Switching chemo Mid-Treatment shows promise for tough pancreatic cancers

NCT ID NCT04539808

First seen Nov 15, 2025 · Last updated May 06, 2026 · Updated 23 times

Summary

This study tests whether switching from one chemotherapy combination to another before surgery can help people with pancreatic cancer that can be removed or has spread nearby. About 42 adults with specific stages of pancreatic cancer will receive either FOLFIRINOX or gemcitabine/nab-paclitaxel, then switch to the other if needed, plus the drug losartan. The goal is to see if this approach leads to more successful surgeries and longer survival.

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Contacts and locations

Locations

  • OHSU Knight Cancer Institute

    Portland, Oregon, 97239, United States

Conditions

Explore the condition pages connected to this study.