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Unlocking the Brain's role in relearning movement for MS patients

NCT ID NCT03404388

Knowledge-focused Sponsor: Wayne State University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled This study
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 19, 2026 · Last updated Aug 20, 2026 · Updated 1 time

Summary

This study explores why some people with multiple sclerosis (MS) improve more than others with rehabilitation. Researchers will test whether thinking speed and the integrity of specific brain pathways influence how well participants learn a new balance task. About 146 adults with relapsing-remitting MS will undergo brain imaging, cognitive tests, and balance training over several days. The goal is to identify key factors that predict successful motor skill learning, which could lead to more personalized rehabilitation strategies.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Balance training (a challenging balance task performed over 4 days)
What this could lead to
If successful, this could help predict which people with MS are most likely to benefit from rehabilitation, leading to more personalized therapy plans.
What could go wrong
This is an early mechanistic study, not a treatment trial. It may not identify clear predictors, and results may not apply to all people with MS.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Started

Apr 2020

Finished

Aug 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Diagnosis of Relapsing-Remitting MS, 2. Patient Determined Disease Steps (PDDS) \<6.5, indicating ability to ambulate with or without an assistive device (Hohol, 1999; Learmonth, 2013) 3. between the ages of 18 and 65; 4. stable medication regime for 3 months prior to enrollment, and 5. able to follow study-related commands. Exclusion Criteria: 1. history of other neurological or neuromuscular conditions, 2. acute orthopedic conditions that prevent participation in the training, 3. steroid use \<30 days prior to enrollment; 4. history of alcohol abuse; 5. presence of metallic implants, medical implants or exposure to metallic shrapnel incompatible with MRI, 6. pregnancy; 7. history of hospitalization for depression; and 8. depression as evidenced by a score of ≥10 on the Patient Health Questionnaire-9 (PHQ-9) (Kroenke, 2001), as depression has been shown to impact motor learning in persons with neurologic disorders (Subramanian, 2015).

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Conditions

The condition(s) this trial relates to.

multiple sclerosis relapsing-remitting multiple sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Multiple sclerosis

Contacts and locations

Locations

  • Wayne State University

    Detroit, Michigan, 48201, United States

More trials for these conditions

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