New targeted drug trial offers hope for Tough-to-Treat breast cancer

NCT ID NCT05104866

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

Summary

This study is comparing a new targeted drug called Dato-DXd against standard chemotherapy for people with advanced HR-positive, HER2-negative breast cancer that has spread and worsened after one or two prior rounds of chemotherapy. The goal is to see if the new drug helps patients live longer or live longer without their cancer getting worse, while also checking its safety and impact on quality of life. About 732 participants will be randomly assigned to receive either the new drug or one of several standard chemotherapy options chosen by their doctor.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

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Duarte, California, 91010, United States
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Los Angeles, California, 90095, United States
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Palo Alto, California, 94305-5826, United States
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San Francisco, California, 94143, United States
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Jacksonville, Florida, 32207, United States
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Atlanta, Georgia, 30322, United States
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Boston, Massachusetts, 02114, United States
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Boston, Massachusetts, 02215, United States
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Grand Rapids, Michigan, 49503, United States
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New York, New York, 10065, United States
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Cleveland, Ohio, 44119, United States
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Portland, Oregon, 97239, United States
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Nashville, Tennessee, 37203, United States
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Richmond, Virginia, 23219, United States
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CABA, 1414, Argentina
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Ciudad de Buenos Aires, C1280AEB, Argentina
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La Plata, 1900, Argentina
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Mar del Plata, 7600, Argentina
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Rosario, 2000, Argentina
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Rosario, 2123, Argentina
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Anderlecht, 1070, Belgium
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Leuven, 3000, Belgium
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Liège, 4000, Belgium
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Itajaí, 88301-220, Brazil
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Jaú, 17210-070, Brazil
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Porto Alegre, 90035903, Brazil
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Ribeirão Preto, 14051-140, Brazil
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Rio de Janeiro, 20560-120, Brazil
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São Paulo, 01236-030, Brazil
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São Paulo, 01246-000, Brazil
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São Paulo, 01509-900, Brazil
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São Paulo, 1323001, Brazil
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North York, Ontario, M2K 1E1, Canada
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Toronto, Ontario, M5G 2M9, Canada
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Montreal, Quebec, H3T 1E2, Canada
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Montreal, Quebec, H4A 3J1, Canada
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Québec, Quebec, G1S 4L8, Canada
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Baoding, 071000, China
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Beijing, 100044, China
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Beijing, 100071, China
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Beijing, 100210, China
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Bengbu, 233004, China
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Changchun, 130021, China
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Changsha, 410013, China
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Chengdu, 610000, China
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Guangzhou, 510060, China
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Hangzhou, 310003, China
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Hangzhou, 310020, China
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Hangzhou, 310022, China
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Harbin, 150049, China
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Jinan, 250001, China
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Jinan, 250117, China
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Linyi, 276000, China
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Nanchang, 330006, China
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Nanchang, 330009, China
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Shanghai, 200000, China
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Tianjin, 300060, China
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Xiamen, 361003, China
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Bezannes, 51430, France
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Bordeaux, 33030, France
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Lille, 59000, France
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Lyon, 69008, France
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Montpellier, 34070, France
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Plérin, 22190, France
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Toulouse, 31059, France
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Villejuif, 94800, France
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Heidelberg, 69120, Germany
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Homburg, 66421, Germany
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Leipzig, 4103, Germany
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München, 80637, Germany
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Ravensburg, 88212, Germany
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Budapest, 1062, Hungary
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Budapest, 1122, Hungary
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Szekszárd, 7100, Hungary
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Szolnok, 5000, Hungary
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Gūrgaon, 122001, India
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Howrah, 711103, India
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Hyderabad, 500084, India
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Jaipur, 302022, India
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Kolkata, 700160, India
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Nashik, 422009, India
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Surat, 395002, India
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Visakhapatnam, 530017, India
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Bologna, 40138, Italy
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Candiolo, 10060, Italy
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Florence, 50139, Italy
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Meldola, 47014, Italy
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Milan, 20132, Italy
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Milan, 20141, Italy
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Naples, 80131, Italy
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Padua, 35128, Italy
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Prato, 59100, Italy
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Roma, 00168, Italy
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Chūōku, 104-0045, Japan
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Fukuoka, 811-1395, Japan
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Fukushima, 960-1295, Japan
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Hiroshima, 730-8518, Japan
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Isehara-shi, 259-1193, Japan
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Kagoshima, 892-0833, Japan
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Kashiwa, 227-8577, Japan
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Kitaadachi-gun, 362-0806, Japan
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Kōtoku, 135-8550, Japan
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Kyoto, 606-8507, Japan
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Matsuyama, 791-0280, Japan
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Nagoya, 464-8681, Japan
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Nishinomiya-shi, 663-8501, Japan
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Osaka, 541-8567, Japan
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Osakasayama-shi, 589-8511, Japan
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Sapporo, 003-0804, Japan
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Shinagawa-ku, 142-8666, Japan
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Shinjuku-ku, 162-8655, Japan
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Yokohama, 241-8515, Japan
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Amsterdam, 1081 HV, Netherlands
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Rotterdam, 3083 AN, Netherlands
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Venlo, 5912 BL, Netherlands
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Bialystok, 15-027, Poland
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Gdansk, 80-952, Poland
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Gdynia, 81-519, Poland
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Konin, 62-500, Poland
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Koszalin, 75-581, Poland
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Lodz, 90-302, Poland
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Tomaszów Mazowiecki, 97-200, Poland
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Warsaw, 02-781, Poland
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Moscow, 115478, Russia
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Moscow, 143423, Russia
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George, 6529, South Africa
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Johannesburg, 2013, South Africa
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Johannesburg, 2196, South Africa
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Port Elizabeth, 6045, South Africa
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Pretoria, 0081, South Africa
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Goyang-si, 10408, South Korea
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Seoul, 02841, South Korea
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Seoul, 03080, South Korea
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Seoul, 03722, South Korea
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Seoul, 05505, South Korea
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Seoul, 06351, South Korea
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Seoul, 6273, South Korea
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A Coruña, 15006, Spain
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Barcelona, 08028, Spain
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Barcelona, 8036, Spain
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Bilbao (Vizcaya), 48013, Spain
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Huelva, 21005, Spain
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L'Hospitalet de Llobregat, 08908, Spain
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Madrid, 28034, Spain
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Madrid, 28040, Spain
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Málaga, 29010, Spain
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Seville, 41013, Spain
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Valencia, 46010, Spain
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Kaohsiung City, 82445, Taiwan
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Kaohsiung City, 833, Taiwan
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Taichung, 40447, Taiwan
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Tainan, 70403, Taiwan
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Taipei, 10050, Taiwan
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Taipei, 10449, Taiwan
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Taipei, 11217, Taiwan
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Taoyuan District, 333, Taiwan
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Blackpool, FY3 8NR, United Kingdom
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Bristol, BS2 8ED, United Kingdom
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Cardiff, CF14 2TL, United Kingdom
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Colchester, CO4 5JL, United Kingdom
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Edinburgh, EH4 2XU, United Kingdom
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London, EC1A 7BE, United Kingdom
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London, SW3 6JJ, United Kingdom
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Manchester, M20 4BX, United Kingdom
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Nottingham, NG5 1PB, United Kingdom
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Sutton, SM2 5PT, United Kingdom
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Truro, TR1 3LJ, United Kingdom

Conditions

Explore the condition pages connected to this study.

BREAST CANCER