Experimental myeloma combo trial halted early

NCT ID NCT05556616

Terminated Disease control Sponsor: Teva Branded Pharmaceutical Products R&D LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage trial tested a new drug called modakafusp alfa (TAK-573) combined with standard myeloma treatments in 15 adults with multiple myeloma. The main goal was to check safety and find the best dose. The study was terminated early, so we have limited information on how well it worked.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: modakafusp alfa (also called TAK-573) given with lenalidomide, bortezomib, carfilzomib, daratumumab, or pomalidomide
What this could lead to: If successful, this could point toward a new combination treatment option for multiple myeloma that may help control the disease.
What could go wrong: This was a very early (phase 1) trial with only 15 participants, and it was terminated early, so results are limited. The drug may cause side effects or not work as hoped.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

plasma cell myeloma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTIPLE MYELOMA

Contacts and locations

Locations

AZ Delta

Roeselare, Roeselare West-Vlaanderen, 8800, Belgium
CHU UCL Namur site Godinne

Yvoir, Namur, 5530, Belgium
Cancer Center At Greater Baltimore Medical Center

Baltimore, Maryland, 21153, United States
Clinica Universidad de Navarra, Dept of Oncology

Pamplona, 31008, Spain
Clinica Universidad de Navarra-Sede Madrid

Madrid, 28027, Spain
Comprehensive Cancer Centers of Nevada

Las Vegas, Nevada, 89119, United States
Gabrail Cancer Center Research

Canton, Ohio, 44718, United States
Hospital Universitario La Fe de Valencia

Valencia, 46026, Spain
Hospital Universitario Virgen de la Victoria

Málaga, 29010, Spain
Icahn School of Medicine at Mount Sinai

New York, New York, 10029, United States
Memorial Sloan Kettering Cancer Center - Main Campus

New York, New York, 10065, United States
NYU Langone Hospital - Long Island

Mineola, New York, 11501, United States
New York University School of Medicine

New York, New York, 10016, United States
Novant Health Cancer Institute

Charlotte, North Carolina, 28204, United States
Novant Health Cancer Institute - Forsyth Medical Center

Winston-Salem, North Carolina, 27103, United States
Rambam Health Care Campus (RHCC) - Meyer Children's Hospital - Pediatric Diabetes & Obesity Clinic

Haifa, 31999, Israel
Scripps Health

San Diego, California, 92121, United States
The University of Iowa Hospitals & Clinics

Iowa City, Iowa, 52242, United States
The University of Texas MD Anderson Cancer Center

Houston, Texas, 77030, United States
University of California Davis Comprehensive Cancer Center

Sacramento, California, 95817, United States
Weill Cornell Medicine/New York Presbyterian Hospital

New York, New York, 10021, United States

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