Heart valve study challenges Watch-and-Wait approach for millions

NCT ID NCT04889872

Recruiting now Disease control Sponsor: Edwards Lifesciences Source: ClinicalTrials.gov ↗

Summary

This study aims to determine whether early valve replacement or careful monitoring works better for older adults with moderate aortic valve narrowing. Researchers will compare two approaches: implanting a new heart valve through a minimally invasive procedure versus regular check-ups and monitoring. The trial will help doctors understand if treating moderate valve problems earlier improves survival and reduces hospital visits for heart failure.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

AMC Amsterdam
ACTIVE_NOT_RECRUITING

Amsterdam, North Holland, 1105 AZ, Netherlands
Alexian Brothers Hospital
RECRUITING

Lisle, Illinois, 60532, United States
Allegheny Singer Research Institute
RECRUITING

Pittsburgh, Pennsylvania, 15212, United States
Ascension Texas Cardiovascular
RECRUITING

Austin, Texas, 78705, United States
Ascension Via Christi St. Francis
RECRUITING

Wichita, Kansas, 67226, United States
Atlantic Health System Hospital Corp - Morristown Medical Center
RECRUITING

Morristown, New Jersey, 07960, United States
Baptist Health Research Center
RECRUITING

Jacksonville, Florida, 32207, United States
Baptist Memorial Hospital Memphis
RECRUITING

Germantown, Tennessee, 38138, United States
Bay Area Structural Heart at Sutter Health
RECRUITING

San Francisco, California, 94109, United States
Cedars-Sinai Medical Center
RECRUITING

Los Angeles, California, 90048, United States
CentraCare Heart and Vascular Center
RECRUITING

Saint Cloud, Minnesota, 56303, United States
Columbia University Irving Medical Center/NYPH
ACTIVE_NOT_RECRUITING

New York, New York, 10032, United States
Eisenhower Desert Cardiology Center
RECRUITING

Rancho Mirage, California, 92270, United States
Emory University Atlanta
RECRUITING

Atlanta, Georgia, 30308, United States
Erasmus Rotterdam
ACTIVE_NOT_RECRUITING

Rotterdam, South Holland, 3015, Netherlands
Flinders Medical Centre
ACTIVE_NOT_RECRUITING

Bedford Park, South Australia, 5042, Australia
HCA Houston Healthcare Medical Center
RECRUITING

Houston, Texas, 77004, United States
Hamiton Health Services
ACTIVE_NOT_RECRUITING

Hamilton, Onterio, L8L 2X2, Canada
Heart Center LLC, Huntsville
RECRUITING

Huntsville, Alabama, 35801, United States
Huntington Hospital
WITHDRAWN

Pasadena, California, 91105, United States
Hôpitaux Universitaire de Genève
ACTIVE_NOT_RECRUITING

Geneva, 1205, Switzerland
Jersey Shore University Medical Center
RECRUITING

Neptune City, New Jersey, 07753, United States
Kaiser Mid Atlantic
RECRUITING

McLean, Virginia, 22102, United States
Kaiser Permanente Northwest
ACTIVE_NOT_RECRUITING

Clackamas, Oregon, 97015, United States
Kaiser San Francisco Medical Center
ACTIVE_NOT_RECRUITING

San Francisco, California, 94118, United States
Keio University Hospital
ACTIVE_NOT_RECRUITING

Shinjuku, Tokyo, 160-8582, Japan
Kokura Memorial Hospital
ACTIVE_NOT_RECRUITING

Fukuoka, Kyushu, 802-8555, Japan
Lankenau Medical Center
RECRUITING

Wynnewood, Pennsylvania, 19096, United States
Legacy Emanuel Medical Center
RECRUITING

Portland, Oregon, 97227, United States
Leiden Universitair Medisch Centrum
ACTIVE_NOT_RECRUITING

Leiden, South Holland, 2333, Netherlands
Louisiana State University
RECRUITING

New Orleans, Louisiana, 70112, United States
Mary Hitchcock Memorial Hospital
RECRUITING

Lebanon, New Hampshire, 03756, United States
Massachusetts General Hospital Boston
RECRUITING

Boston, Massachusetts, 02114, United States
Methodist Hospital of San Antonio
ACTIVE_NOT_RECRUITING

San Antonio, Texas, 78229, United States
Methodist Le Bonheur Healthcare
RECRUITING

Germantown, Tennessee, 38138, United States
Minneapolis Heart Institue, St. Paul's
RECRUITING

Minneapolis, Minnesota, 55102, United States
Monash Health
ACTIVE_NOT_RECRUITING

Clayton, Victoria, 3168, Australia
Montefiore Medical Center
RECRUITING

The Bronx, New York, 10467, United States
Moses Cone Memorial Hospital
RECRUITING

Greensboro, North Carolina, 27401, United States
Mount Carmel Health System
ACTIVE_NOT_RECRUITING

Columbus, Ohio, 43213, United States
NYU Langone Health
WITHDRAWN

New York, New York, 10016, United States
NYU Langone Hospital - Long Island
RECRUITING

Mineola, New York, 11501, United States
Ochsner Clinical Foundation
ACTIVE_NOT_RECRUITING

New Orleans, Louisiana, 70121, United States
Oklahoma Heart Institute
RECRUITING

Tulsa, Oklahoma, 74104, United States
Parkwest Medical Center
RECRUITING

Knoxville, Tennessee, 37923, United States
Piedmont Heart Institute
RECRUITING

Atlanta, Georgia, 30309, United States
Pinnacle Health Harrisburg
ACTIVE_NOT_RECRUITING

Wormleysburg, Pennsylvania, 17043, United States
Providence Heart & Vascular Institute Portland
WITHDRAWN

Portland, Oregon, 97225, United States
Rochester General Hospital
RECRUITING

Rochester, New York, 14621, United States
Royal Adelaide Hospital
ACTIVE_NOT_RECRUITING

Adelaide, South Australia, 5000, Australia
Rush University Medical Center
RECRUITING

Chicago, Illinois, 60612, United States
Rutgers Robert Wood Johnson Medical School
RECRUITING

New Brunswick, New Jersey, 08901, United States
Saint Alphonsus
RECRUITING

Boise, Idaho, 83704, United States
Saint Luke's Hospital of Kansas City Mid America
RECRUITING

Kansas City, Missouri, 64111, United States
Saint Thomas Health
RECRUITING

Nashville, Tennessee, 37205, United States
Sakakibara Heart Institute
ACTIVE_NOT_RECRUITING

Fuchū, Tokyo, 183-0003, Japan
Santa Barbara Cottage Hospital
RECRUITING

Santa Barbara, California, 93105, United States
Sarasota Memorial Health Care System
RECRUITING

Sarasota, Florida, 34239, United States
Sendai Kousei Hospital
ACTIVE_NOT_RECRUITING

Sendai, Miyagi, 981-0914, Japan
Sentara Norfolk General Hospital
RECRUITING

Norfolk, Virginia, 23507, United States
St. Francis Hospital
RECRUITING

Roslyn, New York, 11576, United States
St. Patrick Hospital
ACTIVE_NOT_RECRUITING

Missoula, Montana, 59802, United States
St. Paul's Hospital
ACTIVE_NOT_RECRUITING

Vancouver, British Columbia, V6E1M7, Canada
Stanford Univeristy
RECRUITING

Stanford, California, 94305, United States
Swedish Medical Center
RECRUITING

Seattle, Washington, 98112, United States
The Cardiac & Vascular Institute Research Foundation
WITHDRAWN

Gainesville, Florida, 32605, United States
The Christ Hospital
ACTIVE_NOT_RECRUITING

Cincinnati, Ohio, 45219, United States
The Heart Hospital Baylor Plano
RECRUITING

Plano, Texas, 75093, United States
The Prince Charles Hospital
ACTIVE_NOT_RECRUITING

Chermside, Queensland, 4032, Australia
The University of Texas Health Science Center
RECRUITING

Houston, Texas, 77030, United States
The Valley Hospital
RECRUITING

Ridgewood, New Jersey, 07450, United States
Tucson Medical Center
ACTIVE_NOT_RECRUITING

Tucson, Arizona, 85712, United States
UC Health Medical Center of the Rockies
RECRUITING

Loveland, Colorado, 80538, United States
UPMC Presbyterian Shadyside
ACTIVE_NOT_RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
UT Southwestern Medical Center
RECRUITING

Dallas, Texas, 75235, United States
University of Buffalo Kaleida Health
RECRUITING

Buffalo, New York, 14203, United States
University of California San Francisco
RECRUITING

San Francisco, California, 94143, United States
Universitätsspital Zürich
WITHDRAWN

Zurich, 8091, Switzerland
Vanderbilt University Medical Center
RECRUITING

Nashville, Tennessee, 37232, United States
Yale Universtiy
RECRUITING

New Haven, Connecticut, 06510, United States

Conditions

Explore the condition pages connected to this study.

AORTIC STENOSIS, CALCIFIC AORTIC VALVE STENOSIS