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Can a contact lens improve clarity during retinal surgery?

NCT ID NCT07807436

Disease control Sponsor: Northwest University First Hospital (Xi'an No.1 Hospital) Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 08, 2026 · Last updated Sep 09, 2026 · Updated 1 time

Summary

This trial tests whether a modified soft contact lens placed on the cornea during vitrectomy, a surgery for retinal disease, keeps the surgical view clearer than the standard method of intermittent saline irrigation. Researchers randomly assign 46 participants to receive either the lens or standard irrigation during their surgery. They grade how clear the surgical field is, how often irrigation is needed, and the duration of the operation. Participants are followed for one month after surgery to check for any effects on the cornea.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
A modified soft contact lens placed on the cornea during vitrectomy surgery
What this could lead to
If the lens works, it could offer a simpler way to keep the surgical view clear and protect the cornea during vitrectomy, potentially improving outcomes for people with retinal disease.
What could go wrong
This is a small, early-stage trial, so the lens may not prove better than standard irrigation. Risks include corneal irritation or infection from the lens, though the study excludes people with pre-existing ocular surface disease.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

46 people

The number who actually took part.

Started

Apr 2022

Finished

Jan 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosis of a retinal disease requiring pars plana vitrectomy. * Corneal endothelial cell density of at least 2,000 cells/mm². * No ocular surface disease or significant anterior-segment abnormality. * No ocular surgery or trauma within the previous month, except intravitreal anti-VEGF injection. * Considered suitable for ophthalmic surgery under routine clinical conditions. Exclusion Criteria: * Refusal to participate or withdrawal from the study. * Syncope or inability to tolerate study examinations or surgery. * Incomplete study data. * Any condition judged by the investigator to interfere with corneal assessment, including corneal edema secondary to persistently elevated intraocular pressure.

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Conditions

The condition(s) this trial relates to.

retinal disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Retinal disease

Contacts and locations

Locations

  • Xi'an First Hospital

    Xi'an, Shaanxi, 710002, China

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