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New pill targets 'undruggable' cancer mutation in advanced tumors

NCT ID NCT03785249

Ongoing Disease control Sponsor: Mirati Therapeutics Inc. Source: ClinicalTrials.gov ↗

Summary

This trial is testing an experimental pill called MRTX849 (adagrasib) for people with advanced solid tumors that have a specific genetic change called KRAS G12C. The study aims to find safe doses, see how the drug works in the body, and measure if it shrinks tumors. It includes 731 patients whose cancer has spread and who have limited treatment options.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Local Institution - 001-538

    Ocala, Florida, 34474, United States

  • Local Institution - 001-544

    Omaha, Nebraska, 68198, United States

  • Local Institution - 001-544A

    Omaha, Nebraska, 68118, United States

  • Local Institution - 001-544B

    Omaha, Nebraska, 68105-1850, United States

  • Local Institution - 001-554

    Midland, Texas, 79701, United States

  • Local Institution - 001-578

    Los Angeles, California, 90067, United States

  • Local Institution - 001-584

    Tulsa, Oklahoma, 74146, United States

  • Local Institution - 001-586

    Bend, Oregon, 97701, United States

  • Local Institution - 001-586-A

    Bend, Oregon, 97701, United States

  • Local Institution - 001-597

    Fredericksburg, Virginia, 24408, United States

  • Local Institution - 001-600

    Lawton, Oklahoma, 73505, United States

  • Local Institution - 001-779

    Los Alamitos, California, 90720, United States

  • Local Institution - 001-781

    South Bend, Indiana, 46601, United States

  • Local Institution - 001-783

    Media, Pennsylvania, 19063, United States

  • Local Institution - 001-785

    Denison, Texas, 75020, United States

  • Local Institution - 001-801

    Nashville, Tennessee, 37203, United States

  • Local Institution - 001-801-A

    Hendersonville, Tennessee, 37075, United States

  • Local Institution - 001-801-B

    Nashville, Tennessee, 37203, United States

  • Local Institution - 001-801-C

    Nashville, Tennessee, 37211, United States

  • Local Institution - 001-801-D

    Hermitage, Tennessee, 37076, United States

  • Local Institution - 001-801-E

    Nashville, Tennessee, 37207, United States

  • Local Institution - 001-801-F

    Murfreesboro, Tennessee, 37129, United States

  • Local Institution - 001-801-G

    Gallatin, Tennessee, 37066, United States

  • Local Institution - 001-802

    San Antonio, Texas, 78229, United States

  • Local Institution - 001-803

    Orange, California, 92868, United States

  • Local Institution - 001-804

    Madison, Wisconsin, 53792, United States

  • Local Institution - 001-805

    La Jolla, California, 92093, United States

  • Local Institution - 001-806

    New York, New York, 10065, United States

  • Local Institution - 001-808

    Boston, Massachusetts, 02215, United States

  • Local Institution - 001-809

    Dallas, Texas, 75230, United States

  • Local Institution - 001-810

    Aurora, Colorado, 80045, United States

  • Local Institution - 001-811

    Detroit, Michigan, 48202, United States

  • Local Institution - 001-812

    Chapel Hill, North Carolina, 27514, United States

  • Local Institution - 001-813

    New York, New York, 10016, United States

  • Local Institution - 001-814

    Fairfax, Virginia, 22031, United States

  • Local Institution - 001-815

    Buffalo, New York, 14203, United States

  • Local Institution - 001-816

    New Haven, Connecticut, 06510, United States

  • Local Institution - 001-817

    Hershey, Pennsylvania, 17033-0850, United States

  • Local Institution - 001-818

    Cleveland, Ohio, 44195, United States

  • Local Institution - 001-819

    Charleston, South Carolina, 29425, United States

  • Local Institution - 001-820

    Westwood, Kansas, 66205, United States

  • Local Institution - 001-821

    Phoenix, Arizona, 85054, United States

  • Local Institution - 001-822

    Minneapolis, Minnesota, 55455, United States

  • Local Institution - 001-822-A

    Minneapolis, Minnesota, 55455, United States

  • Local Institution - 001-823

    Cincinnati, Ohio, 45267, United States

  • Local Institution - 001-824

    Seattle, Washington, 98109, United States

  • Local Institution - 001-825

    Miami Beach, Florida, 33140, United States

  • Local Institution - 001-826

    Birmingham, Alabama, 35294, United States

  • Local Institution - 001-827

    Biddeford, Maine, 04005, United States

  • Local Institution - 001-829

    Jacksonville, Florida, 32224, United States

  • Local Institution - 001-830

    Rochester, Minnesota, 55905, United States

  • Local Institution - 001-831

    Iowa City, Iowa, 52242, United States

  • Local Institution - 001-833

    Columbus, Ohio, 43210, United States

  • Local Institution - 001-833 - A

    Columbus, Ohio, 43210, United States

  • Local Institution - 001-833 - B

    Columbus, Ohio, 43221, United States

  • Local Institution - 001-833 - C

    Columbus, Ohio, 43203, United States

  • Local Institution - 001-833 - D

    Columbus, Ohio, 43212, United States

  • Local Institution - 001-833 - E

    Gahanna, Ohio, 43230, United States

  • Local Institution - 001-833 - F

    Columbus, Ohio, 43210, United States

  • Local Institution - 001-833 - G

    Columbus, Ohio, 43221, United States

  • Local Institution - 001-833 - H

    Columbus, Ohio, 43201, United States

  • Local Institution - 001-833 - I

    Columbus, Ohio, 43212, United States

  • Local Institution - 001-833 - J

    Columbus, Ohio, 43203, United States

  • Local Institution - 001-834

    Beverly Hills, California, 90211, United States

  • Local Institution - 001-835

    Marietta, Georgia, 30060, United States

  • Local Institution - 001-835-A

    Cartersville, Georgia, 30121, United States

  • Local Institution - 001-835-B

    Douglasville, Georgia, 30134, United States

  • Local Institution - 001-835-C

    Austell, Georgia, 30106, United States

  • Local Institution - 001-835-D

    Carrollton, Georgia, 30117, United States

  • Local Institution - 001-835-E

    Austell, Georgia, 30106, United States

  • Local Institution - 001-835-F

    Carrollton, Georgia, 30117, United States

  • Local Institution - 001-836

    Kettering, Ohio, 45429, United States

  • Local Institution - 001-836-A

    Kettering, Ohio, 45429, United States

  • Local Institution - 001-837

    Allentown, Pennsylvania, 18103, United States

  • Local Institution - 001-837-A

    Bethlehem, Pennsylvania, 18017, United States

  • Local Institution - 001-838

    Saint Louis Park, Minnesota, 55416, United States

  • Local Institution - 001-838-A

    Saint Paul, Minnesota, 55101, United States

  • Local Institution - 001-838-B

    Saint Louis Park, Minnesota, 55426-5000, United States

  • Local Institution - 001-838-C

    Minneapolis, Minnesota, 55404, United States

  • Local Institution - 001-838-D

    Maplewood, Minnesota, 55109, United States

  • Local Institution - 001-838-E

    Edina, Minnesota, 55435, United States

  • Local Institution - 001-838-F

    Coon Rapids, Minnesota, 55433, United States

  • Local Institution - 001-838-G

    Minneapolis, Minnesota, 55415, United States

  • Local Institution - 001-839

    Boca Raton, Florida, 33432, United States

  • Local Institution - 001-840

    Los Angeles, California, 90027, United States

  • Local Institution - 001-840-A

    San Diego, California, 92120, United States

  • Local Institution - 001-840-B

    Bellflower, California, 90706, United States

  • Local Institution - 001-840-C

    Harbor City, California, 90710, United States

  • Local Institution - 001-841

    Billings, Montana, 59102, United States

  • Local Institution - 001-842

    Detroit, Michigan, 48201, United States

  • Local Institution - 001-842-A

    Farmington Hills, Michigan, 48334, United States

  • Local Institution - 001-843

    Duarte, California, 91010, United States

  • Local Institution - 001-844

    Lexington, Kentucky, 40536, United States

  • Local Institution - 001-845

    San Diego, California, 92111, United States

  • Local Institution - 001-846

    Grand Junction, Colorado, 81501, United States

  • Local Institution - 001-847

    Newport Beach, California, 92663, United States

  • Local Institution - 001-848

    Houston, Texas, 77030, United States

  • Local Institution - 001-848a

    Conroe, Texas, 77384, United States

  • Local Institution - 001-850

    Vallejo, California, 94589, United States

  • Local Institution - 001-850-A

    San Leandro, California, 94577, United States

  • Local Institution - 001-850-B

    Oakland, California, 94611, United States

  • Local Institution - 001-850-C

    Roseville, California, 95661, United States

  • Local Institution - 001-850-D

    Sacramento, California, 95825, United States

  • Local Institution - 001-850-E

    San Francisco, California, 94115, United States

  • Local Institution - 001-850-F

    San Jose, California, 95119, United States

  • Local Institution - 001-850-G

    Walnut Creek, California, 94596, United States

  • Local Institution - 001-850-H

    San Francisco, California, 94080, United States

  • Local Institution - 001-850-I

    Santa Clara, California, 95051, United States

  • Local Institution - 001-850-J

    Sacramento, California, 95814, United States

  • Local Institution - 001-850-K

    Dublin, California, 94568, United States

  • Local Institution - 001-851

    Fullerton, California, 92835, United States

  • Local Institution - 001-860

    Henderson, Nevada, 89074, United States

  • Local Institution - 001-860A

    Henderson, Nevada, 89052, United States

  • Local Institution - 001-860B

    Henderson, Nevada, 89074, United States

  • Local Institution - 001-860C

    Henderson, Nevada, 89052, United States

  • Local Institution - 001-860D

    Las Vegas, Nevada, 89144, United States

  • Local Institution - 001-860E

    Las Vegas, Nevada, 89128, United States

  • Local Institution - 001-860F

    Las Vegas, Nevada, 89148, United States

  • Local Institution - 001-861

    Albany, New York, 12206, United States

  • Local Institution - 001-862

    Chicago Ridge, Illinois, 60415, United States

  • Local Institution - 001-870

    Miami, Florida, 33176, United States

  • Local Institution - 001-871

    Newark, Delaware, 19713-2055, United States

  • Local Institution - 001-872

    Aurora, Colorado, 80012, United States

  • Local Institution - 001-872-A

    Lakewood, Colorado, 80228, United States

  • Local Institution - 001-872-B

    Denver, Colorado, 80218, United States

  • Local Institution - 001-872-C

    Longmont, Colorado, 80501, United States

  • Local Institution - 001-872-D

    Littleton, Colorado, 80218, United States

  • Local Institution - 001-872-E

    Colorado Springs, Colorado, 80907, United States

  • Local Institution - 001-872-F

    Pueblo, Colorado, 81008, United States

  • Local Institution - 001-872-G

    Pueblo, Colorado, 81008, United States

  • Local Institution - 001-872-H

    Boulder, Colorado, 80303, United States

  • Local Institution - 001-872-I

    Thornton, Colorado, 80260, United States

  • Local Institution - 001-872-J

    Parker, Colorado, 80138, United States

  • Local Institution - 001-872-K

    Lone Tree, Colorado, 80124, United States

  • Local Institution - 001-872-L

    Colorado Springs, Colorado, 80920, United States

  • Local Institution - 001-873

    Tucson, Arizona, 85704, United States

  • Local Institution - 001-873-A

    Tucson, Arizona, 85704, United States

  • Local Institution - 001-874

    Sugar Land, Texas, 77479, United States

  • Local Institution - 001-875

    Minneapolis, Minnesota, 55404, United States

  • Local Institution - 001-875 - A

    Maplewood, Minnesota, 55109, United States

  • Local Institution - 001-875 - B

    Saint Paul, Minnesota, 55102, United States

  • Local Institution - 001-875 - C

    Woodbury, Minnesota, 55125, United States

  • Local Institution - 001-875 - D

    Edina, Minnesota, 55435, United States

  • Local Institution - 001-876

    Fort Worth, Texas, 76104, United States

  • Local Institution - 001-877

    Pensacola, Florida, 32503, United States

  • Local Institution - 001-878

    Tyler, Texas, 75702, United States

  • Local Institution - 001-879

    Dallas, Texas, 75246, United States

  • Local Institution - 001-880

    Austin, Texas, 78731, United States

  • Local Institution - 001-881

    Columbia, Maryland, 21044, United States

  • Local Institution - 001-881-A

    Silver Spring, Maryland, 20904, United States

  • Local Institution - 001-881-B

    Brandywine, Maryland, 20613, United States

  • Local Institution - 001-882

    Newport News, Virginia, 23606, United States

  • Local Institution - 001-882-A

    Norfolk, Virginia, 23502, United States

  • Local Institution - 001-883

    Niles, Illinois, 60714, United States

  • Local Institution - 001-884

    Santa Barbara, California, 93105, United States

  • Local Institution - 001-884-A

    Solvang, California, 93463, United States

  • Local Institution - 001-885

    Vancouver, Washington, 98684, United States

  • Local Institution - 001-886

    Dallas, Texas, 75231, United States

  • Local Institution - 001-887

    Charleston, South Carolina, 29414, United States

  • Local Institution - 001-888

    Arlington, Texas, 76012, United States

  • Local Institution - 001-888-B

    Arlington, Texas, 76012, United States

  • Local Institution - 001-889

    Eugene, Oregon, 97401, United States

  • Local Institution - 001-890

    Waco, Texas, 76712, United States

  • Local Institution - 001-890-A

    Norfolk, Virginia, 23502, United States

  • Local Institution - 001-900

    San Juan, PR, 00935, Puerto Rico

  • Local Institution - 001-914

    Orange City, Florida, 32763, United States

  • Local Institution - 001-920

    Baton Rouge, Louisiana, 70809, United States

  • Local Institution - 001-922

    Fort Myers, Florida, 33901, United States

  • Local Institution - 001-922A

    Bonita Springs, Florida, 34135, United States

  • Local Institution - 001-922B

    Fort Myers, Florida, 33905, United States

  • Local Institution - 001-922C

    Fort Myers, Florida, 33908, United States

  • Local Institution - 001-922D

    Bradenton, Florida, 34211, United States

  • Local Institution - 001-922E

    Cape Coral, Florida, 33909, United States

  • Local Institution - 001-922F

    Naples, Florida, 34102, United States

  • Local Institution - 001-922G

    Naples, Florida, 34102, United States

  • Local Institution - 001-922H

    Port Charlotte, Florida, 33980, United States

  • Local Institution - 001-922I

    Sarasota, Florida, 34232, United States

  • Local Institution - 001-922J

    Sarasota, Florida, 34236, United States

  • Local Institution - 001-922K

    Venice, Florida, 34285, United States

  • Local Institution - 001-922L

    Venice, Florida, 34292, United States

  • Local Institution - 001-926

    West Palm Beach, Florida, 33401, United States

  • Local Institution - 001-926a

    Wellington, Florida, 33414, United States

  • Local Institution - 001-926b

    Daytona Beach, Florida, 32117, United States

  • Local Institution - 001-926c

    Vero Beach, Florida, 32960, United States

  • Local Institution - 001-926d

    Stuart, Florida, 34994, United States

  • Local Institution - 001-929

    St. Petersburg, Florida, 33705, United States

  • Local Institution - 001-929a

    St. Petersburg, Florida, 33705, United States

  • Local Institution - 001-929b

    Gainesville, Florida, 32605, United States

  • Local Institution - 001-929c

    Brandon, Florida, 33511, United States

  • Local Institution - 001-929d

    Tampa, Florida, 33607, United States

  • Local Institution - 001-929e

    Largo, Florida, 33770, United States

  • Local Institution - 001-929f

    Trinity, Florida, 34655, United States

  • Local Institution - 001-929g

    Clearwater, Florida, 33761, United States

  • Local Institution - 001-929h

    Spring Hill, Florida, 34608, United States

  • Local Institution - 001-929i

    Altamonte Springs, Florida, 32701, United States

  • Local Institution - 001-929j

    Orange City, Florida, 32763, United States

  • Local Institution - 001-929k

    Tavares, Florida, 32778, United States

  • Local Institution - 001-929l

    Orlando, Florida, 32806, United States

  • Local Institution - 001-929m

    Lady Lake, Florida, 32159, United States

  • Local Institution - 001-929n

    Lecanto, Florida, 34461, United States

  • Local Institution - 001-929o

    Winter Park, Florida, 32789, United States

  • Local Institution - 001-929p

    Ocala, Florida, 34474, United States

  • Local Institution - 001-930

    Columbus, Ohio, 43219, United States

  • Local Institution - 001-935

    Kingwood, Texas, 77339, United States

  • Local Institution - 001-935A

    Houston, Texas, 77090, United States

  • Local Institution - 001-935B

    Shenandoah, Texas, 77380, United States

  • Local Institution - 001-935C

    Spring, Texas, 77389, United States

  • Local Institution - 001-935D

    Kingwood, Texas, 77339, United States

  • Local Institution - 001-935E

    Tomball, Texas, 77375, United States

  • Local Institution - 001-950

    Jefferson City, Missouri, 65109, United States

  • Local Institution - 001-951

    Lafayette, Colorado, 80026, United States

  • Local Institution - 001-951 - A

    Denver, Colorado, 80218, United States

  • Local Institution - 001-951 - B

    Denver, Colorado, 80218, United States

  • Local Institution - 001-952

    Bolivar, Missouri, 65613, United States

  • Local Institution - 001-959

    Omaha, Nebraska, 68114, United States

  • Local Institution - 001-965

    Anchorage, Alaska, 99508, United States

  • Local Institution - 001-966

    Cincinnati, Ohio, 45219, United States

  • Local Institution - 001-967

    Athens, Georgia, 30607, United States

  • Local Institution - 001-968

    Richmond, Virginia, 23229, United States

  • Local Institution - 001-969

    Houston, Texas, 77030, United States

  • Local Institution - 001-971

    Pinehurst, North Carolina, 28374, United States

  • Local Institution - 001-999

    Irving, Texas, 75063, United States

Conditions

Explore the condition pages connected to this study.

ADVANCED CANCER MALIGNANT NEOPLASTIC DISEASE METASTATIC CANCER