New hope for Tough-to-Treat breast cancer: targeted drug challenges chemo in major trial

NCT ID NCT05374512

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

Summary

This study is testing whether a new targeted drug called datopotamab deruxtecan (Dato-DXd) works better and is safer than standard chemotherapy for people with advanced triple-negative breast cancer who cannot receive immunotherapy. It will involve about 644 participants who have not yet received treatment for their advanced cancer. The main goals are to see if the new drug helps patients live longer without their cancer getting worse and improves their overall survival compared to chemotherapy.

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Contacts and locations

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Locations

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Duarte, California, 91010, United States
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Los Angeles, California, 90017, United States
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San Francisco, California, 94143, United States
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Grand Junction, Colorado, 81501, United States
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Longmont, Colorado, 80504, United States
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New Haven, Connecticut, 06510, United States
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Washington D.C., District of Columbia, 20010, United States
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Miami, Florida, 33170, United States
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Miami, Florida, 33176, United States
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Atlanta, Georgia, 30322, United States
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Louisville, Kentucky, 40207, United States
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Detroit, Michigan, 48201, United States
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Albuquerque, New Mexico, 87109, United States
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New York, New York, 10065, United States
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Charlotte, North Carolina, 28204, United States
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Winston-Salem, North Carolina, 27103, United States
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Providence, Rhode Island, 02903, United States
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Sioux Falls, South Dakota, 57105, United States
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Memphis, Tennessee, 38120, United States
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Nashville, Tennessee, 37203, United States
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Fort Worth, Texas, 76104, United States
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Houston, Texas, 77030, United States
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Kingwood, Texas, 77339, United States
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San Antonio, Texas, 78240, United States
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Charlottesville, Virginia, 22908, United States
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Spokane Valley, Washington, 99216, United States
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Madison, Wisconsin, 53792, United States
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Buenos Aires, 1058, Argentina
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Buenos Aires, C1125ABD, Argentina
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CABA, 1414, Argentina
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CABA, 1426, Argentina
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Ciudad Autónoma Buenos Aires, C1430EFA, Argentina
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Ciudad de Buenos Aires, 1426, Argentina
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Mar del Plata, B7600, Argentina
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Rosario, 2000, Argentina
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Anderlecht, 1070, Belgium
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Ghent, 9000, Belgium
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Namur, 5000, Belgium
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Sint-Niklaas, 9100, Belgium
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Wilrijk, 2610, Belgium
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Brasília, 71681-603, Brazil
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Curitiba, 80440-220, Brazil
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Goiânia, 74000-000, Brazil
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Jaú, 17210-120, Brazil
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Porto Alegre, 90619-900, Brazil
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Porto Alegre, 91350-200, Brazil
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Rio de Janeiro, 20560-120, Brazil
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São Paulo, 01246-000, Brazil
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São Paulo, 01321-001, Brazil
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São Paulo, 01409-001, Brazil
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Calgary, Alberta, T2N 5G2, Canada
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Barrie, Ontario, L4M 6M2, Canada
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Hamilton, Ontario, L8V 5C2, Canada
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Ottawa, Ontario, K1H 8L6, Canada
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Toronto, Ontario, M5G 2M9, Canada
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Greenfield Park, Quebec, J4V 2H1, Canada
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Montreal, Quebec, H4A 3J1, Canada
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Québec, Quebec, G1S 4L8, Canada
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Beijing, 100021, China
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Beijing, 100039, China
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Beijing, 100044, China
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Bengbu, 233004, China
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Changchun, 130021, China
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Changsha, 410008, China
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Changsha, 410013, China
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Chengdu, 610000, China
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Chongqing, 400016, China
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Guangzhou, 510060, China
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Guangzhou, 510100, China
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Hangzhou, 310003, China
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Hangzhou, 310009, China
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Hangzhou, 310022, China
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Hefei, 230031, China
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Hefei, 230601, China
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Jinan, 250001, China
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Jinan, 2501117, China
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Nanchang, 330009, China
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Nanjing, 210036, China
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Shanghai, 200025, China
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Shanghai, 201318, China
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Shenyang, 110042, China
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Shenzhen, 518020, China
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Tianjin, 300000, China
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Xi'an, 710004, China
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Xi'an, 710100, China
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Zhengzhou, 450008, China
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Zhengzhou, 450052, China
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Bordeaux, 33076, France
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Dijon, 21079, France
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Limoges, 87042, France
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Lyon, 69373, France
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Marseille, 13273, France
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Montpellier, 34298, France
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Paris, 75010, France
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Rouen, 76021, France
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Saint-Herblain, 44805, France
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Tours, 37000, France
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Aschaffenburg, 63739, Germany
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Bonn, 53111, Germany
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Frankfurt am Main, 60431, Germany
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Georgsmarienhütte, 49124, Germany
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Hanover, 30625, Germany
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Heilbronn, 74078, Germany
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Koblenz Am Rhein, 56068, Germany
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Langen, 63225, Germany
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München, 81377, Germany
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Münster, 48149, Germany
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Wiesbaden, 65199, Germany
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Budapest, 1062, Hungary
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Budapest, 1122, Hungary
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Miskolc, 3526, Hungary
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Nyíregyháza, 4400, Hungary
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Zalaegerszeg, 8900, Hungary
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Bangalore, 560004, India
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Jaipur, 302022, India
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Kolkata, 700160, India
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Nagpur, 440001, India
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Nashik, 422009, India
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New Delhi, 110085, India
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Puducherry, 605006, India
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Vadodara, 391760, India
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Borgo San Lorenzo, 50032, Italy
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Catanzaro, 88100, Italy
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Genova, 16132, Italy
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Livorno, 57126, Italy
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Macerata, 62100, Italy
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Milan, 20132, Italy
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Milan, 20141, Italy
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Modena, 41124, Italy
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Napoli, 80131, Italy
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Roma, 00137, Italy
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Rozzano, 20089, Italy
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Chūōku, 104-0045, Japan
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Fukushima, 960-1295, Japan
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Hiroshima, 730-8518, Japan
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Isehara-shi, 259-1193, Japan
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Kagoshima, 892-0833, Japan
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Kashiwa, 277-8577, Japan
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Kitaadachi-gun, 362-0806, Japan
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Kōtoku, 135-8550, Japan
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Kyoto, 606-8507, Japan
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Matsuyama, 791-0280, Japan
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Nagoya, 464-8681, Japan
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Nagoya, 466-8560, Japan
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Niigata, 951-8566, Japan
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Nishinomiya-shi, 663-8501, Japan
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Sendai, 980-8574, Japan
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Shinagawa-ku, 142-8666, Japan
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Shinjuku-ku, 162-8655, Japan
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Tsukuba, 305-8577, Japan
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Yokohama, 241-8515, Japan
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CD Mexico, 04980, Mexico
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Guadalajara, 44670, Mexico
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Guadalajara Jalisco, 44280, Mexico
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Mexico City, 0 3100, Mexico
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México, 14080, Mexico
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México, 6760, Mexico
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Bacolod, 6100, Philippines
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Cebu, 6000, Philippines
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Cebu City, 6000, Philippines
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City of Muntinlupa, 1780, Philippines
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Iloilo City, 5000, Philippines
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Quezon City, 1101, Philippines
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Quezon City, 1112, Philippines
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San Juan City, 1500, Philippines
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Bialystok, 15-027, Poland
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Bydgoszcz, 85-796, Poland
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Lodz, 93-338, Poland
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Skórzewo, 60-185, Poland
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Warsaw, 02-781, Poland
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Wroclaw, 53-413, Poland
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Bukit Merah, 169610, Singapore
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Singapore, 119074, Singapore
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Singapore, 308433, Singapore
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Cape Town, 7570, South Africa
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Johannesburg, 2196, South Africa
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Pretoria, 0002, South Africa
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Pretoria, 0081, South Africa
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Soweto, 2013, South Africa
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Busan, 602-739, South Korea
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Daegu, 41404, South Korea
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Seoul, 03080, South Korea
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Seoul, 03722, South Korea
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Seoul, 05505, South Korea
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Seoul, 06273, South Korea
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Seoul, 06351, South Korea
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Barcelona, 08028, Spain
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Barcelona, 8035, Spain
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Granada, 18016, Spain
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L'Hospitalet de Llobregat, 08908, Spain
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Madrid, 28007, Spain
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Madrid, 28034, Spain
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Madrid, 28046, Spain
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Majadahonda, 28222, Spain
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Málaga, 29010, Spain
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Santiago de Compostela, 15706, Spain
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Seville, 41013, Spain
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Hsinchu, 300, Taiwan
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Taichung, 40447, Taiwan
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Taichung, 40705, Taiwan
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Tainan, 70403, Taiwan
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Tainan, 710, Taiwan
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Taipei, 10002, Taiwan
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Taipei, 11217, Taiwan
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Taoyuan District, 00333, Taiwan
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Bangkok, 10210, Thailand
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Bangkok, 10330, Thailand
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Bangkok, 10400, Thailand
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Chiang Mai, 50200, Thailand
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Dusit, 10300, Thailand
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Hat Yai, 90110, Thailand
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Khon Kaen, 40002, Thailand
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Ankara, 06340, Turkey (Türkiye)
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Ankara, 06520, Turkey (Türkiye)
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Diyarbakır, 21280, Turkey (Türkiye)
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Istanbul, 34662, Turkey (Türkiye)
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Izmir, 35575, Turkey (Türkiye)
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Konya, 42080, Turkey (Türkiye)
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Malatya, 44280, Turkey (Türkiye)
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Bristol, BS2 8ED, United Kingdom
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Cardiff, CF14 2TL, United Kingdom
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Edinburgh, EH4 2XU, United Kingdom
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London, EC1A 7BE, United Kingdom
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London, SE1 9RT, United Kingdom
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London, SW17 0QT, United Kingdom
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Northampton, NN1 5BD, United Kingdom
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Nottingham, NG5 1PB, United Kingdom
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Warwick, CV34 5BW, United Kingdom

Conditions

Explore the condition pages connected to this study.

BREAST CANCER