Could 3 chemo rounds be enough? new trial aims to cut treatment burden

NCT ID NCT05460000

Recruiting now Disease control Sponsor: North Eastern German Society of Gynaecological Oncology Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 28, 2026 · Updated 2 times

Summary

This study tests whether women with advanced ovarian cancer who have had all visible tumor removed can safely receive only 3 cycles of chemotherapy instead of the standard 6, followed by a maintenance drug called niraparib. The goal is to see if the shorter chemo is just as effective at preventing cancer from coming back, while reducing side effects. About 640 participants will be randomly assigned to either 3 or 6 cycles of chemo, both followed by niraparib.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: niraparib (a PARP inhibitor maintenance drug) and chemotherapy (carboplatin + paclitaxel)
What this could lead to: If successful, this could allow some ovarian cancer patients to have fewer chemotherapy cycles without compromising cancer control, reducing side effects.
What could go wrong: This is a Phase 2 trial, so results are preliminary. The shorter chemo might not be as effective, and niraparib has its own side effects like fatigue and nausea.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

clear cell adenocarcinoma fallopian tube cancer fallopian tube neoplasm ovarian cancer ovarian carcinoma ovarian clear cell cancer primary peritoneal carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CLEAR CELL CARCINOMA FALLOPIAN TUBE CANCER OVARIAN CANCER PRIMARY PERITONEAL CARCINOMA

Contacts and locations

Locations

AO Ordine Mauriziano
RECRUITING

Torino, Italy
AOU Cagliari
NOT_YET_RECRUITING

Monserrato, Italy
AOU Città della Salute e della Scienza di Torino - Ospedale Sant'Anna
RECRUITING

Torino, Italy
ASST Lecco - Ospedale A. Manzoni
ACTIVE_NOT_RECRUITING

Lecco, Italy
ASST Spedali Civili di Brescia
RECRUITING

Brescia, Italy
Azienda Ospedaliera Universitaria Pisana
ACTIVE_NOT_RECRUITING

Pisa, Italy
Azienda USL IRCCS Di Reggio Emilia
ACTIVE_NOT_RECRUITING

Reggio Emilia, Italy
CIOCC Clara Campal
RECRUITING

Madrid, Spain
Charité - Universitätsmedizin Berlin, Campus Virchow Klinikum
RECRUITING

Berlin, 13353, Germany
Christliches Klinikum Unna Mitte
RECRUITING

Unna, 59423, Germany
Cliniques Universitaires St. Luc
ACTIVE_NOT_RECRUITING

Brussels, Belgium
DRK-Kliniken Berlin-Köpenick
RECRUITING

Berlin, 12559, Germany
Diakonie Klinikum Schwäbisch Hall
RECRUITING

Schwäbisch Hall, Germany
Florence-Nightingale-Krankenhaus Düsseldorf-Kaiserswerth
ACTIVE_NOT_RECRUITING

Düsseldorf, Germany
General University Hospital in Prague
RECRUITING

Prague, Czechia
H. Althaia Manresa
ACTIVE_NOT_RECRUITING

Manresa, Spain
H.U. Virgen de la Macarena
RECRUITING

Seville, Spain
Helios Dr. Horst Schmidt Kliniken Wiesbaden
RECRUITING

Wiesbaden, 65199, Germany
Hospital General Universitario Dr. Balmis
RECRUITING

Alicante, Spain
Hospital General Universitario de Valencia
RECRUITING

Valencia, Spain
Hospital La Fe
ACTIVE_NOT_RECRUITING

Valencia, Spain
Hospital Universitario Lucus Augusti
ACTIVE_NOT_RECRUITING

Lugo, Spain
Hospital Universitario Sant Joan de Reus
RECRUITING

Tarragona, Spain
Hospital Universitario Virgen del Rocío
RECRUITING

Seville, Spain
Hospital Virgen de las Nieves
RECRUITING

Granada, Spain
IRCCS Istituto nazionale dei Tumori
RECRUITING

Milan, Italy
Istituto Oncologico Veneto (IOV)
RECRUITING

Padova, Italy
Jessa ziekenhuis
RECRUITING

Hasselt, Belgium
Klinikum Dortmund - Klinikum der Universität Witten Herdecke
ACTIVE_NOT_RECRUITING

Dortmund, Germany
Klinikum Dritter Orden
NOT_YET_RECRUITING

München, Germany
Klinikum Lippe
RECRUITING

Detmold, Germany
Klinikum Mittelbaden Baden-Baden Bühl
NOT_YET_RECRUITING

Baden-Baden, Germany
Policlinico St. Orsola Malpighi
RECRUITING

Bologna, Italy
SLK-Kliniken Heilbronn
NOT_YET_RECRUITING

Heilbronn, Germany
UZ Gent
ACTIVE_NOT_RECRUITING

Ghent, Belgium
UZ Leuven
ACTIVE_NOT_RECRUITING

Leuven, Belgium
Uniklinikum Bonn
RECRUITING

Bonn, Germany
University Hospital Bulovka
ACTIVE_NOT_RECRUITING

Prague, Czechia
University Hospital Ostrava
RECRUITING

Ostrava, Czechia
Universitätsklinik Göttingen
ACTIVE_NOT_RECRUITING

Göttingen, Germany
Universitätsklinik Innsbruck
RECRUITING

Innsbruck, 6020, Austria
Universitätsklinik der Johannes-Gutenberg Universität Mainz
ACTIVE_NOT_RECRUITING

Mainz, 55131, Germany
Universitätsklinikum Aachen
RECRUITING

Aachen, 52074, Germany
Universitätsklinikum Carl Gustav Carus
RECRUITING

Dresden, 01307, Germany
Universitätsklinikum Freiburg
ACTIVE_NOT_RECRUITING

Freiburg im Breisgau, Germany
Universitätsklinikum Hamburg-Eppendorf
ACTIVE_NOT_RECRUITING

Hamburg, Germany
Universitätsklinikum Köln
NOT_YET_RECRUITING

Cologne, Germany
Universitätsklinikum Leipzig
RECRUITING

Leipzig, Germany
Universitätsklinikum Schleswig-Holstein Campus Kiel
RECRUITING

Kiel, Germany
ZAHO Bonn Onkologische Praxis
ACTIVE_NOT_RECRUITING

Bonn, 53115, Germany

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