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Could skipping hormone pills lower blood pressure risks in IVF?

NCT ID NCT04310683

Disease control Sponsor: Women's Hospital School Of Medicine Zhejiang University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled This study
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 24, 2026 · Last updated Aug 25, 2026 · Updated 1 time

Summary

This trial compares two methods of preparing the uterus for a frozen embryo transfer: a natural cycle without oral contraceptives versus a hormone-replaced cycle that uses oral contraceptives. The goal is to see if the natural approach is just as effective at achieving a live birth while potentially reducing the risk of pregnancy-related high blood pressure and preeclampsia. Women aged 20 to 45 scheduled for frozen embryo transfer may participate, excluding those with pre-existing hypertension, donated eggs or sperm, recurrent miscarriage, or ovulatory dysfunction.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
natural cycle for endometrium preparation (no oral contraceptives) versus hormone replaced cycle (with oral contraceptives)
What this could lead to
If natural cycles prove as effective as hormone-replaced cycles, they could reduce the risk of pregnancy-related high blood pressure and preeclampsia in women undergoing frozen embryo transfer.
What could go wrong
This is a single-center trial, and results may not apply broadly. The non-inferiority design means it aims to show natural cycles are not worse, but differences in live birth rates or other outcomes could still emerge.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Started

Dec 2020

Finished

Dec 2020

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 45 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. 20 to 45 years old women; 2. Scheduled to undergo frozen-thawed embryo transfer. 3. Agreeing with the informed consent. Exclusion Criteria: 1. Hypertention disease before embryo transfer; 2. Oocyte or sperm donated cycles 3. Recurrent miscarriage (at least two miscarriage history) 4. Ovulatory dysfunction

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Conditions

The condition(s) this trial relates to.

ventricular fibrillation, paroxysmal familial, type 1

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IVF

More trials for these conditions

Other studies related to the condition(s) this trial covers.