Timing is everything: new study seeks to ease pain and protect hearts in elderly knee surgery

NCT ID NCT07271849

First seen Jan 04, 2026 · Last updated May 15, 2026 · Updated 22 times

Summary

This study looks at whether giving the painkiller nalbuphine at different times during knee replacement surgery can better control pain and keep the heart stable in patients aged 65 and older. About 162 participants will receive the same total dose of nalbuphine, but at different points before, during, or after surgery. The goal is to find the safest and most effective timing to reduce pain and avoid complications like blood pressure swings.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for POSTOPERATIVE PAIN, ACUTE are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Qianfoshan Hospital, The First Hospital affiliated of Shandong First Medical University,

    RECRUITING

    Jinan, Shandong, 250000, China

    Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

Explore the condition pages connected to this study.