New hope for tough lymphomas: drug duo takes on cancer that resisted treatment
NCT ID NCT05171647
First seen Nov 12, 2025 · Last updated May 07, 2026 · Updated 22 times
Summary
This study tests whether a combination of two drugs (mosunetuzumab and polatuzumab vedotin) works better than standard chemotherapy for people with aggressive B-cell lymphoma that has returned or not responded to prior therapy. About 208 adults with certain types of lymphoma will be randomly assigned to one of the two treatment groups. The goal is to see if the new combo shrinks tumors and delays cancer growth more effectively.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Anadolu Health Center
Kocaeli, 41400, Turkey (Türkiye)
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Ankara University Medical Faculty
Ankara, 06100, Turkey (Türkiye)
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Ascension Seton Infusion Center
Austin, Texas, 78712, United States
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Cancer Center, Sun Yat-sen University of Medical Sciences
Guangzhou, 510060, China
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Chiang Mai Uni Hospital
Chiang Mai, 50200, Thailand
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Chulalongkorn University Hospital
Bangkok, 10330, Thailand
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Chum Hopital Notre Dame
Montreal, Quebec, H2L 4M1, Canada
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Chungnam National University Hospital
Daejeon, 35015, South Korea
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City of Hope Cancer Center
Duarte, California, 91010, United States
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D'or Instituto de Pesquisa e Educação
São Paulo, Brazil
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Dokuz Eylul Universitesi Tip Fakultesi
Lzmir, 35340, Turkey (Türkiye)
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FUNDALEU
Buenos Aires, C1114AAN, Argentina
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Fujian Medical University Union Hospital
Fuzhou, 350001, China
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Hamilton Health Sciences - Juravinski Cancer Centre
Hamilton, Ontario, L8V 5C2, Canada
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Health Pharma Professional Research
Mexico City, Mexico CITY (federal District), 03100, Mexico
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Henan Cancer Hospital
Zhengzhou, 450008, China
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Hokkaido University Hospital
Hokkaido, 060-8648, Japan
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Hospital Aleman
Buenos Aires, 1118, Argentina
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Hospital Erasto Gaertner
Curitiba, Paraná, 81520-060, Brazil
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Hospital Italiano de Buenos Aires
Ciudad Autonoma Buenos Aires, C1181ACH, Argentina
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Hospital Sao Jose
São Paulo, São Paulo, 01323-030, Brazil
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Hospital Universitario Dr. Jose E. Gonzalez
Monterrey, Nuevo León, 64460, Mexico
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Hospital das Clinicas - UFRGS
Porto Alegre, Rio Grande do Sul, 90035-903, Brazil
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Hospital das Clínicas FMRP-USP
Ribeirão Preto, São Paulo, 14048-900, Brazil
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Ichilov Sourasky Medical Center
Tel Aviv, 6423906, Israel
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Instituto Alexander Fleming
Buenos Aires, 1426, Argentina
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Instituto Nacional de Cancerologia
Distrito Federal, 14080, Mexico
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Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
México, Mexico
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Instituto Regional de Enfermedades Neoplásicas del Sur
Arequipa, 5154, Peru
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Kindai University Hospital
Osaka, 589-8511, Japan
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Kyushu University Hospital
Fukuoka, 812-8582, Japan
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MD Anderson Cancer Center
Houston, Texas, 77030, United States
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Middlemore Clinical Trials
Auckland, New Zealand
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Oncosalud Sac
Lima, 41, Peru
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Ondokuz Mayis Univ. Med. Fac.
Samsun, 55139, Turkey (Türkiye)
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Princess Margaret Hospital
Toronto, Ontario, M5G 2M9, Canada
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Pusan National University Hospital
Busan, 49241, South Korea
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Samsung Medical Center
Seoul, 06351, South Korea
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Seoul National University Hospital
Seoul, 03080, South Korea
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Severance Hospital, Yonsei University Health System
Seoul, 03722, South Korea
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Sichuan Cancer Hospital
Chengdu, 610041, China
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Siriraj Hospital
Bangkok, 10700, Thailand
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Soroka Medical Center
Beersheba, 8410101, Israel
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Srinagarind Hospital, Khon Kaen Uni
Khon Kaen, 40002, Thailand
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St. Luke's Hospital
Chesterfield, Missouri, 63017, United States
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Superare Centro de Infusion S.A. de C.V.
Mexico City, Mexico CITY (federal District), 11550, Mexico
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The Cancer Institute Hospital of JFCR
Tokyo, 135-8550, Japan
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Tianjin Cancer Hospital
Tianjin, 300060, China
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Tohoku University Hospital
Miyagi, 980-8574, Japan
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Tongji Hosp, Tongji Med. Col, Huazhong Univ. of Sci. & Tech
Wuhan, 430030, China
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Yamagata University Hospital
Yamagata, 990-9585, Japan
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Yeouido St. Mary's Hospital
Seoul, 07345, South Korea
Conditions
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