New combo therapy targets Hard-to-Treat breast cancer
NCT ID NCT04837209
First seen Nov 01, 2025 · Last updated May 02, 2026 · Updated 28 times
Summary
This study tests whether combining two drugs (niraparib and dostarlimab) with radiation therapy is safe and effective for people with metastatic triple-negative breast cancer that has not responded to immunotherapy or is PD-L1 negative. The trial enrolls 32 adults with advanced disease. The goal is to see if this combination can shrink tumors and control the cancer.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Duke University Medical Center
Durham, North Carolina, 27710, United States
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Massachusetts General Hospital Cancer Center
Boston, Massachusetts, 02114, United States
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Sibley Memorial Hospital
Washington D.C., District of Columbia, 20016, United States
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University of Pennsylvania Abramson Cancer Center
Philadelphia, Pennsylvania, 19104, United States
Conditions
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