New hope for Tough-to-Treat myeloma: phase 3 trial launches

NCT ID NCT07258511

Recruiting now Disease control Sponsor: Janssen Research & Development, LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 5 times

Summary

This study tests a new drug, JNJ-79635322, against another antibody treatment in people with multiple myeloma that has come back or stopped responding after at least three prior treatments. About 400 participants will be randomly assigned to one of the two treatments. The goal is to see which one works better at shrinking tumors and delaying disease progression.

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Conditions

The condition(s) this trial relates to.

plasma cell myeloma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTIPLE MYELOMA

Contacts and locations

Locations

A.O.U. SS. Antonio e Biagio e Cesare Arrigo
RECRUITING

Alessandria, 15121, Italy
APHP
RECRUITING

Paris, 75012, France
Akershus Universitetssykehus
RECRUITING

Lorenskog, 1478, Norway
Alexandra General Hospital of Athens
RECRUITING

Athens, 11528, Greece
Arcispedale Santa Maria Nuova - IRCCS
RECRUITING

Reggio Emilia, 42123, Italy
Arthur J E Child Comprehensive Cancer Centre
RECRUITING

Calgary, Alberta, T2N 4N1, Canada
Assuta MC
RECRUITING

Tel Aviv, 69710, Israel
Baruch Padeh MC
RECRUITING

Ramat Poriya, 1520800, Israel
Baylor University Medical Center
RECRUITING

Dallas, Texas, 75246, United States
Bnai Zion Medical Center
RECRUITING

Haifa, 31048, Israel
Box Hill Hospital
RECRUITING

Box Hill, 3128, Australia
British Columbia Cancer Agency
RECRUITING

Vancouver, British Columbia, V5Z4E6, Canada
CHRU de Tours
RECRUITING

Tours, 37000, France
CHU Toulouse
RECRUITING

Toulouse, 31300, France
CHU de Bordeaux - Hospital Haut-Leveque
RECRUITING

Pessac, 33600, France
CIUSSS de l Est de l Ile de Montreal Installation Hopital Maisonneuve Rosemont
RECRUITING

Montreal, Quebec, H1T 2M4, Canada
Campus Bio Medico di Roma
RECRUITING

Roma, 00128, Italy
Cardiff and Vale UHB - University Hospital of Wales
RECRUITING

Cardiff, CF14 4XW, United Kingdom
Carmel Medical Center
RECRUITING

Haifa, 34362, Israel
Casa Sollievo Della Sofferenza IRCCS
RECRUITING

San Giovanni Rotondo, 71013, Italy
Chiba Cancer Center
RECRUITING

Chiba, 260 0801, Japan
City of Hope Chicago
RECRUITING

Zion, Illinois, 60099, United States
City of Hope Duarte
RECRUITING

Duarte, California, 91010, United States
City of Hope Orange County Lennar Foundation Cancer Center
RECRUITING

Irvine, California, 92618, United States
Colorado Blood Cancer Institute
RECRUITING

Denver, Colorado, 80218, United States
Durham VAMC
RECRUITING

Durham, North Carolina, 27705, United States
Emory University
RECRUITING

Atlanta, Georgia, 30322, United States
Erasmus MC
RECRUITING

Rotterdam, 3015, Netherlands
Evangelismos S A
RECRUITING

Athens, 106 76, Greece
Fiona Stanley Hospital
RECRUITING

Murdoch, 6150, Australia
First affiliated Hospital of Zhejiang University
RECRUITING

Hangzhou, 310003, China
Florida Cancer Specialists & Research Institute
RECRUITING

Fort Myers, Florida, 33901, United States
Fondazione IRCCS Ca Granda Ospedale Policlinico Di Milano
RECRUITING

Milan, 20122, Italy
Fondazione Policlinico Universitario A Gemelli IRCCS
RECRUITING

Roma, 00168, Italy
Geniko Nosokomeio Thessalonikis George Papanikolaou
RECRUITING

Thessaloniki, 570 10, Greece
Gold Coast University Hospital
RECRUITING

Southport, 4215, Australia
H. Vall D'Hebron
RECRUITING

Barcelona, 08035, Spain
Haga ziekenhuis
RECRUITING

The Hague, 2545 AA, Netherlands
Hopital Saint Louis APHP
RECRUITING

Paris, 75010, France
Hosp Clinico Univ de Salamanca
RECRUITING

Salamanca, 37007, Spain
Hosp. Clinic de Barcelona
RECRUITING

Barcelona, 08036, Spain
Hosp. Quiron Madrid Pozuelo
RECRUITING

Pozuelo de Alarcón, 28223, Spain
Hosp. Univ. 12 de Octubre
RECRUITING

Madrid, 28041, Spain
Hosp. Univ. Germans Trias I Pujol
RECRUITING

Badalona, 08916, Spain
Hosp. Univ. I Politecni La Fe
RECRUITING

Valencia, 46026, Spain
Hosp. Univ. Virgen de Las Nieves
RECRUITING

Granada, 18014, Spain
Hospices Civils de Lyon HCL
RECRUITING

Lyon, 69002, France
Hotel Dieu CHU de Nantes
RECRUITING

Nantes, 44000, France
Humanitas Hospital
RECRUITING

Rozzano, 20089, Italy
Huntsman Cancer Institute
RECRUITING

Salt Lake City, Utah, 84112, United States
Icahn School of Medicine at Mount Sinai
RECRUITING

New York, New York, 10029, United States
Japanese Red Cross Medical Center
RECRUITING

Shibuya City, 150-8935, Japan
Juravinski Cancer Centre
RECRUITING

Hamilton, Ontario, L8V5C2, Canada
Kameda Medical Center
RECRUITING

Kamogawa, 296-8602, Japan
Kanagawa Cancer Center
RECRUITING

Yokohama, 241 8515, Japan
Kent and Canterbury Hospital
RECRUITING

Canterbury, CT1 3NG, United Kingdom
Laura and Isaac Perlmutter Cancer Center NYU ACC
RECRUITING

New York, New York, 10016, United States
London Health Sciences Centre
RECRUITING

London, Ontario, N6A 5W9, Canada
Marien Hospital Dusseldorf
RECRUITING

Düsseldorf, 40479, Germany
Mater Misericordiae Ltd
RECRUITING

Brisbane, 4101, Australia
Mayo Clinic Jacksonville
RECRUITING

Jacksonville, Florida, 32224, United States
Mayo Clinic Phoenix
RECRUITING

Phoenix, Arizona, 85054, United States
Mayo Clinic Rochester
RECRUITING

Rochester, Minnesota, 55905, United States
Medical College Of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Mission Cancer Blood
RECRUITING

Waukee, Iowa, 50263, United States
Moffit Cancer center
RECRUITING

Tampa, Florida, 33612, United States
Monash Medical Centre
RECRUITING

Clayton, 3168, Australia
Mount Sinai Brooklyn
RECRUITING

Brooklyn, New York, 11234, United States
Mount Sinai Chelsea
RECRUITING

New York, New York, 10011, United States
NYU Winthrop
RECRUITING

Mineola, New York, 11501, United States
Nanjing Drum Tower Hospital
RECRUITING

Nanjing, 210008, China
Ninewells Hospital & Medical School
RECRUITING

Dundee, DD1 9SY, United Kingdom
Norton Cancer Institute
RECRUITING

Louisville, Kentucky, 40207, United States
Nottingham City Hospital
RECRUITING

Nottingham, NG5 1PB, United Kingdom
Oregon Health And Science University
RECRUITING

Portland, Oregon, 97239, United States
Oslo University Hospital HF Ulleval sykehus
RECRUITING

Oslo, 0450, Norway
Ospedale Santa Chiara AO Universitaria Pisana
RECRUITING

Pisa, 56126, Italy
Peking University People's Hospital
RECRUITING

Beijing, 100044, China
Queen Alexandra Hospital
RECRUITING

Portsmouth, PO6 3LY, United Kingdom
Queen Elizabeth II Health Sciences Centre
RECRUITING

Halifax, Nova Scotia, B3H 3A7, Canada
Radboud Umcn
RECRUITING

Nijmegen, 6525 GA, Netherlands
Rambam Medical Center
RECRUITING

Haifa, 3109601, Israel
Royal Marsden Hospital
RECRUITING

Sutton, SM2 5PT, United Kingdom
SCRI Oncology Partners
RECRUITING

Nashville, Tennessee, 37203, United States
Shaare Zedek MC
RECRUITING

Jerusalem, 9103102, Israel
Shanghai Fourth People s Hospital
RECRUITING

Shanghai, 200434, China
Sheba Medical Center
RECRUITING

Ramat Gan, 52621, Israel
Shonan Kamakura General Hospital
RECRUITING

Kamakura-shi, 247-8533, Japan
Sir Charles Gairdner Hospital
RECRUITING

Nedlands, 6009, Australia
Soroka Medical Center
RECRUITING

Beersheba, 8457108, Israel
Spedali Civili di Brescia
RECRUITING

Brescia, 25123, Italy
St Vincents Hospital Melbourne
RECRUITING

Fitzroy, 3065, Australia
St. Antonius Ziekenhuis Nieuwegein
RECRUITING

Nieuwegein, 3435 CM, Netherlands
St. David's South Austin Medical Center
RECRUITING

Austin, Texas, 78704, United States
St. Olavs Hospital
RECRUITING

Trondheim, 7030, Norway
Stavanger University Hospital Ullandhaug
RECRUITING

Stavanger, 4021, Norway
Sun Yat Sen University Cancer Center
RECRUITING

Guangzhou, 510060, China
Texas Transplant Institute
RECRUITING

San Antonio, Texas, 78229, United States
The Alfred Hospital
RECRUITING

Melbourne, 3004, Australia
The First Affiliated Hospital of Guangxi Medical University
RECRUITING

Nanning, 530021, China
The Jikei University Hospital
RECRUITING

Minato, 105-8471, Japan
Theageneio Cancer Hospital
RECRUITING

Thessaloniki, 546 39, Greece
Thomas Jefferson University Hospital
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital
RECRUITING

Bunkyō City, 113 8677, Japan
U.O. Ematologia Ospedale San Bortolo
RECRUITING

Vicenza, 36100, Italy
UAMS
RECRUITING

Little Rock, Arkansas, 72205, United States
USC Norris Comprehensive Cancer Center
RECRUITING

Los Angeles, California, 90033, United States
UT Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States
Universitaetsklinikum Heidelberg
RECRUITING

Heidelberg, 69120, Germany
Universitaetsklinikum Wuerzburg
RECRUITING

Würzburg, 97080, Germany
Universitair Medisch Centrum Groningen
RECRUITING

Groningen, 9713 GZ, Netherlands
Universitatsklinikum Jena
RECRUITING

Jena, 07747, Germany
University College London Hospitals
RECRUITING

London, NW1 2PG, United Kingdom
University Health Network UHN Princess Margaret Cancer Centre
RECRUITING

Toronto, Ontario, M5G 2M9, Canada
University of California San Francisco
RECRUITING

San Francisco, California, 94122, United States
University of Connecticut Health Center
RECRUITING

Farmington, Connecticut, 06030, United States
University of Iowa Hospital and Clinics
RECRUITING

Iowa City, Iowa, 52242, United States
University of Kansas Cancer Center
RECRUITING

Kansas City, Kansas, 66160, United States
University of Maryland School of Medicine
RECRUITING

Baltimore, Maryland, 21201, United States
University of North Carolina
RECRUITING

Chapel Hill, North Carolina, 27514, United States
VU Medisch Centrum
RECRUITING

Amsterdam, 1081 HV, Netherlands
Yale Cancer Center
RECRUITING

New Haven, Connecticut, 06510, United States
Yamanashi Prefectural Central Hospital
RECRUITING

Kofu, 400-0027, Japan

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