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Baby brain study: does Mom's weight matter?

NCT ID NCT04274140

Knowledge-focused Sponsor: Arkansas Children's Hospital Research Institute Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how a mother's weight during pregnancy might affect her baby's brain development. Researchers will follow 260 pregnant women (some with normal weight, some with obesity) and scan their babies' brains with MRI at 2 weeks, 1 year, and 2 years old. They will also test the babies' development to see if there are any differences linked to the mother's weight.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could reveal how a mother's weight during pregnancy influences her baby's brain growth, pointing to ways to support healthy development.
What could go wrong
This is an observational study, not a treatment trial. It may find no clear link, or results may not apply to all populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 260 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2019

Expected to finish

Oct 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

We will recruit 260 pregnant women (N=130 for normal weight, BMI 18.5-25, and N=130 for obese, BMI 30-50) at \<12 weeks of pregnancy. This is an increase of sample size from the previous number of 120 normal weight women and 120 obese women. The reason is that due to a pandemic, a series factors (such as suspension of all clinical research visits; participants skipping research visits because of COVID concerns) have resulted in that we were not able to get complete data from some of the enrolled subjects at some time points. Our goal is still to obtain complete neuroimaging and maternal clinical data from 120children (N=60/60 from normal-weight or obese mothers) at age \~2 years. .

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Singleton pregnancy * 11-13 weeks of gestation -≥18 years of age. Exclusion Criteria: * BMI measured at first study visit \<18.5 or between 26-29 or \>50 * hypertension, diabetes, or other preexisting medical conditions known or suspect (by the research team) to influence fetal growth; * family history of psychological or neurogenetic disorders as determined by the research team that may increase the risk of adverse neurodevelopmental outcomes in offspring * medications known to influence fetal growth * recreational drugs, nicotine or tobacco (including smokeless) use or alcohol use while pregnant * medical conditions developed during pregnancy (e.g. gestational diabetes, preeclampsia) known or suspected by the research team to influence fetal growth * infants born preterm (\<37 weeks of gestation), with congenital defects, intrauterine growth restriction, small for gestational age, macrosomia, hypoglycemia, low Apgar score (\<7), or any other medical complications at birth suspected affecting development

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy

Contacts and locations

Locations

  • Arkansas Children's Nutrition Center

    Little Rock, Arkansas, 72202, United States

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