Botox injections tested for eczema insights in tiny pilot study

NCT ID NCT06928246

Recruiting now Knowledge-focused Sponsor: Daniel Kaplan Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study is testing whether Botox injections can change how skin cells behave in people with mild-to-moderate eczema. Eight adults will receive small doses of Botox into their eczema patches. Researchers will measure changes in eczema severity and analyze skin biopsies to understand nerve-immune interactions. The goal is to learn more about the disease, not to prove a new treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Botulinum toxin (Botox) injections
What this could lead to: If successful, this could point toward a new way to treat eczema by targeting nerve-immune system interactions.
What could go wrong: This is a very small, early-phase study with only 8 participants, so results may not apply to everyone. The main goal is to learn about skin biology, not to prove a treatment works.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atopic eczema Eczema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATOPIC DERMATITIS (AD)

Contacts and locations

Locations

UPMC Department of Dermatology
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
University of Pittsburgh Medical Center
NOT_YET_RECRUITING

Pittsburgh, Pennsylvania, 15213, United States

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