New drug duo aims to tackle tough lymphoma
NCT ID NCT06492837
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial is testing whether combining two drugs, mosunetuzumab and zanubrutinib, can help people with follicular lymphoma whose cancer has returned or stopped responding to previous treatment. The study will enroll 56 participants and measure how many achieve a complete response (cancer disappearance) after treatment. The goal is to find a more effective salvage therapy for this type of blood cancer.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Mosunetuzumab and Zanubrutinib (drug combination)
What this could lead to
If successful, this combination could offer a new, more effective treatment option for people with follicular lymphoma that has returned or not responded to prior therapy.
What could go wrong
This is an early-phase (phase 2) trial with only 56 participants, so results may not apply to everyone. The combination may cause side effects or not work better than existing treatments.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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A.O. Ospedali Riuniti Villa Sofia-Cervello, Divisione di Ematologia
RECRUITINGPalermo, Italy
Contact Email: •••••@•••••
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A.O.U. Città della Salute e della Scienza di Torino, S.C.Ematologia
NOT_YET_RECRUITINGTorino, Italy
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AOU Maggiore della Carità di Novara, SCDU Ematologia
RECRUITINGNovara, Italy
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AOU Ospedali Riuniti, Clinica di Ematologia
RECRUITINGAncona, Italy
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AOU SS. Antonio e Biagio e Cesare Arrigo, SCDU Ematologia
RECRUITINGAlessandria, Italy
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ASST Grande Ospedale Metropolitano Niguarda, SC Ematologia
RECRUITINGMilan, Italy
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ASST Spedali Civili di Brescia, Ematologia
RECRUITINGBrescia, Italy
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Azienda Ospedaliera S.Giuseppe Moscati, S.C. Ematologia e Trapianto emopoietico
RECRUITINGAvellino, Italy
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Azienda Ospedaliera Universitaria Careggi, Unità funzionale di Ematologia
RECRUITINGFlorence, Italy
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Azienda Ospedaliera Universitaria Policlinico - S. Marco, UOC di Ematologia
RECRUITINGCatania, Italy
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Azienda USL Piacenza, UOC Ematologia e Centro Trapianti
RECRUITINGPiacenza, Italy
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Azienda Unitа Sanitaria Locale-IRCCS - Arcispedale Santa Maria Nuova, Ematologia
RECRUITINGReggio Emilia, Italy
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Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Ematologia
RECRUITINGMilan, Italy
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Fondazione IRCCS San Gerardo dei Tintori, Ematologia
RECRUITINGMonza, Italy
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Fondazione del Piemonte per l'Oncologia - IRCCS, Ematologia
RECRUITINGCandiolo, Torino, Italy
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IRCCS Istituto Tumori Giovanni Paolo II, U.O.C Ematologia
RECRUITINGBari, Italy
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Liverpool Hospital
RECRUITINGLiverpool, Australia
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Ospedale Ca' Foncello, S.C di Ematologia
RECRUITINGTreviso, Italy
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Ospedale degli Infermi di Rimini, U.O. di Ematologia
RECRUITINGRimini, Italy
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Policlinico S.Orsola-Malpighi, Istituto di Ematologia "Seragnoli"
RECRUITINGBologna, Italy
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Policlinico Umberto I - Università La Sapienza, Istituto Ematologia, Dipartimento di Medicina Traslazionale e di Precisione
RECRUITINGRoma, Italy
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Princess Alexandra Hospital
RECRUITINGWoolloongabba, Australia
Contact Email: •••••@•••••
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Royal Adelaide Hospital
RECRUITINGAdelaide, Australia
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St. Vincent Hospital Melbourne
RECRUITINGMelbourne, Australia
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