Antioxidant pill could slow 'Tunnel Vision' in inherited eye disease
NCT ID NCT05537220
Summary
This large, late-stage trial is testing whether a common antioxidant pill called N-acetylcysteine (NAC) can slow the progression of retinitis pigmentosa, an inherited eye disease that causes gradual vision loss. About 485 adults with the condition will take either NAC or a placebo pill daily for several years to see if it helps preserve their remaining central vision. The goal is to control the disease by protecting the eye's light-sensitive cells from damage, potentially delaying the onset of severe tunnel vision.
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Contacts and locations
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Locations
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Emory University, Emory Eye Center
Atlanta, Georgia, 30322, United States
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Harvard University, Mass. Eye and Ear
Boston, Massachusetts, 02114, United States
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Mayo Clinic, Department of Ophthalmology
Rochester, Minnesota, 55905, United States
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McGill University, The Research Institute of the McGill University Health Center
Montreal, Quebec, H4A 3J1, Canada
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Medical College of Wisconsin, The Eye Institute
Milwaukee, Wisconsin, 53226, United States
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Medical University of Graz, Department of Ophthalmology
Graz, Styria, 8036, Austria
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Northwestern University
Evanston, Illinois, 60208, United States
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Radboud University, Radboud University Medical Centre
Nijmegen, Gelderland, 6500 HB, Netherlands
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Retina Foundation of the Southwest
Dallas, Texas, 75231, United States
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Scheie Eye Institute
Philadelphia, Pennsylvania, 19104, United States
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Stanford University, Byers Eye Institute
Stanford, California, 94303, United States
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University College London, Moorfields Eye Hospital
London, England, United Kingdom
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University Of Illinois At Chicago
Chicago, Illinois, 60612, United States
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University of Amsterdam, Amsterdam Medical Center
Amsterdam, Northern Holland, 1105 AZ, Netherlands
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University of California - Davis, Department of Ophthalmology & Vision Science
Davis, California, 95817, United States
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University of California - San Francisco, Department of Ophthalmology
San Francisco, California, 94158, United States
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University of Florida - Jacksonville, UF Health Jacksonville
Jacksonville, Florida, 32209, United States
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University of Iowa, Carver College of Medicine
Iowa City, Iowa, 52242, United States
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University of Miami, Bascom Palmer Eye Institute
Miami, Florida, 33136, United States
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University of Michigan, Kellogg Eye Center
Ann Arbor, Michigan, 48105, United States
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University of Minnesota, Department of Ophthalmology and Visual Neurosciences
Minneapolis, Minnesota, 55455, United States
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University of Oklahoma, Dean McGee Eye Institute
Oklahoma City, Oklahoma, 73104, United States
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University of Southern California, Keck School of Medicine
Los Angeles, California, 90089, United States
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University of Tübingen, Department für Augenheilkunde
Tübingen, Baden-Wurttemberg, 72076, Germany
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University of Utah, Moran Eye Center
Salt Lake City, Utah, 84132, United States
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University of Washington, Department of Ophthalmology
Seattle, Washington, 98109, United States
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University of Wisconsin - Madison, McPherson Eye Research Institute
Madison, Wisconsin, 53705, United States
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Universitätsspital Basel, Eye Clinic
Basel, CH-4031, Switzerland
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Vanderbilt University, Vanderbilt Eye Institute
Nashville, Tennessee, 37211, United States
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Vitreo Retinal Associates
Gainesville, Florida, 32607, United States
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Wilmer Eye Institute- Johns Hopkins University
Baltimore, Maryland, 21287, United States
Conditions
Explore the condition pages connected to this study.