New hope for myeloma: phase 3 trial pits JNJ-79635322 against current drug

NCT ID NCT07518186

Recruiting now Disease control Sponsor: Janssen Research & Development, LLC Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 31, 2026 · Updated 4 times

Summary

This phase 3 study compares a new injectable drug, JNJ-79635322, to an existing one, teclistamab, in about 700 people with multiple myeloma that has returned after 1 to 3 prior treatments. The goal is to see which drug works better at shrinking tumors and delaying disease progression. Participants must have had prior therapy including an anti-CD38 antibody and lenalidomide.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: JNJ-79635322 (injection)
What this could lead to: If it works, this could offer a more effective treatment option for people with multiple myeloma that has returned after initial therapies.
What could go wrong: This is an early-stage comparison; the new drug may not prove better than the existing one, and side effects are possible. Results are not guaranteed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

plasma cell myeloma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTIPLE MYELOMA

Contacts and locations

Locations

Alabama Oncology
RECRUITING

Birmingham, Alabama, 35211, United States
Alexandra General Hospital of Athens
RECRUITING

Athens, 11528, Greece
Ankara University Medical Faculty
RECRUITING

Ankara, 06620, Turkey (Türkiye)
Asan Medical Center
RECRUITING

Seoul, 05505, South Korea
Asklepios Klinik Altona
RECRUITING

Hamburg, 22763, Germany
Astera Cancer Care
RECRUITING

East Brunswick, New Jersey, 08816, United States
Azienda Ospedaliero Universitaria Maggiore della Carita di Novara
RECRUITING

Novara, 28100, Italy
Beijing Chaoyang Hospital
RECRUITING

Chaoyang District, 100020, China
Beverly Hills Cancer Center Clinical Research Advisors LLC
RECRUITING

Beverly Hills, California, 90211, United States
Bhagwan Mahaveer Cancer Hospital & Research Centre
RECRUITING

Jaipur, 302017, India
Bon Secours Saint Francis Cancer Center
RECRUITING

Greenville, South Carolina, 29607, United States
CHRU de Tours
RECRUITING

Tours, 37000, France
CHU Nantes - Hotel Dieu
RECRUITING

Nantes, 44000, France
CHU Toulouse
RECRUITING

Toulouse, 31300, France
Carmel Medical Center
RECRUITING

Haifa, 3436212, Israel
Casa di Cura La Maddalena
RECRUITING

Palermo, 90146, Italy
Centrum Onkologii Ziemi Lubelskiej im sw Jana z Dukli
RECRUITING

Lublin, 20 090, Poland
China Medical University Hospital
RECRUITING

Taichung, 40447, Taiwan
Chonnam National University Hwasun Hospital
RECRUITING

Hwasun, 58128, South Korea
Christus St. Vincent Regional Cancer Center
RECRUITING

Santa Fe, New Mexico, 87505, United States
Clinica Univ. de Navarra
RECRUITING

Pamplona, 31008, Spain
Deenanath Mangeshkar Hospital and Research Centre
RECRUITING

Pune, 411004, India
Emory University
RECRUITING

Atlanta, Georgia, 30322, United States
Evangelismos S A
RECRUITING

Athens, 106 76, Greece
Franciscan Health
RECRUITING

Indianapolis, Indiana, 46237-8601, United States
Gabrail Cancer Center
RECRUITING

Canton, Ohio, 44718, United States
Gunma University Hospital
RECRUITING

Gunma, 371-0034, Japan
Highlands Oncology Group
RECRUITING

Springdale, Arkansas, 72762, United States
Hosp Reina Sofia
RECRUITING

Córdoba, 14004, Spain
Hosp. Clinic de Barcelona
RECRUITING

Barcelona, 08036, Spain
Hosp. San Pedro de Alcantara
RECRUITING

Cáceres, 10003, Spain
Hosp. Univ. 12 de Octubre
RECRUITING

Madrid, 28041, Spain
Hosp. Univ. Marques de Valdecilla
RECRUITING

Santander, 39008, Spain
Hosp. Virgen Del Rocio
RECRUITING

Seville, 41013, Spain
Hosp. de Jerez de La Frontera
RECRUITING

Jerez de la Frontera, 11407, Spain
Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences
RECRUITING

Tijian, 300020, China
Istanbul Florance Nightingale Hospital
RECRUITING

Istanbul, 34381, Turkey (Türkiye)
Izmir Tinaztepe University Galen Hospital
RECRUITING

Izmir, 35001, Turkey (Türkiye)
Joe Arrington Cancer Research Treatment Center
RECRUITING

Lubbock, Texas, 79410, United States
Kanagawa Cancer Center
RECRUITING

Yokohama, 241 8515, Japan
Karmanos Cancer Institute
RECRUITING

Detroit, Michigan, 48201, United States
LSU Health Feist Weiller Cancer Center
RECRUITING

Shreveport, Louisiana, 71103, United States
Laura & Isaac Perlmutter Cancer Center at NYU Langone Hospital - Long Island
RECRUITING

Mineola, New York, 11501, United States
Liv Hospital Ankara
RECRUITING

Ankara, 06680, Turkey (Türkiye)
MTZ Clinical Research Powered by Pratia
RECRUITING

Warsaw, 02-172, Poland
Matsuyama Red Cross Hospital
RECRUITING

Matsuyama, 790-8524, Japan
Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States
Mayo Clinic 1
RECRUITING

Phoenix, Arizona, 85054, United States
Mayo Clinic Jacksonville
RECRUITING

Jacksonville, Florida, 32224, United States
Medipol Mega University Hospital
RECRUITING

Istanbul, 34214, Turkey (Türkiye)
Memorial Antalya Hospital
RECRUITING

Antalya, 07025, Turkey (Türkiye)
Memorial Cancer Institute
RECRUITING

Pembroke Pines, Florida, 33026, United States
Mersin University Medical Faculty
RECRUITING

Mersin, 33110, Turkey (Türkiye)
NYU Langone Health Manhattan
RECRUITING

New York, New York, 10016, United States
National Cheng Kung University Hospital
RECRUITING

Tainan, 70403, Taiwan
National Hospital Organization Kyushu Medical Center
RECRUITING

Fukuoka, 810 8563, Japan
National Hospital Organization Okayama Medical Center
RECRUITING

Okayama, 701-1192, Japan
National Taiwan University Hospital
RECRUITING

Taipei, 100, Taiwan
Nebraska Cancer Specialists
RECRUITING

Omaha, Nebraska, 68130, United States
New York Cancer and Blood Specialists
RECRUITING

Shirley, New York, 11967, United States
New York Oncology Hematology
RECRUITING

Albany, New York, 12208, United States
Nil Ratan Sircar Medical College and Hospital
RECRUITING

Kolkata, 700014, India
Norton Cancer Institute
RECRUITING

Louisville, Kentucky, 40207, United States
Ondokuz Mayis University
RECRUITING

Samsun, 55420, Turkey (Türkiye)
Pratia Onkologia Katowice
RECRUITING

Katowice, 40 519, Poland
Rabin Medical Center
RECRUITING

Petah Tikva, 4941492, Israel
Rambam Med.Center - Hematology Institute
RECRUITING

Haifa, 3109601, Israel
Samson Assuta Ashdod University Hospital
RECRUITING

Ashdod, 7747629, Israel
Samsung Medical Center
RECRUITING

Seoul, 06351, South Korea
Sapporo City General Hospital
RECRUITING

Sapporo, 060-8604, Japan
Seoul National University Bundang Hospital
RECRUITING

Gyeonggi-do, 13620, South Korea
Sheba Medical Center
RECRUITING

Ramat Gan, 5266202, Israel
Specjalistyczny Szpital im dra Alfreda Sokolowskiego w Walbrzychu
RECRUITING

Wałbrzych, 58 309, Poland
St Vincent s Hospital Sydney
RECRUITING

Darlinghurst, 2010, Australia
Taichung Veterans General Hospital
RECRUITING

Taichung, 40705, Taiwan
Taipei Veterans General Hospital
RECRUITING

Taipei, 112, Taiwan
Tel Aviv Sourasky Medical Center
RECRUITING

Tel Aviv, 6423906, Israel
The Cancer Institute Hospital of JFCR
RECRUITING

Tokyo, 135-8550, Japan
The Catholic University of Korea Seoul St Marys Hospital
RECRUITING

Seoul, 06591, South Korea
The Christ Hospital
RECRUITING

Cincinnati, Ohio, 45069, United States
Universitaetsklinik Tuebingen
RECRUITING

Tübingen, 72076, Germany
Universitaetsklinikum Freiburg
RECRUITING

Freiburg im Breisgau, 79106, Germany
University General Hospital Attikon General Hospital Of West Attica H Agia Varvara
RECRUITING

Athens, 124 62, Greece
University General Hospital of Ioannina
RECRUITING

Ioannina, 455 00Q, Greece
University Hospital Kyoto Prefectural University of Medicine
RECRUITING

Kyoto, 602-8566, Japan
University Of Minnesota Medical Center
RECRUITING

Minneapolis, Minnesota, 55455, United States
Utah Cancer Specialists
RECRUITING

Salt Lake City, Utah, 84102, United States
Valkyrie Clinical Trials
RECRUITING

Los Angeles, California, 90067, United States

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