New hope for kidney disease: drug targets genetic root cause

NCT ID NCT06830629

Recruiting now Disease control Sponsor: Maze Therapeutics Source: ClinicalTrials.gov ↗

First seen Sep 30, 2025 · Last updated May 17, 2026 · Updated 27 times

Summary

This study tests an experimental drug called MZE829 in 56 adults with chronic kidney disease caused by a specific genetic risk (APOL1). The goal is to see if the drug can reduce protein leakage into urine (a sign of kidney damage) and is safe. Participants must have the high-risk APOL1 gene type and persistent protein in their urine.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

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Decatur, Alabama, 35601, United States
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Huntsville, Alabama, 35805, United States
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Montgomery, Alabama, 36106, United States
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Montgomery, Alabama, 36117, United States
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Granada Hills, California, 91344, United States
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Bloomfield, Connecticut, 06112, United States
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Atlantis, Florida, 33462, United States
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Brandon, Florida, 33511, United States
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Brooksville, Florida, 34613, United States
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Hollywood, Florida, 33024, United States
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Melbourne, Florida, 32901, United States
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Miami Lakes, Florida, 33014, United States
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Orlando, Florida, 32822, United States
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Atlanta, Georgia, 30309, United States
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College Park, Georgia, 30349, United States
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Cordele, Georgia, 31015, United States
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Lithia Springs, Georgia, 30122, United States
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Macon, Georgia, 31210, United States
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Riverdale, Georgia, 30274, United States
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Riverdale, Georgia, 30296, United States
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Savannah, Georgia, 31406, United States
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Snellville, Georgia, 30078, United States
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Chicago, Illinois, 60616, United States
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Chicago, Illinois, 60643, United States
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Kansas City, Kansas, 66112, United States
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Bowling Green, Kentucky, 42101, United States
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Louisville, Kentucky, 40205, United States
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Arnold, Maryland, 21012, United States
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Lutherville, Maryland, 21093, United States
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Oxon Hill, Maryland, 20745, United States
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Dearborn, Michigan, 48126, United States
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Flint, Michigan, 48503, United States
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Pontiac, Michigan, 48341, United States
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Saint Joseph, Michigan, 49085, United States
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Shelby, Michigan, 48092, United States
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Minneapolis, Minnesota, 55404, United States
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Tupelo, Mississippi, 38801, United States
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City of Saint Peters, Missouri, 63376, United States
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St Louis, Missouri, 63103, United States
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Las Vegas, Nevada, 89107, United States
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Buffalo, New York, 14203, United States
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Laurelton, New York, 11413, United States
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Maspeth, New York, 11378, United States
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New York, New York, 10021, United States
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Newburgh, New York, 12550, United States
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Durham, North Carolina, 27708, United States
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Fayetteville, North Carolina, 28304, United States
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Greensboro, North Carolina, 27405, United States
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Shelby, North Carolina, 28150, United States
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Cincinnati, Ohio, 45267, United States
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Cleveland, Ohio, 44106, United States
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Cleveland, Ohio, 44195, United States
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Columbus, Ohio, 43215, United States
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Ardmore, Oklahoma, 73401, United States
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Philadelphia, Pennsylvania, 19104, United States
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Philadelphia, Pennsylvania, 19107, United States
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Upland, Pennsylvania, 19013, United States
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Columbia, South Carolina, 29203, United States
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Spartanburg, South Carolina, 29302, United States
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Spartanburg, South Carolina, 29306, United States
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Chattanooga, Tennessee, 37404, United States
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Dallas, Texas, 75230, United States
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Dallas, Texas, 75246, United States
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Greenville, Texas, 75402, United States
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Houston, Texas, 77030, United States
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Houston, Texas, 77054, United States
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Houston, Texas, 77099, United States
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McKinney, Texas, 75069, United States
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San Antonio, Texas, 78251, United States
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Shenandoah, Texas, 77384, United States
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Sherman, Texas, 75092, United States
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Norfolk, Virginia, 23504, United States
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Créteil, 94010, France
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Lyon, 69347, France
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Paris, 75015, France
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Paris, 75020, France
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Saint-Ouen, 93400, France
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Leicester, LE5 4PW, United Kingdom
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London, NW3 2QG, United Kingdom
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London, SE19RT, United Kingdom
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London, SE59RS, United Kingdom

Conditions

Explore the condition pages connected to this study.

PROTEINURIC KIDNEY DISEASE