_RECRUITING

Taiyuan, Shanxi, 030000, China
Shaoxing People's Hospital
NOT_YET_RECRUITING

Shaoxing, Zhejiang, 312000, China
Sichuan Cancer Hospital
NOT_YET_RECRUITING

Chengdu, Sichuan, 610041, China
Sir Run Run Shaw Hospital , affiliated with the Zhejiang University School of Medicine
NOT_YET_RECRUITING

Hangzhou, Zhejiang, 311000, China
Sun Yat-Sen University
NOT_YET_RECRUITING

Guangzhou, Guangdong, 510000, China
Sun Yat-Sen University Cancer Center
NOT_YET_RECRUITING

Guangzhou, Guangdong, 510062, China
Tangshan peopel's Hospital
NOT_YET_RECRUITING

Tangshan, Hebei, 063001, China
The Affiliated Hospital Of Medical College Qingdao University
NOT_YET_RECRUITING

Qingdao, Shandong, 266000, China
The Affiliated Hospital of Southwest Medical University
NOT_YET_RECRUITING

Luzhou, Sichuan, 646000, China
The Affiliated Hospital of Xuzhou Medical University
NOT_YET_RECRUITING

Xuzhou, Jiangsu, 221004, China
The Fifth Medical Center of Chinese People's Liberation Army General Hospital
NOT_YET_RECRUITING

Beijing, Beijing Municipality, 100071, China
The First Affiliated Hospital of Chongqing Medical University
NOT_YET_RECRUITING

Chongqing, Chongqing Municipality, 400010, China
The First Affiliated Hospital of Guangzhou Medical University
NOT_YET_RECRUITING

Guangzhou, Guangdong, 510030, China
The First Affiliated Hospital of Henan University of Science & Technology
NOT_YET_RECRUITING

Luoyang, Henan, 471000, China
The First Affiliated Hospital of Kunming Medical University
NOT_YET_RECRUITING

Kunming, Yunnan, 650000, China
The First Affiliated Hospital of Nanchang University
NOT_YET_RECRUITING

Nanchang, Jiangxi, 330006, China
The First Affiliated Hospital of Soochow University
NOT_YET_RECRUITING

Suzhou, Jiangsu, 215006, China
The First Affiliated Hospital of USTC Anhui Provincial Hospital
NOT_YET_RECRUITING

Hefei, Anhui, 230001, China
The First Affiliated Hospital of Xi 'An Jiaotong University
NOT_YET_RECRUITING

Xi'an, Shaanxi, 710061, China
The First Affiliated Hospital of Zhengzhou University
NOT_YET_RECRUITING

Zhengzhou, Henan, 450000, China
The First Hospital of China Medical University
NOT_YET_RECRUITING

Shenyang, Liaoning, 110801, China
The First Hospital of Lanzhou University
NOT_YET_RECRUITING

Lanzhou, Gansu, 730000, China
The Firstaffiliated Hospital of Xiamen University
NOT_YET_RECRUITING

Xiamen, Fujian, 361001, China
The Second Affiliated Hospital Zhejiang University School of Medicine
NOT_YET_RECRUITING

Hangzhou, Zhejiang, 310009, China
The Second Affiliated Hospital of PLA Air Force Military Medical University
NOT_YET_RECRUITING

Xi'an, Shaanxi, 710038, China
The first hospital of Jilin University
NOT_YET_RECRUITING

Changchun, Jilin, 130000, China
Tianjin Cancer Hospital Airport Hospital
NOT_YET_RECRUITING

Tianjin, Tianjin Municipality, 300300, China
Tianjin Medical University Cancer Institute & Hospital
NOT_YET_RECRUITING

Tianjin, Tianjin Municipality, 300300, China
Wenzhou Medical University Affiliated First Hospital
NOT_YET_RECRUITING

Wenzhou, Zhejiang, 325000, China
Xiangya Hospital of Central South University
RECRUITING

Changsha, Hunan, 410008, China
Xiangyang Central Hospital
NOT_YET_RECRUITING

Xiangyang, Hubei, 441021, China
Yunnan Cancer Hospital
NOT_YET_RECRUITING

Kunming, Yunnan, 650118, China
Zhongnan Hospital of Wuhan University
NOT_YET_RECRUITING

Wuhan, Hubei, 430000, China
Zhongshan Hospital
NOT_YET_RECRUITING

Shanghai, Shanghai Municipality, 200030, China
Zhongshan Hospital Xiamen University
NOT_YET_RECRUITING

Xiamen, Fujian, 361001, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.