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Neck nerve block may dampen surgery stress — trial puts it to the test

NCT ID NCT07721818

Symptom relief Sponsor: University Hospital Dubrava Source: ClinicalTrials.gov ↗

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Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
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Not open to general applications. Only people the study team invites can take part.
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Paused for now. It may or may not start again.
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Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

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Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
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Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

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Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 23, 2026 · Last updated Jul 24, 2026 · Updated 1 time

Summary

This trial tests whether a targeted nerve block in the neck can lower the body's stress response during total thyroidectomy. Researchers will measure stress and inflammation markers in the saliva of 48 patients, half of whom receive the block plus standard anesthesia, while the other half receive anesthesia alone. The goal is to see if the block leads to a calmer surgical experience and faster recovery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ultrasound-guided bilateral intermediate cervical plexus block
What this could lead to
If it works, this could lead to a routine nerve block that reduces stress and speeds recovery after thyroid surgery.
What could go wrong
This is a small, early-phase trial with only 48 participants, so results may not apply broadly. The block carries rare risks like infection or nerve injury.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 48 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Apr 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * ASA I or ASA II * euthyroid status * signed informed consent Exclusion Criteria: * patients who refuse to sign the informed consent form * infection at the block injection site * hypersensitivity or contraindications to the medication used in the study * hypo/hyperthyroidism at the time of surgery * presence of substernal goiter * additional surgical interventions during the procedure * history of previous neck surgery or radiation * coagulopathy * uncontroled respiratory disease * diabetes mellitus * autoimune disease * chronic corticosteroid therapy * smokers * pregnant women

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cervical plexus block Saliva collection Surgical stress response Total thyroidectomy

How to take part

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  1. The official record

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    Open the record ↗

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