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A Needle-Free future for kidney diagnosis?

NCT ID NCT06210555

Knowledge-focused Sponsor: Patrick Schjelderup Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 20, 2026 · Last updated Aug 28, 2026 · Updated 3 times

Summary

This study explores whether a special type of MRI, called multiparametric MRI, can detect kidney scarring (fibrosis) without the need for an invasive biopsy. Researchers will follow living kidney donors, transplant recipients, and healthy volunteers over two years, comparing MRI measurements with standard tests of kidney function and biopsy results. The goal is to see if MRI can reliably predict kidney decline and fibrosis, potentially offering a safer, more comprehensive diagnostic tool.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Multiparametric MRI (mpMRI) as a diagnostic imaging technique
What this could lead to
If successful, this could lead to a non-invasive way to diagnose kidney fibrosis, replacing the need for biopsies and enabling earlier detection of kidney damage.
What could go wrong
This is an observational study, so it won't directly test a treatment. MRI measures may not correlate strongly enough with biopsy results, and the small sample size may limit generalizability.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 96 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2024

Expected to finish

Dec 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Prospective cohort of living kidney donors, recipients and healthy controls. Donors and recipients will be recruited from the Departments of Renal Medicine at Aalborg- and Aarhus University Hospital. Healthy controls will be matched by age and sex to living kidney donors. Based on power calculations we aim to include 32 participants in each cohort. Inclusion period of 2 years is expected and 2 years of follow-up planned.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Living kidney donors and transplant recipients: Inclusion Criteria: * Approved as a living kidney donor or recipient of a kidney from a living donor. * Able to cooperate to an MRI examination Exclusion Criteria: * Contraindications to MRI due to incompatible foreign objects. * Severe claustrophobia Healthy controls: Inclusion Criteria: * Office BP \< 140/90 mmHg. (use of 1 antihypertensive drug allowed) * Normal eGFR. (CKD-EPI) * Urine albumin-to-creatinine ratio \< 30 mg/g. * Dipstick negative for hematuria and proteinuria. * Able to cooperate to an MRI examination. Exclusion Criteria: * Contraindications to MRI due to incompatible foreign objects. * Severe claustrophobia. * Pregnancy. * Condition(s) that would exclude living kidney donation.

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Conditions

The condition(s) this trial relates to.

Fibrosis renal fibrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Kidney transplantation Living donors Multiparametric magnetic resonance imaging Renal fibrosis Senescence

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Department of Nephrology, Aalborg University Hospital

    RECRUITING

    Aalborg, North Denmark, 9200, Denmark

  • Department of Renal Medicine, Aarhus University Hospital

    RECRUITING

    Aarhus, Central Jutland, 8200, Denmark

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