Lung cancer mRNA vaccine trial pulled before it began
NCT ID NCT07073183
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-stage study aimed to test a new mRNA vaccine (CVHNLC) combined with the immunotherapy drug pembrolizumab in people with advanced squamous non-small-cell lung cancer. The trial was designed to find a safe dose and see if the combination could shrink tumors. However, the study was withdrawn before any participants were enrolled, so no results are available.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- CVHNLC mRNA vaccine plus pembrolizumab
- What this could lead to
- If successful, this could point toward a new treatment option for advanced squamous lung cancer by combining an mRNA vaccine with immunotherapy.
- What could go wrong
- This trial was withdrawn before enrolling any participants, so no data are available. Early-phase cancer vaccine studies often fail to show benefit or have safety issues.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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AP-HM - Hôpital Nord
Marseille, France
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CHU de Rennes - Hôpital Pontchaillou
Rennes, France
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Gustave Roussy
Villejuif, France
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Hospital Quironsalud Barcelona -NEXT Oncology
Barcelona, Spain, Spain
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Hospital Regional Universitario Virgen de la Victoria
Málaga, Spain, Spain
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Hospital Universitari Vall d´Hebron -Instituto de Investigacion Oncologica Vall dHebron (VHIO)
Barcelona, Spain, Spain
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Hospital Universitario Fundacion Jimenez Diaz - START MADRID
Madrid, Spain, Spain
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Hospital Universitario HM Sanchinarro - CIOCC - START MADRID
Madrid, Spain, Spain
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Institut Claudius Regaud - PPDS
Toulouse, France
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Institut Curie - Hôpital de Paris
Paris, France
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Institut de Cancerologie de l'Ouest - Hôpital Saint Herblain - PPDS
Saint-Herblain, France
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Virginia Cancer Center
Fairfax, Virginia, 22031, United States
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Virginia Commonwealth University, Massey Comprehensive Cancer Center, McGlothlin Medical Education Center
Richmond, Virginia, 23298, United States
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