New drug combo targets tough blood cancer symptoms

NCT ID NCT03222609

Completed Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

Summary

This study tested whether adding a new drug called navitoclax to an existing treatment (ruxolitinib) could better control myelofibrosis, a serious bone marrow cancer. It involved 191 adults whose disease was not well-controlled on current treatments. Researchers measured if the treatments could shrink an enlarged spleen, reduce symptoms like fatigue and pain, and improve anemia.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Show contact details

Locations

AOU Policlinico G. Rodolico - San Marco /ID# 214549

Catania, 95123, Italy
ASST Papa Giovanni XXIII /ID# 214900

Bergamo, 24127, Italy
ASST Sette Laghi - Ospedale Di Circolo E Fondazione Macchi Varese /ID# 214551

Varese, 21100, Italy
ASST degli Spedali Civili di Brescia /ID# 230420

Brescia, 25123, Italy
Aneurin Bevan University Health Board /ID# 230332

Newport, NP18 3XQ, United Kingdom
Aomori Prefectural Central Hospital /ID# 221773

Aomori, Aomori, 030-8553, Japan
Ascension Providence Southfield Cancer Center /ID# 223876

Southfield, Michigan, 48075-3707, United States
Assuta Ashdod Medical Center /ID# 230396

Ashdod, Southern District, 7747629, Israel
Azienda Ospedaliero Universitaria Careggi /ID# 214555

Florence, Firenze, 50134, Italy
Baptist MD Anderson Cancer Center - Jacksonville /ID# 222548

Jacksonville, Florida, 32207-8432, United States
Barwon Health /ID# 222430

Geelong, Victoria, 3220, Australia
Belfast Health and Social Care Trust /ID# 216991

Belfast, BT9 7AB, United Kingdom
Bend Memorial Clinic /ID# 224184

Bend, Oregon, 97701, United States
CLINICA UNIVERSIDAD DE NAVARRA-Madrid /ID# 230719

Madrid, 28027, Spain
City of Hope /ID# 221395

Duarte, California, 91010, United States
Clinical Hospital Dubrava /ID# 230504

Zagreb, City of Zagreb, 10000, Croatia
Colorado Blood Cancer Institute /ID# 224250

Denver, Colorado, 80218, United States
Dana-Farber Cancer Institute /ID# 162675

Boston, Massachusetts, 02215, United States
Duplicate_American Oncology Partners of Maryland, PA /ID# 231299

Bethesda, Maryland, 20817, United States
Duplicate_CLINICA UNIVERSIDAD DE NAVARRA-Pamplona /ID# 230718

Pamplona, Navarre, 31008, Spain
Duplicate_Del-pesti Centrumkorhaz Orszagos Hematologiai es Infektologiai Intezet /ID# 230306

Budapest, 1097, Hungary
Duplicate_Dokkyo Medical University Saitama Medical Center /ID# 222332

Koshigaya-shi, Saitama, 343-8555, Japan
Duplicate_Medical University of South Carolina /ID# 222597

Charleston, South Carolina, 29425, United States
Duplicate_University General Hospital Attikon /ID# 230395

Athens, Attica, 12462, Greece
Duplicate_University of Alberta Hospital - Division of Hematology /ID# 217698

Edmonton, Alberta, T6G 2B7, Canada
Fiona Stanley Hospital /ID# 216809

Murdoch, Western Australia, 6150, Australia
Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Università Cattolica /ID# 214553

Rome, Roma, 00168, Italy
Fujita Health University Hospital /ID# 221539

Toyoake, Aichi-ken, 470-1192, Japan
Galilee Medical Center /ID# 230397

Nahariya, Northern District, 2210001, Israel
General Hospital of Athens Laiko /ID# 230394

Athens, Attica, 11527, Greece
Grande Ospedale Metropolitano Bianchi - Melacrino - Morelli P.O. Riuniti /ID# 230011

Reggio Calabria, 89125, Italy
Guys and St Thomas NHS Foundation Trust /ID# 164110

London, Greater London, SE1 9RT, United Kingdom
Hadassah Medical Center-Hebrew University /ID# 230310

Jerusalem, Jerusalem, 91120, Israel
Henry Ford Hospital /ID# 162682

Detroit, Michigan, 48202, United States
Hospital General Universitario Gregorio Maranon /ID# 214676

Madrid, 28007, Spain
Hospital Regional Universitario de Malaga /ID# 230858

Málaga, 29011, Spain
Hospital Universitario 12 de Octubre /ID# 214710

Madrid, 28041, Spain
Hospital Universitario Germans Trias i Pujol /ID# 214704

Badalona, Barcelona, 08916, Spain
Hospital Universitario Vall d'Hebron /ID# 222415

Barcelona, 08035, Spain
Hospital Universitario Virgen de la Victoria /ID# 214709

Málaga, 29010, Spain
Hospital del Centro Comprensivo de Cancer de la UPR /ID# 222544

San Juan, 00927, Puerto Rico
IRCCS AOU di Bologna - Policlinico Sant'Orsola-Malpighi /ID# 230012

Bologna, Emilia-Romagna, 40138, Italy
Indiana Blood & Marrow Transpl /ID# 165075

Indianapolis, Indiana, 46237, United States
Juntendo University Hospital /ID# 221484

Bunkyo-ku, Tokyo, 113-8431, Japan
Kansai Medical University Hospital /ID# 222690

Hirakata-shi, Osaka, 573-1191, Japan
Kaohsiung Chang Gung Memorial Hospital /ID# 230371

Kaohsiung City, Kaohsiung, 833, Taiwan
Kindai University Hospital /ID# 222689

Osakasayama-shi, Osaka, 589-8511, Japan
Klinicka bolnica Merkur /ID# 230599

Zagreb, City of Zagreb, 10000, Croatia
Klinicki Bolnicki Centar (KBC) Split /ID# 230601

Split, Split-Dalmatia County, 21000, Croatia
Klinicki bolnicki centar Zagreb /ID# 230602

Zagreb, City of Zagreb, 10000, Croatia
Kyushu University Hospital /ID# 222691

Fukuoka, Fukuoka, 812-8582, Japan
Long Beach Memorial Medical Ct /ID# 230148

Long Beach, California, 90806-1701, United States
MD Anderson Cancer Center at Texas Medical Center /ID# 162683

Houston, Texas, 77030-4000, United States
Mayo Clinic /ID# 164201

Jacksonville, Florida, 32224, United States
McGill University Health Center Research Institute /ID# 223976

Montreal, Quebec, H4A 3J1, Canada
Mid Illinois Hematology & Oncology Associates, Ltd /ID# 230536

Normal, Illinois, 61761, United States
MidAmerica Division, Inc. /ID# 222058

Kansas City, Missouri, 64132, United States
Moffitt Cancer Center /ID# 164082

Tampa, Florida, 33612-9416, United States
Moores Cancer Center at UC San Diego /ID# 164084

La Jolla, California, 92093, United States
National Cheng Kung University Hospital /ID# 230372

Tainan, 704, Taiwan
Nippon Medical School Hospital /ID# 222692

Bunkyo-ku, Tokyo, 113-8602, Japan
Oncology Consultants /ID# 230930

Houston, Texas, 77030-3306, United States
Oxford University Hospitals NHS Foundation Trust /ID# 214503

Oxford, Oxfordshire, OX3 9DU, United Kingdom
Peter MacCallum Cancer Ctr /ID# 218352

Melbourne, Victoria, 3000, Australia
Prairie Lakes Healthcare System /ID# 224358

Watertown, South Dakota, 57201, United States
Samsung Medical Center /ID# 230381

Seoul, Seoul Teugbyeolsi, 06351, South Korea
Sapporo Hokuyu Hospital /ID# 222693

Sapporo, Hokkaido, 003-0006, Japan
Semmelweis Egyetem /ID# 230518

Budapest, 1085, Hungary
Seoul National University Hospital /ID# 230380

Seoul, Seoul Teugbyeolsi, 03080, South Korea
Szabolcs-Szatmar-Bereg Varmegyei Oktatokorhaz /ID# 230585

Nyíregyháza, Szabolcs-Szatmár-Bereg, 4400, Hungary
TOI Clinical Research /ID# 222546

Cerritos, California, 90703-2679, United States
Tel Aviv Sourasky Medical Center /ID# 230311

Tel Aviv, Tel Aviv, 6423906, Israel
Tennessee Oncology-Nashville Centennial /ID# 221410

Nashville, Tennessee, 37203-1632, United States
Texas Oncology - West Texas /ID# 224784

Abilene, Texas, 79606, United States
Texas Oncology- Baylor Charles A. Sammons Cancer Center /ID# 225159

Dallas, Texas, 75246-2003, United States
The Alfred Hospital /ID# 215545

Melbourne, Victoria, 3004, Australia
The Christie Hospital /ID# 164111

Manchester, M20 4BX, United Kingdom
The Kinghorn Cancer Centre /ID# 214657

Darlinghurst, New South Wales, 2010, Australia
The Ohio State University /ID# 217402

Columbus, Ohio, 43210-1280, United States
UAB Comprehensive Cancer Cente /ID# 165464

Birmingham, Alabama, 35217, United States
University Health Network_Princess Margaret Cancer Centre /ID# 214483

Toronto, Ontario, M5G 2M9, Canada
University of Chicago Medicine /ID# 164115

Chicago, Illinois, 60637-1426, United States
University of Massachusetts - Worcester /ID# 222547

Worcester, Massachusetts, 01655, United States
University of Southern California /ID# 164095

Los Angeles, California, 90033, United States
University of Texas Health San Antonio MD Anderson Cancer Center /ID# 164094

San Antonio, Texas, 78229, United States
University of Utah /ID# 164116

Salt Lake City, Utah, 84112-5500, United States
University of Yamanashi Hospital /ID# 221700

Chuo-shi, Yamanashi, 409-3821, Japan
Utah Cancer Specialists Salt Lake Clinic /ID# 222806

Salt Lake City, Utah, 84106, United States
VA Caribbean Healthcare System /ID# 222416

San Juan, 00921-3201, Puerto Rico
Weill Cornell Medical College /ID# 162679

New York, New York, 10065, United States
West Penn Hospital /ID# 222618

Pittsburgh, Pennsylvania, 15224-1722, United States

Conditions

Explore the condition pages connected to this study.

MYELOFIBROSIS，MF