New combo shot could tame follicular lymphoma

NCT ID NCT04246086

Ongoing Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests two drugs, mosunetuzumab and lenalidomide, together in people with follicular lymphoma, a type of blood cancer. It includes 237 participants and compares giving one drug as a shot under the skin versus through an IV. The goal is to see if the combination is safe and works better at controlling the cancer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

mosunetuzumab and lenalidomide

What this could lead to

If successful, this combination could offer a new treatment option for people with follicular lymphoma, potentially improving response rates and convenience with a subcutaneous injection.

What could go wrong

This is an early-phase trial (phase 1/2) with a small number of participants, so results may not confirm safety or effectiveness. Side effects from the drugs could be serious.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

follicular lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FOLLICULAR LYMPHOMA

Contacts and locations

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Locations

CHU Rennes - Hopital Pontchaillou

Rennes, 35033, France
Centre Hospitalier Lyon Sud

Pierre-Bénite, 69495, France
City of Hope National Medical Center

Duarte, California, 91010, United States
Cleveland Clinic

Cleveland, Ohio, 44195-0001, United States
Duke University Medical Center

Durham, North Carolina, 27710-4000, United States
Fairview Hospital

Cleveland, Ohio, 44111, United States
Freeman Hospital

Newcastle upon Tyne, NE7 7DN, United Kingdom
Fudan University Shanghai Cancer Center

Shanghai, 200120, China
Hillcrest Hospital

Mayfield Heights, Ohio, 44124, United States
Hospital Universitario Fundacion Jimenez Diaz.

Madrid, 28040, Spain
Hospital Universitario Virgen de la Victoria

Málaga, 29010, Spain
Mary Bird Perkins Cancer Ctr

Baton Rouge, Louisiana, 70809, United States
Norton Cancer Institute - St. Matthews

Louisville, Kentucky, 40207-4723, United States
Nottingham University Hospitals NHS Trust - City Hospital

Nottingham, NG5 1PB, United Kingdom
Rhode Island Hematology/Oncology Program

Woonsocket, Rhode Island, 02895-4720, United States
Swedish Medical Center

Seattle, Washington, 98122, United States
Tennessee Oncology PLLC - Franklin

Franklin, Tennessee, 37067, United States
Tennessee Oncology;Chattanooga Oncology & Hematology Associates

Chattanooga, Tennessee, 37404, United States
The Christie NHS Foundation Trust

Manchester, M20 4BX, United Kingdom
The First Affiliated Hospital of Xiamen University

Xiamen, 361003, China
The First Hospital of Jilin University

Changchun, 130021, China
Tianjin Medical University Cancer Institute & Hospital

Tianjing, 300060, China
University College London Hospitals NHS Foundation Trust - University College Hospital

London, NW1 2PG, United Kingdom
University of Miami Miller School of Medicine

Miami, Florida, 33136-1002, United States
University of Michigan Comprehensive Cancer Center

Ann Arbor, Michigan, 48109, United States
West China Hospital, Sichuan University

Chengdu, 610041, China