Two nerve blocks go head to head for mastectomy pain relief

NCT ID NCT07819786

Symptom relief Sponsor: Bursa City Hospital Source: ClinicalTrials.gov ↗

First seen Sep 15, 2026 · Last updated Sep 16, 2026 · Updated 1 time

Summary

Researchers compare two ultrasound-guided nerve block techniques to see which controls pain better after modified radical mastectomy, a common breast cancer operation. The study enrolls 86 adults scheduled for the surgery. One group receives an erector spinae plane block, the other a rhomboid intercostal and subserratus plane block, both with the numbing drug bupivacaine. The main measure is how much tramadol patients use in the first 24 hours after surgery, with pain scores and satisfaction as secondary checks.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: two ultrasound-guided nerve block techniques: erector spinae plane block and rhomboid intercostal and subserratus plane block, both using bupivacaine
What this could lead to: If one block proves better, it could give surgeons a clearer choice for controlling pain after breast cancer surgery and reducing reliance on opioid painkillers.
What could go wrong: This is a single-center comparison of two established techniques, so results may not apply everywhere. Nerve blocks carry small risks of bleeding, infection, or nerve irritation, and pain relief may vary between patients.

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Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

86 people

The number who actually took part.

Started

Jan 2026

Finished

Sep 2026

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Participants will be eligible for inclusion if they meet all of the following criteria: * Age between 18 and 80 years. * American Society of Anesthesiologists (ASA) physical status classification I-III. * Scheduled for elective modified radical mastectomy. * Willingness to participate in the study and ability to provide written informed consent. Exclusion Criteria: Participants will be excluded if they meet any of the following criteria: * Refusal to participate in the study or inability to provide informed consent. * Known or suspected allergy to local anesthetic agents. * Coagulopathy or a contraindication to regional anesthesia. * Requirement for uninterrupted anticoagulant therapy. * Infection at the site of block injection. * Any other condition considered by the investigators to make participation in the study inappropriate or unsafe.

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Conditions

The condition(s) this trial relates to.

breast cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Erector spinae block Postoperative analgesia Radical mastectomy Rhomboid intercostal sub-serratus plane block

Two nerve blocks go head to head for mastectomy pain relief

What the study statuses mean