New ventilator method may save fragile preemies from breathing tubes

NCT ID NCT06849596

Recruiting now Disease control Sponsor: Michelle Baczynski Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two ways to help extremely premature babies (born at 25-28 weeks) breathe right after birth. One method uses a standard manual T-piece device; the other uses a ventilator to deliver gentle puffs of air through a nasal mask. The goal is to see if the ventilator approach reduces the chance of death or serious complications like brain injury or chronic lung disease. About 780 babies will take part across multiple hospitals.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Ventilator-derived positive pressure ventilation (V-PPV) via nasal mask
What this could lead to: If it works, this could lead to a better way to help extremely premature babies breathe right after birth, reducing the need for a breathing tube and lowering the risk of death or brain injury.
What could go wrong: This is a relatively early-stage trial, and the ventilator method may not prove better than the standard T-piece. The babies are extremely fragile, so any breathing support carries risks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

apnea of prematurity Lung Injury Premature Birth Respiratory Aspiration

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

APNEA NEONATAL NEONATAL RESUSCITATION

Contacts and locations

Locations

BC Children's and Women's Hospital
NOT_YET_RECRUITING

Vancouver, British Columbia, Canada
CHU Sainte Justine
RECRUITING

Montreal, Quebec, Canada
Cedars-Sinai Guerin Children's
RECRUITING

Los Angeles, California, 90505, United States
Children's Hospital at London Health Sciences Centre
NOT_YET_RECRUITING

London, Ontario, Canada
Foothills Medical Centre
RECRUITING

Calgary, Alberta, Canada
McMaster Children's Hospital
RECRUITING

Hamilton, Ontario, Canada
Montreal Children's Hospital
RECRUITING

Montral, Quebec, Canada
Mount Sinai Hospital
RECRUITING

Toronto, Ontario, M5G 1X5, Canada
Rigshospitalet Coppenhagen
NOT_YET_RECRUITING

Copenhagen, Denmark
Royal Alexandra Hospital
RECRUITING

Edmonton, Alberta, Canada

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