Targeted drug trial offers new hope for kids with brain tumors

NCT ID NCT05566795

Recruiting now Disease control Sponsor: Day One Biopharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

Summary

This study is testing a new oral drug called tovorafenib (DAY101) against standard chemotherapy for children and young adults with a specific type of slow-growing brain tumor. The goal is to see if the new drug is more effective at shrinking tumors and controlling the disease, and if it is safer or easier to tolerate. About 400 participants worldwide will be randomly assigned to receive either the new drug or one of several standard chemotherapy options.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Aarhus Universitetshospital
RECRUITING

Aarhus, Central Jutland, 8200, Denmark
Aghia Sofia General Children's Hospital
RECRUITING

Athens, 11527, Greece
Albany Medical Center
RECRUITING

Albany, New York, 12208, United States
Alberta Children's Hospital
RECRUITING

Calgary, Alberta, T3B 6A8, Canada
Alder Hey Children's NHS Foundation Trust
RECRUITING

Liverpool, England, L12 2AP, United Kingdom
Ann & Robert H. Lurie Children's Hospital of Chicago
RECRUITING

Chicago, Illinois, 60611, United States
Arnold Palmer Hospital for Children
RECRUITING

Orlando, Florida, 32806, United States
Astrid Lindgrens Barnsjukhus Solna
RECRUITING

Stockholm, 171 77, Sweden
Athens General Children's Hospital
RECRUITING

Athens, 11527, Greece
Azienda Ospedale Università di Padova
RECRUITING

Padua, 35128, Italy
Azienda Ospedaliera U. Meyer
RECRUITING

Florence, 50139, Italy
Azienda Ospedaliera di Rilievo Nazional Santobono Pausilipon
RECRUITING

Naples, 80131, Italy
Azienda Sanitaria Universitaria Friuli Centrale - P.O. Santa Maria della Misericordia
RECRUITING

Udine, 33100, Italy
Azienda Universitaria Ospedaliera Consorziale - Policlinico di Bari
RECRUITING

Bari, 70124, Italy
Birmingham Women's and Children's NHS Foundation Trust
RECRUITING

Birmingham, England, B4 6NH, United Kingdom
British Columbia Children's Hospital
RECRUITING

Vancouver, British Columbia, V6H 3N1, Canada
CCHE
RECRUITING

Cairo, Cairo Governorate, 11441, Egypt
CHU Sainte-Justine
RECRUITING

Montreal, Quebec, H3T IC5, Canada
Cambridge University Hospitals NHS Foundation Trust
RECRUITING

Cambridge, CB2 0QQ, United Kingdom
Centre Hospitalier Universitaire Vaudois Lausanne
RECRUITING

Lausanne, 1011, Switzerland
Centre Hospitalier de l'Université Laval et Centre Mère-Enfant Soleil
RECRUITING

Québec, G1V 4G2, Canada
Centre Léon Bérard
RECRUITING

Lyon, 69008, France
Centre de Lutte contre le Cancer - Centre Oscar Lambret
RECRUITING

Lille, 59020, France
Chang Gung Memorial Hospital - Linkou Branch
RECRUITING

Taoyuan District, 333, Taiwan
Charité Universitätsmedizin Berlin
RECRUITING

Berlin, 13353, Germany
Children's Health Ireland at Crumlin
RECRUITING

Crumlin, Dublin, D12 N512, Ireland
Children's Health Queensland Hospital and Health Service
RECRUITING

South Brisbane, Queensland, 4101, Australia
Children's Healthcare of Atlanta
RECRUITING

Atlanta, Georgia, 30322, United States
Children's Hospital Colorado
RECRUITING

Aurora, Colorado, 80045, United States
Children's Hospital London Health Sciences Centre
RECRUITING

London, Ontario, N6A 5W9, Canada
Children's Hospital Los Angeles
RECRUITING

Los Angeles, California, 90027, United States
Children's Hospital at Westmead
RECRUITING

Westmead, 2145, Australia
Children's Hospital of Eastern Ontario
RECRUITING

Ottawa, Ontario, K1H 8L1, Canada
Children's Hospital of Orange County Main Campus - Orange
RECRUITING

Orange, California, 92868, United States
Children's Minnesota
RECRUITING

Minneapolis, Minnesota, 55404, United States
Children's National Medical Center
RECRUITING

Washington D.C., District of Columbia, 20010, United States
Children's of Alabama
RECRUITING

Birmingham, Alabama, 35233, United States
Childrens MS Cncr Ctr Bld Dsr
RECRUITING

Jackson, Mississippi, 39216, United States
Cleveland Clinic Main Campus
RECRUITING

Cleveland, Ohio, 44195, United States
Cliniques Universitaires Saint-Luc
RECRUITING

Brussels, 1200, Belgium
Columbia University
RECRUITING

New York, New York, 10032, United States
Connecticut Children's Medical Center
RECRUITING

Hartford, Connecticut, 06106-3322, United States
Dana-Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Dell Children's Medical Center of Central Texas
RECRUITING

Austin, Texas, 78723, United States
Drottning Silvias barn- och ungdomssjukhus
RECRUITING

Gothenburg, 416 85, Sweden
Duke Cancer Institute
RECRUITING

Durham, North Carolina, 27705, United States
Evangelische Klinikum Bethel (EvKB)
RECRUITING

Bielefeld, 33617, Germany
Fakultní Nemocnice Brno - D?tská Nemocnice
RECRUITING

Brno, 625 00, Czechia
Fondazione IRCCS - Istituto Nazionale dei Tumori
RECRUITING

Milan, Milan, 20133, Italy
Great Ormond Street Hospital for Children
RECRUITING

Oxford, England, WC1N 3JH, United Kingdom
Grupo de Apoio ao Adolescente e à Criança com Câncer (GRAACC)
RECRUITING

São Paulo, 04039-001, Brazil
Gustave Roussy
RECRUITING

Villejuif, 94805, France
Helsingin yliopistollinen sairaala (HUS)
RECRUITING

Helsinki, FI-00290, Finland
Hospital Infantil Universitario Niño Jesús
RECRUITING

Madrid, 28009, Spain
Hospital Sant Joan de Déu Barcelona
RECRUITING

Barcelona, 08950, Spain
Hospital Universitari Vall d'Hebrón
RECRUITING

Barcelona, 08035, Spain
Hospital Universitari i Politècnic La Fe
RECRUITING

Valencia, 46026, Spain
Hospital Universitario Cruces
RECRUITING

Barakaldo, 48903, Spain
Hospital Universitario La Paz
RECRUITING

Madrid, 28046, Spain
Hospital Universitario Virgen del Rocío
RECRUITING

Seville, 41013, Spain
Hôpital de la Timone
RECRUITING

Marseille, 13005, France
Institut Curie
RECRUITING

Paris, 75248, France
Istituto Giannina Gaslini
RECRUITING

Genova, 16147, Italy
Johns Hopkins All Children's Hospital
RECRUITING

St. Petersburg, Florida, 33701, United States
King Hussein Cancer Foundation - King Hussein Cancer Center
RECRUITING

Amman, Muhafazat al-Asima, 11941, Jordan
Leeds Teaching Hospital NHS Trust
RECRUITING

Leeds, England, LS1 3EX, United Kingdom
Maine Children's Cancer Program
RECRUITING

Scarborough, Maine, 04074, United States
Manchester University NHS Foundation Trust
RECRUITING

Manchester, England, M13 PWL, United Kingdom
McMaster Children's Hospital
RECRUITING

Hamilton, Ontario, L8S 4L8, Canada
Medizinische Hochschule Hannover
RECRUITING

Hanover, Lower Saxony, 30625, Germany
Medizinische Universität Innsbruck
RECRUITING

Innsbruck, Tyrol, 6020, Austria
Medizinische Universität Wien
RECRUITING

Vienna, 1090, Austria
Motol University Hospital
RECRUITING

Prague, 5 150 06, Czechia
NHS Greater Glasgow and Clyde
RECRUITING

Glasgow, Scotland, G51 4TF, United Kingdom
New York University Langone Health
RECRUITING

New York, New York, 10016, United States
Nicklaus Children's Hospital
RECRUITING

Miami, Florida, 33155, United States
Norton Children's Hospital
RECRUITING

Louisville, Kentucky, 40202, United States
Oregon Health Science University
RECRUITING

Portland, Oregon, 97239, United States
Oslo Universitetssykehus
RECRUITING

Oslo, 372, Norway
Ospedale Infantile Regina Margherita
RECRUITING

Torino, Turin, 10126, Italy
Ospedale Pediatrico Bambino Gesù
RECRUITING

Roma, Rome, 00165, Italy
Packard Children's Hospital Stanford
RECRUITING

Palo Alto, California, 94304, United States
Perth Children's Hospital
RECRUITING

Nedlands, 6009, Australia
Phoenix Children's Hospital
RECRUITING

Phoenix, Arizona, 85016, United States
Prinses Maxima Centrum Kinderoncologie
RECRUITING

Utrecht, 3584 CS, Netherlands
Rigshospitalet
RECRUITING

Copenhagen, 2100, Denmark
Riley Hospital for Children at Indiana University Health
RECRUITING

Indianapolis, Indiana, 46202, United States
Royal Belfast Hospital for Sick Children
RECRUITING

Belfast, Northern Ireland, BT9 7AB, United Kingdom
Schneider Children's Medical Center of Israel
RECRUITING

Petah Tikva, 49202, Israel
Seattle Children's Hospital
RECRUITING

Seattle, Washington, 98105, United States
Semmelweis Egyetem Tűzoltó utcai II. Sz. Gyermekgyógyászati Kliniká
RECRUITING

Budapest, 1094, Hungary
Seoul National University Hospital
RECRUITING

Seoul, 03080, South Korea
Severance Hospital
RECRUITING

Seoul, 03722, South Korea
Sheffield Children's Hospital
RECRUITING

Sheffield, South Yorkshire, S10 2TH, United Kingdom
SickKids - The Hospital for Sick Children
RECRUITING

Toronto, M5G 1X8, Canada
Sidra Medicine
RECRUITING

Doha, 26999, Qatar
SingHealth Group - KK Women's and Children's Hospital
RECRUITING

Singapore, 229899, Singapore
Skånes Universitetssjukhus - Lund
RECRUITING

Lund, 221 85, Sweden
St. Louis Children's Hospital
RECRUITING

St Louis, Missouri, 63110, United States
Starship Paediatric Blood & Cancer Center
RECRUITING

Grafton, 1023, New Zealand
Stollery Children's Hospital
RECRUITING

Edmonton, Alberta, T6G 2B7, Canada
Sydney Children's Hospital - Randwick
RECRUITING

Randwick, 2031, Australia
Taipei Medical University Hospital
RECRUITING

Taipei, 110, Taiwan
Tampereen Yliopistollinen Sairaala
RECRUITING

Tampere, 33520, Finland
Texas Children's Hospital
RECRUITING

Houston, Texas, 77030, United States
The Christie Hospital
RECRUITING

Manchester, M20 4BX, United Kingdom
The Edmond and Lily Safra Children's Hospital
RECRUITING

Ramat Gan, 5265601, Israel
The Montreal Children's Hospital
RECRUITING

Montreal, Quebec, H4A 3J1, Canada
The Newcastle Upon Tyne Hospitals NHS Foundation Trust
RECRUITING

Newcastle upon Tyne, England, NE1 4LP, United Kingdom
The Royal Children's Hospital - Children's Cancer Centre
RECRUITING

Parkville, 3052, Australia
The Royal Marsden NHS Foundation Trust
RECRUITING

Sutton, Surrey, SM2 5PT, United Kingdom
UCSF Benioff Children's Hospital
RECRUITING

San Francisco, California, 94158, United States
Universitaets - Kinderspital Zürich
RECRUITING

Zurich, 8032, Switzerland
Universitaetsklinikum Essen
RECRUITING

Essen, North Rhine-Westphalia, 45147, Germany
Universitair Ziekenhuis Gent
RECRUITING

Ghent, 9000, Belgium
Universitair Ziekenhuis Leuven - Campus Gasthuisberg
RECRUITING

Leuven, 3000, Belgium
Universitetssykehuset Nord-Norge - Tromsø
RECRUITING

Tromsø, Troms, 9038, Norway
University Hospital Southampton NHS Foundation Trust
RECRUITING

Southampton, Hampshire, SO16 6YD, United Kingdom
University Hospitals Bristol and Weston NHS Foundation Trust
RECRUITING

Bristol, BS2 8HW, United Kingdom
University of Chicago
RECRUITING

Chicago, Illinois, 60637, United States
University of Florida Health
RECRUITING

Gainesville, Florida, 32610, United States
University of Iowa Hospitals Clinics
RECRUITING

Iowa City, Iowa, 52242, United States
University of Michigan - - C.S. Mott Children's Hospital
RECRUITING

Ann Arbor, Michigan, 48109, United States
University of Nebraska Medical Center
RECRUITING

Omaha, Nebraska, 68198-6878, United States
University of Rochester
RECRUITING

Rochester, New York, 14642, United States
University of Texas Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States
University of Wisconsin - Madison
RECRUITING

Madison, Wisconsin, 53792, United States
Universitätsklinikum Augsburg
RECRUITING

Augsburg, Bavaria, 86156, Germany
Universitätsklinikum Erlangen
RECRUITING

Erlangen, Bavaria, 91054, Germany
Universitätsklinikum Frankfurt
RECRUITING

Frankfurt am Main, Hesse, 60590, Germany
Universitätsklinikum Freiburg
RECRUITING

Freiburg im Breisgau, Baden-Wurttemberg, 79106, Germany
Universitätsklinikum Hamburg-Eppendorf
RECRUITING

Hamburg, 20246, Germany
Universitätsklinikum Heidelberg
RECRUITING

Heidelberg, 69120, Germany
Universitätsklinikum Leipzig
RECRUITING

Leipzig, Saxony, 4103, Germany
Universitätsklinikum Tübingen
RECRUITING

Tübingen, 72076, Germany
Universitätsklinikum Würzburg
RECRUITING

Würzburg, Bavaria, 97080, Germany
Univerzitetni Klinini Center Ljubljana
RECRUITING

Ljubljana, 1000, Slovenia
Women's and Children's Health Network
RECRUITING

North Adelaide, 5006, Australia

Conditions

Explore the condition pages connected to this study.

LOW-GRADE GLIOMA PEDIATRIC LOW-GRADE GLIOMA RAPIDLY ACCELERATED FIBROSARCOMA (RAF) ALTERED GLIOMA