New drug combo aims to wipe out breast cancer before surgery

NCT ID NCT05113251

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

Summary

This study is testing whether a newer targeted drug, either alone or in sequence with standard chemotherapy, works better than current standard chemotherapy when given before surgery for high-risk, early-stage HER2-positive breast cancer. It aims to see if more patients can achieve a complete disappearance of cancer in the breast and lymph nodes after treatment. The trial involves 927 participants and compares three different treatment approaches.

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Contacts and locations

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Locations

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Springdale, Arkansas, 72762, United States
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Beverly Hills, California, 90211, United States
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Glendale, California, 91204, United States
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Los Alamitos, California, 90720, United States
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Orange, California, 92868, United States
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New Haven, Connecticut, 06510, United States
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Fort Wayne, Indiana, 46804, United States
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Lexington, Kentucky, 40503, United States
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Louisville, Kentucky, 40202, United States
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Shreveport, Louisiana, 71101, United States
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Minneapolis, Minnesota, 55407, United States
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Las Vegas, Nevada, 89102, United States
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East Brunswick, New Jersey, 08816, United States
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Summit, New Jersey, 07901, United States
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Commack, New York, 11725, United States
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Durham, North Carolina, 27710, United States
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Greenville, South Carolina, 29607, United States
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Germantown, Tennessee, 38138, United States
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Nashville, Tennessee, 37203, United States
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Fort Worth, Texas, 76104, United States
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Ogden, Utah, 84405, United States
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Tacoma, Washington, 98405, United States
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Goiânia, 74000-000, Brazil
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Ijuí, 98700-000, Brazil
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Natal, 59075-740, Brazil
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Porto Alegre, 90610-000, Brazil
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Porto Alegre, 91350-200, Brazil
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São Paulo, 01221-020, Brazil
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São Paulo, 01229-010, Brazil
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Panagyurishte, 4500, Bulgaria
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Sofia, 1330, Bulgaria
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Edmonton, Alberta, T6G 1Z2, Canada
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Toronto, Ontario, M5G 1X5, Canada
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Montreal, Quebec, H4A-3J1, Canada
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Québec, Quebec, G1S 4L8, Canada
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Sherbrooke, Quebec, J1H 5N4, Canada
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Montreal, H3T 1E2, Canada
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Beijing, 100039, China
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Changsha, 410008, China
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Changsha, 410013, China
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Chongqing, 400030, China
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Guangzhou, 510060, China
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Guangzhou, 510080, China
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Guangzhou, 510700, China
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Kunming, 650118, China
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Nanning, 530021, China
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Qingdao, 266100, China
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Shanghai, 200032, China
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Shenyang, 110001, China
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Tianjin, 300060, China
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Wuhan, 430060, China
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Wuhan, 430079, China
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Zhengzhou, 450008, China
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Augsburg, 86156, Germany
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Berlin, 10117, Germany
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Erlangen, 91054, Germany
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Hamburg, 20357, Germany
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Heidelberg, 69120, Germany
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Kiel, 24105, Germany
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Leipzig, 4103, Germany
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Mönchengladbach, 41061, Germany
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München, 81377, Germany
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Münster, 48149, Germany
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Paderborn, 33098, Germany
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Tübingen, 72076, Germany
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Gūrgaon, 122001, India
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Howrah, 711103, India
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Nagpur, 440001, India
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Nashik, 422002, India
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New Delhi, 110 085, India
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New Delhi, 110029, India
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Raipur, 492001, India
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Rishikesh, 249203, India
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Surat, 395002, India
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Thiruvananthapuram, 695011, India
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Bologna, 40138, Italy
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Candiolo, 10060, Italy
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Livorno, 57100, Italy
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Milan, 20132, Italy
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Naples, 80131, Italy
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Negrar, 37024, Italy
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Padua, 35128, Italy
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Roma, 00168, Italy
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Rozzano, 20089, Italy
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Chūōku, 104-8560, Japan
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Chūōku, 862-8655, Japan
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Hidaka-shi, 350-1298, Japan
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Hiroshima, 734-8551, Japan
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Kawasaki-shi, 216-8511, Japan
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Kōtoku, 135-8550, Japan
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Nagoya, 466-8560, Japan
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Nagoya, 467-8602, Japan
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Ota-shi, 373-8550, Japan
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Shinjuku-ku, 162-8655, Japan
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Lima, 15033, Peru
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Lima, LIMA 29, Peru
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Lima, Lima 32, Peru
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Lima, LIMA 34, Peru
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Bacolod, 6100, Philippines
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Cebu City, 6000, Philippines
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Davao City, 8000, Philippines
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Iloilo City, 5000, Philippines
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Quezon City, 1112, Philippines
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San Juan City, Philippines
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Bialystok, 15-027, Poland
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Biała Podlaska, 21-500, Poland
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Bydgoszcz, 85-796, Poland
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Koszalin, 75-581, Poland
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Lublin, 20-090, Poland
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Rzeszów, 30-055, Poland
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Warsaw, 02-781, Poland
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Moscow, 117997, Russia
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Moscow, 143423, Russia
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Saint Petersburg, 190020, Russia
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Saint Petersburg, 197758, Russia
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Dammam, 31444, Saudi Arabia
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Jeddah, 21423, Saudi Arabia
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Jeddah, 23214, Saudi Arabia
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Riyadh, 11426, Saudi Arabia
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Riyadh, 3354, Saudi Arabia
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Goyang-si, 10408, South Korea
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Seoul, 03080, South Korea
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Seoul, 03722, South Korea
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Seoul, 05505, South Korea
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Seoul, 06273, South Korea
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Seoul, 06351, South Korea
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Barcelona, 08028, Spain
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Barcelona, 08035, Spain
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Madrid, 28007, Spain
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Madrid, 28040, Spain
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Seville, 41013, Spain
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Vigo, 36312, Spain
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Kaohsiung City, 82445, Taiwan
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Taichung, 40443, Taiwan
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Tainan, 710, Taiwan
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Taipei, 100, Taiwan
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Taipei, 11217, Taiwan
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Taipei, 114, Taiwan
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Taoyuan District, 333, Taiwan
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Bangkok, 10210, Thailand
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Bangkok, 10330, Thailand
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Bangkok, 10400, Thailand
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Chiang Mai, 50200, Thailand
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Hat Yai, 90110, Thailand
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Khon Kaen, 40002, Thailand

Conditions

Explore the condition pages connected to this study.

BREAST CANCER BREAST NEOPLASMS HER2-POSITIVE EARLY BREAST CANCER