Small study tests drug for rare, Life-Threatening skin condition

NCT ID NCT02987257

Completed Disease control Sponsor: Vanderbilt University Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a drug called etanercept against a placebo for people with severe skin reactions (Stevens-Johnson syndrome and toxic epidermal necrolysis). Only 2 adults took part. The goal was to see if the drug speeds up skin healing and to learn more about the disease.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: etanercept
What this could lead to: If it works, this could point toward a better treatment for severe skin reactions like Stevens-Johnson syndrome.
What could go wrong: This trial was very small (only 2 participants) and completed, so results may not apply widely. Etanercept can increase infection risk.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Drug-Related Side Effects and Adverse Reactions Stevens-Johnson syndrome toxic epidermal necrolysis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

STEVENS-JOHNSON SYNDROME TOXIC EPIDERMAL NECROLYSES

Contacts and locations

Locations

Emory University at Grady Memorial Hospital

Atlanta, Georgia, 30303, United States
Johns Hopkins Bayview Medical Center

Baltimore, Maryland, 21224, United States
Loyola University Medical Center

Maywood, Illinois, 60153, United States
MedStar Washington Hospital Center

Washington D.C., District of Columbia, 20010, United States
University of California, Davis Medical Center

Sacramento, California, 95817, United States
University of Florida Health Burn Center

Gainesville, Florida, 32610, United States
University of Miami, Ryder Trauma Center

Miami, Florida, 33136, United States
University of Tennessee Health Sciences Center

Memphis, Tennessee, 38103, United States
University of Texas Medical Branch

Galveston, Texas, 77555, United States
University of Texas Southwestern Medical Center

Dallas, Texas, 75390, United States
University of Washington, Harborview Medical Center

Seattle, Washington, 98104, United States
Valleywise Health Medical Center

Phoenix, Arizona, 85008, United States
Vanderblt University Medical Center

Nashville, Tennessee, 37232, United States
Wayne State University

Detroit, Michigan, 48201, United States

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