Smart combo therapy aims to wipe out hidden myeloma cells

NCT ID NCT06353022

First seen Mar 17, 2026 · Last updated May 08, 2026 · Updated 10 times

Summary

This study tests whether adding T-cell redirecting drugs (teclistamab and talquetamab) to standard therapy can eliminate remaining cancer cells in people with newly diagnosed multiple myeloma. About 103 adults under 66 will receive one of two drug combinations based on their minimal residual disease (MRD) status. The goal is to achieve and maintain a deep remission, but ongoing treatment is needed, so this is a disease control strategy, not a cure.

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Contacts and locations

Locations

  • APHP Hôpital La Pitié Salpétrière

    Paris, 75013, France

  • APHP Hôpital Saint-Antoine

    Paris, 75012, France

  • CH Lyon Sud

    Lyon, 69495, France

  • CH de la Côte Basque

    Bayonne, 64109, France

  • CHRU DIjon

    Dijon, 21000, France

  • CHRU LILLE - Hôpital Claude Huriez

    Lille, 59037, France

  • CHRU Nancy - Hôpitaux de Brabois

    Vandœuvre-lès-Nancy, 54511, France

  • CHRU Rennes - Hôpital de Pontchaillou

    Rennes, 35033, France

  • CHU BORDEAUX - Hôpital du Haut Lévêque

    Pessac, 33604, France

  • CHU Caen

    Caen, 14033, France

  • CHU Limoges

    Limoges, 87000, France

  • CHU Montpellier

    Montpellier, 34295, France

  • CHU Poitiers

    Poitiers, 86000, France

  • CHU Toulouse

    Toulouse, 31059, France

  • CHU Tours Hôpital Bretonneau

    Tours, 37044, France

  • CHU de Nantes

    Nantes, 44093, France

  • CHU de Strasbourg (HUS)

    Strasbourg, 67200, France

  • Chd Vendee

    La Roche-sur-Yon, 85925, France

  • IPC Marseille Institut Paoli Calmettes

    Marseille, 13009, France

Conditions

Explore the condition pages connected to this study.