New study: can a simple clip replace Open-Heart surgery for seniors with leaky heart valves?
NCT ID NCT05051033
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares two ways to fix a leaky mitral valve in people aged 60 and older: a less invasive procedure using a clip (TEER) versus traditional open-heart surgery. About 450 participants will be randomly assigned to one of the two treatments. The goal is to see if the clip works as well as surgery at preventing death, repeat procedures, or worsening of the leak over at least three years.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Mitral valve repair (surgery or transcatheter clip)
What this could lead to
If TEER proves as effective as surgery, older patients could avoid open-heart surgery and recover faster while still controlling their heart valve disease.
What could go wrong
This is a mid-stage trial with 450 participants, so results may not apply to everyone. TEER might not fix the leak as well as surgery, and both procedures carry risks like infection or bleeding.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Asklepios Klinik St. Georg Hamburg
Hamburg, 20099, Germany
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Barts Health NHS Trust
London, E1 8PR, United Kingdom
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Baylor, Scott and White
Dallas, Texas, 75246, United States
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Brigham and Women's
Boston, Massachusetts, 02115, United States
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Cedars Sinai Medical Center
Los Angeles, California, 90048, United States
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Cleveland Clinic
Cleveland, Ohio, 44195, United States
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Dartmouth Hitchcock Medical Center
Lebanon, New Hampshire, 03756, United States
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Deutsches Herzzentrum München
München, 80636, Germany
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Deutsches Herzzentrum der Charité
Berlin, 13353, Germany
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Duke University Hospital
Durham, North Carolina, 27710, United States
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Emory University
Atlanta, Georgia, 30322, United States
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Golden Jubilee University National Hospital
Clydebank, G81 4DY, United Kingdom
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Herz- und Diabeteszentrum NRW
Bad Oeynhausen, North Rhine-Westphalia, 32545, Germany
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Herzzentrum Leipzig
Leipzig, 04289, Germany
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Hospital Alvaro Cunqueiro
Vigo, Galacia, 36204, Spain
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Hospital Central de Asturias
Oviedo, 33011, Spain
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Hospital Clinic De Barcelona
Barcelona, 08036, Spain
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Hospital Clínico San Carlos
Madrid, 28040, Spain
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Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States
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Institut Universitaire de Cardiologie et de Pneumologie de Quebec (Laval University)
Québec, Quebec, QC G1V 4G5, Canada
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Keck Hospital of the University of Southern California
Los Angeles, California, 90033, United States
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Kerckhoff Klinik Bad Nauheim
Bad Nauheim, 61231, Germany
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King's College Hospital NHS Foundation Trust
London, England, SE5 9RS, United Kingdom
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London Health Sciences
London, Ontario, ON N6A 5W9, Canada
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Maine Medical Center
Portland, Maine, 04102, United States
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Manchester University NHS Foundation Trust
Manchester, England, M23 9LT, United Kingdom
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
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Medical University of South Carolina
Charleston, South Carolina, 29425, United States
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New York-Presbyterian/Columbia University Medical Center
New York, New York, 10032, United States
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Northwell Health
New York, New York, 21287, United States
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Ochsner Clinic
New Orleans, Louisiana, 70121, United States
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Oxford University Hospitals NHS Foundation Trust
Headington, OX3 9DU, United Kingdom
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Piedmont Heart Institute
Atlanta, Georgia, 30309, United States
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Royal Brompton and Harefield Guy's and St Thomas' NHS Foundation Trust
London, England, SW3 6NP, United Kingdom
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Royal Papworth Hospital NHS Foundation Trust
Cambridge, England, CB2 0AY, United Kingdom
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Saint Luke's Hospital of Kansas City/MidAmerica Heart and Lung Surgeons
Kansas City, Missouri, 64111, United States
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Schüchtermann-Klinik Bad Rothenfelde
Bad Rothenfelde, 49214, Germany
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South Tees Hospital NHS Foundation Trust
Middlesbrough, United Kingdom
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South Tees Hospitals NHS Foundation Trust
Middlesbrough, TS4 3BW, United Kingdom
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St. Thomas Guy's and St Thomas' NHS Foundation Trust
London, England, SE1 7EH, United Kingdom
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Stanford University
Stanford, California, 94305, United States
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The Johns Hopkins Hospital
Baltimore, Maryland, 21287, United States
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The Leeds Teaching Hospitals NHS Trust
Leeds, England, LS1 3EX, United Kingdom
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Unity Health Toronto (St. Michael's Hospital)
Toronto, Ontario, M5B 1W8St, Canada
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University Hospitals Birmingham NHS Foundation Trust
Birmingham, B15 2TH, United Kingdom
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University Hospitals Sussex NHS Foundation Trust
Worthing, West Sussex, BN2 5BE, United Kingdom
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University of British Columbia, Providence Health Care, St. Paul's Hospital
Vancouver, British Columbia, BC V6E 1M7, Canada
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University of California San Francisco
San Francisco, California, 94143, United States
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University of Michigan Hospital
Ann Arbor, Michigan, 48109, United States
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University of Ottawa Heart Institute
Ottawa, Ontario, K1Y 4W7, Canada
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University of Virginia Medical Center
Charlottesville, Virginia, 22903, United States
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Universitätsklinikum Frankfurt
Frankfurt, 60590, Germany
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Universitätsklinikum Freiburg
Freiburg im Breisgau, 79106, Germany
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Universitätsklinikum Hamburg Eppendorf
Hamburg, 20246, Germany
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Universitätsklinikum Heidelberg
Heidelberg, 69120, Germany
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Universitätsklinikum Jena
Jena, 07747, Germany
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Universitätsklinikum Köln
Cologne, Berlin-kölnische Allee, 50969, Germany
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Universitätsklinikum Köln
Cologne, North Rhine-Westphalia, 50937, Germany
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Universitätsklinikum Schleswig-Holstein Campus Kiel
Kiel, 24105, Germany
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Universitätsklinikum Schleswig-Holstein Campus Lübeck
Lübeck, 23538, Germany
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Weill Cornell Medicine/ New York-Presbyterian Hospital
New York, New York, 10065, United States
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West Virginia University Hospital
Morgantown, West Virginia, 26506, United States