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Smart bombs for lung cancer: new ADC drugs enter trial

NCT ID NCT06780098

Recruiting now Disease control Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 10, 2026 · Updated 3 times

Summary

This phase 2 trial tests two antibody-drug conjugates (ADCs) — R-DXD and I-DXD — against standard chemotherapy in 144 people with advanced squamous non-small cell lung cancer that has worsened after initial treatment. ADCs are like guided missiles that deliver a cancer-killing drug directly to tumor cells. The study measures how many tumors shrink and how safe the treatments are.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Raludotatug deruxtecan and Ifinatamab deruxtecan (antibody-drug conjugates)
What this could lead to
If successful, these antibody-drug conjugates could offer a new treatment option for people with advanced squamous lung cancer that has stopped responding to standard therapies.
What could go wrong
This is a phase 2 trial with only 144 participants, so results are preliminary. The treatments may not work better than chemotherapy and could cause side effects like infusion reactions or organ damage.

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Conditions

The condition(s) this trial relates to.

lung neoplasm non-small cell squamous lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LUNG NEOPLASM

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Ankara Bilkent Şehir Hastanesi. ( Site 0142)

    RECRUITING

    Ankara, 06800, Turkey (Türkiye)

  • Azienda Ospedaliera Universitaria Careggi ( Site 0173)

    RECRUITING

    Florence, 50134, Italy

  • Bacs-Kiskun Varmegyei Oktatokorhaz ( Site 0063)

    RECRUITING

    Kecskemét, Bács-Kiskun county, 6000, Hungary

  • Baskent University Dr. Turgut Noyan Research and Training Center-ONCOLOGY ( Site 0141)

    RECRUITING

    Adana, 01250, Turkey (Türkiye)

  • Beijing Cancer Hospital ( Site 0301)

    RECRUITING

    Beijing, Beijing Municipality, 100142, China

  • Bradfordhill ( Site 0162)

    RECRUITING

    Santiago, Region M. de Santiago, 8420383, Chile

  • Centro de Estudios Clínicos SAGA ( Site 0161)

    RECRUITING

    Santiago, Region M. de Santiago, 7500653, Chile

  • Charite-Universitaetsmedizin Berlin ( Site 0191)

    RECRUITING

    Berlin, 13353, Germany

  • Chongqing University Cancer Hospital ( Site 0304)

    RECRUITING

    Chongqing, Chongqing Municipality, 400030, China

  • EVANGELISMOS S.A ( Site 0206)

    RECRUITING

    Athens, Attica, 106 76, Greece

  • Ege Universitesi Hastanesi ( Site 0143)

    RECRUITING

    Izmir, İzmir, 35100, Turkey (Türkiye)

  • European Interbalkan Medical Center-Oncology Department ( Site 0205)

    RECRUITING

    Thessaloniki, 570 01, Greece

  • FALP ( Site 0160)

    RECRUITING

    Santiago, Region M. de Santiago, 7500921, Chile

  • Fondazione IRCCS Istituto Nazionale dei Tumori ( Site 0175)

    RECRUITING

    Milan, 20133, Italy

  • Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore ( Site 0174)

    RECRUITING

    Roma, 00168, Italy

  • Fujian Provincial Cancer Hospital ( Site 0310)

    RECRUITING

    Fuzhou, Fujian, 350014, China

  • Guangxi Medical University Cancer Hospital ( Site 0303)

    RECRUITING

    Nanning, Guangxi, 530201, China

  • Hacettepe Universitesi Tip Fakultesi Hastanesi ( Site 0140)

    RECRUITING

    Ankara, 06230, Turkey (Türkiye)

  • Henan Cancer Hospital ( Site 0311)

    RECRUITING

    Zhengzhou, Henan, 450000, China

  • Hospital Clinic de Barcelona ( Site 0092)

    RECRUITING

    Barcelona, 08008, Spain

  • Hospital Universitario Quiron Madrid ( Site 0091)

    RECRUITING

    Madrid, 28223, Spain

  • Institut Català d'Oncologia - L'Hospitalet ( Site 0090)

    RECRUITING

    L'Hospitalet de Llobregat, Barcelona, 08908, Spain

  • Istanbul Universitesi Cerrahpasa Tip Fakultesi ( Site 0144)

    RECRUITING

    Istanbul, 34098, Turkey (Türkiye)

  • Jasz-Nagykun-Szolnok Varmegyei Hetenyi Geza Korhaz-Rendelointezet ( Site 0061)

    RECRUITING

    Szolnok, Jász-Nagykun-Szolnok, 5000, Hungary

  • MedStar Franklin Square Medical Center ( Site 0033)

    RECRUITING

    Baltimore, Maryland, 21237, United States

  • Meir Medical Center ( Site 0071)

    RECRUITING

    Kfar Saba, 4428164, Israel

  • Nanjing Drum Tower Hospital JiangBei International Branch Hospital ( Site 0309)

    RECRUITING

    Nanjing, Jiangsu, 210031, China

  • Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie ( Site 0151)

    RECRUITING

    Warsaw, Masovian Voivodeship, 02-781, Poland

  • Ospedale San Raffaele. ( Site 0171)

    RECRUITING

    Milan, 20132, Italy

  • Petz Aladar Egyetemi Oktato Korhaz ( Site 0062)

    RECRUITING

    Győr, Győr-Moson-Sopron, 9024, Hungary

  • Rabin Medical Center ( Site 0074)

    RECRUITING

    Petah Tikva, 4941492, Israel

  • Rambam Health Care Campus ( Site 0076)

    RECRUITING

    Haifa, 3109601, Israel

  • Shaare Zedek Medical Center ( Site 0075)

    RECRUITING

    Jerusalem, 9103102, Israel

  • Shanghai Chest Hospital ( Site 0308)

    RECRUITING

    Shanghai, Shanghai Municipality, 200030, China

  • Shanghai Pulmonary Hospital ( Site 0300)

    RECRUITING

    Shanghai, Shanghai Municipality, 200433, China

  • Sheba Medical Center ( Site 0070)

    RECRUITING

    Ramat Gan, 5265601, Israel

  • Sourasky Medical Center ( Site 0077)

    RECRUITING

    Tel Aviv, 6423906, Israel

  • Szpital Wojewódzki im. Mikoaja Kopernika w Koszalinie ( Site 0152)

    RECRUITING

    Koszalin, West Pomeranian Voivodeship, 75-581, Poland

  • THORACIC GENERAL HOSPITAL OF ATHENS "I SOTIRIA" ( Site 0204)

    RECRUITING

    Athens, Attica, 115 27, Greece

  • Texas Oncology - DFW ( Site 8003)

    RECRUITING

    Dallas, Texas, 75246-2046, United States

  • UniversitaetsklInikum Tuebingen ( Site 0192)

    RECRUITING

    Tübingen, Baden-Wurttemberg, 72076, Germany

  • University of Kentucky Chandler Medical Center ( Site 0019)

    RECRUITING

    Lexington, Kentucky, 40536-0293, United States

  • Uniwersyteckie Centrum Kliniczne-Early Clinical Trials Unit ( Site 0150)

    RECRUITING

    Gdansk, Pomeranian Voivodeship, 80-214, Poland

  • Wielkopolskie Centrum Pulmonologii i Torakochirurgii ( Site 0153)

    RECRUITING

    Poznan, Greater Poland Voivodeship, 60-569, Poland

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