New ventilator method may save fragile preemies from breathing tubes
NCT ID NCT06849596
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares two ways to help extremely premature babies (born at 25-28 weeks) breathe right after birth. One method uses a standard manual T-piece device; the other uses a ventilator to deliver gentle puffs of air through a nasal mask. The goal is to see if the ventilator approach reduces the chance of death or serious complications like brain injury or chronic lung disease. About 780 babies will take part across multiple hospitals.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Ventilator-derived positive pressure ventilation (V-PPV) via nasal mask
What this could lead to
If it works, this could lead to a better way to help extremely premature babies breathe right after birth, reducing the need for a breathing tube and lowering the risk of death or brain injury.
What could go wrong
This is a relatively early-stage trial, and the ventilator method may not prove better than the standard T-piece. The babies are extremely fragile, so any breathing support carries risks.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Locations
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BC Children's and Women's Hospital
NOT_YET_RECRUITINGVancouver, British Columbia, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHU Sainte Justine
RECRUITINGMontreal, Quebec, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Cedars-Sinai Guerin Children's
RECRUITINGLos Angeles, California, 90505, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Children's Hospital at London Health Sciences Centre
NOT_YET_RECRUITINGLondon, Ontario, Canada
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Foothills Medical Centre
RECRUITINGCalgary, Alberta, Canada
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McMaster Children's Hospital
RECRUITINGHamilton, Ontario, Canada
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Montreal Children's Hospital
RECRUITINGMontral, Quebec, Canada
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Mount Sinai Hospital
RECRUITINGToronto, Ontario, M5G 1X5, Canada
Contact
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Rigshospitalet Coppenhagen
NOT_YET_RECRUITINGCopenhagen, Denmark
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Royal Alexandra Hospital
RECRUITINGEdmonton, Alberta, Canada
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