New pill could transform sickle cell treatment

NCT ID NCT05031780

Ongoing Disease control Sponsor: Agios Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

Summary

This clinical trial is testing whether an oral medication called mitapivat can help people with sickle cell disease. Researchers want to see if the drug increases healthy hemoglobin levels in the blood and reduces painful crises compared to a placebo. The study involves 286 participants and includes both short-term testing and long-term follow-up to understand the treatment's effects.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

A.O.R.N. "A. Cardarelli"

Naples, Campania, 80131, Italy
AOU dell'Università degli Studi della Campania Luigi Vanvitelli

Naples, Campania, 80138, Italy
Acibadem Adana Hospital

Seyhan, Adana, 01130, Turkey (Türkiye)
American University of Beirut Medical Center

Beirut, Beyrouth, 11-0236, Lebanon
American University of Beirut Medical Center

Beirut, 4407-2020, Lebanon
Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello

Palermo, Sicily, 90146, Italy
Azienda Ospedaliero Universitaria Di Modena Policlinico

Modena, Emilia-Romagna, 41100, Italy
Boston Children's Hospital

Boston, Massachusetts, 02115-5724, United States
Boston Medical Center & Boston University School of Medicine

Boston, Massachusetts, 02118, United States
CHR de la Citadelle

Liège, 4000, Belgium
CHU Guadeloupe

Pointe à Pitre, Guadeloupe, 97139, France
CHU Hôpital Henri Mondor

Créteil, Val-de-Marne, 94000, France
CHU Montreal

Montreal, Quebec, H2X 3E4, Canada
Cambridge University Hospitals NHS Foundation Trust

Cambridge, CB2 0QQ, United Kingdom
Children's Hospital Oakland

Oakland, California, 94609, United States
Children's Hospital of Michigan

Detroit, Michigan, 48201, United States
Children's National Hospital

Washington D.C., District of Columbia, 20010-2916, United States
Clinique CHC MontLégia

Liège, 4000, Belgium
Cure 4 The Kids Foundation, A Division of Roseman University of Health Sciences

Las Vegas, Nevada, 89106, United States
East Carolina University - Brody School of Medicine

Greenville, North Carolina, 27834, United States
Ente Ospedaliero Ospedali Galliera

Genoa, Liguria, 16128, Italy
Erasmus MC

Rotterdam, South Holland, 3015 GD, Netherlands
Evelina Children's Hospital

London, City of London, SE1 7EH, United Kingdom
Gertrude's Children's Hospital

Nairobi, 42325- 00100, Kenya
Guy's and St Thomas' NHS Foundation Trust

London, SE1 7EH, United Kingdom
HEMORIO Instituto Nacional de Hematologia

Rio de Janeiro, 20211-030, Brazil
HaEmek Medical Center

Afula, 18101, Israel
Hacettepe University

Ankara, Adana, Turkey (Türkiye)
Hammersmith Hospital

London, W12 0HS, United Kingdom
Hammoud Hospital University Medical Center

Sidon, H96G+247, Lebanon
Hopitaux de La Timone

Marseille, Bouches-du-Rhône, 13005, France
Hospital Das Clínicas da Faculdade de Medicina de Ribeirão Preto - USP

Ribeirão Preto, São Paulo, 14051-140, Brazil
Hospital Sao Lucas Da Pontificia Universidade Catolica Do Rio Grande Do Sul (PUCRS)

Porto Alegre, Rio Grande do Sul, 90619-900, Brazil
Hospital das Clínicas da Faculdade de Medicina da Universidad de São Paulo

São Paulo, 05403-010, Brazil
Hospital de Clinicas de Porto Alegre (HCPA) - PPDS

Porto Alegre, Rio Grande do Sul, 90035-903, Brazil
Hospital de Clínicas da Unicamp

Campinas, São Paulo, 13083-878, Brazil
Hôpital Erasme

Anderlecht, Brussels Capital, 1070, Belgium
Hôpital Européen Georges Pompidou

Paris, Île-de-France Region, 75015, France
Hôpital Pellegrin, CHU de Bordeaux

Bordeaux, Gironde, 33000, France
IRCCS Ospedale Pediatrico Bambino Gesù - INCIPIT - PIN

Rome, Lazio, 00165, Italy
Institut Universitaire du Cancer de Toulouse - Oncopole

Toulouse, Haute-Garonne, 31059, France
KEMRI CRDR Clinical Research Clinic Nairobi

Nairobi, 00100, Kenya
KEMRI/CRDR Siaya Clinical Research Annex

Nairobi, 00200, Kenya
Kaiser Permanente - Largo Medical Center

Largo, Maryland, 20774-5374, United States
Kemri Usamru

Kisumu, Western, 40100, Kenya
King Abdullah International Medical Research Center

Riyadh, 1515 (KAIMRC), Saudi Arabia
King Khalid University Hospital

Riyadh, Ar Riya, 11472, Saudi Arabia
King's College Hospital NHS Foundation Trust

London, SE5 9RS, United Kingdom
Kondele Children's Hospital

Kisumu, 40100, Kenya
LSU Health Sciences Center - Shreveport

Shreveport, Louisiana, 71103-4228, United States
Lagos University Teaching Hospital

Surulere, Lagos, 101014, Nigeria
Lifespan at Rhode Island Hospital

Providence, Rhode Island, 02903, United States
Manchester Royal Infirmary, Manchester University NHS Foundation Trust

Manchester, M13 9WL, United Kingdom
Massachusetts General Hospital

Boston, Massachusetts, 02114-2621, United States
McGill University Health Center

Montreal, Quebec, H4A 3J1, Canada
McMaster University - St. Joseph's Healthcare Hamilton

Hamilton, Ontario, L8N 3Z5, Canada
MedStar Washington Hospital Center

Washington D.C., District of Columbia, 20010, United States
Mississippi Center for Advanced Medicine

Madison, Mississippi, 39110-6115, United States
Multihemo Servicos Medicos S/A

Recife, Pernambuco, 50070-460, Brazil
National Heart Lung and Blood Institute

Bethesda, Maryland, 20814, United States
National Hospital Abuja

Abuja, Federal Capital Territory, 900271, Nigeria
Nini Hospital

Tarablus, Mohafazat Liban-Nord, 1434, Lebanon
Penn Medicine - University of Pennsylvania Health System

Philadelphia, Pennsylvania, 19104-5127, United States
Praxis Pesquisa Medica

Santo André, São Paulo, Brazil
Rambam Medical Center

Haifa, Ḥeifā, 31096, Israel
Riley Hospital For Children

Indianapolis, Indiana, 46202-5109, United States
Seattle Cancer Care Alliance, University of Washington

Seattle, Washington, 98195, United States
Southern Specialty Clinic

Flowood, Mississippi, 39232, United States
St. Christopher's Hospital for Children

Philadelphia, Pennsylvania, 19134-1011, United States
Strathmore University

Nairobi, 00200, Kenya
Sultan Qaboos University Hospital, Hematology Department, COM&HS

Muscat, Musqal, H5QC+36M, Oman
Sylvester Comprehensive Cancer Center-Miami

Miami, Florida, 33101, United States
Texas Children's Hospital

Houston, Texas, 77030, United States
UCLA Health

Los Angeles, California, 90095-1678, United States
Universitair Medisch Centrum Utrecht

Utrecht, 3584 CX, Netherlands
Universitair Ziekenhuis Antwerpen

Edegem, Brussels Capital, 2650, Belgium
University College London Hospitals (UCLH)

London, WC1E 6BT, United Kingdom
University Health Network

Toronto, Ontario, M5G2C4, Canada
University of Abuja Teaching Hospital

Abuja, Federal Capital Territory, 900271, Nigeria
University of California San Diego

La Jolla, California, 92037-1337, United States
University of Chicago Medical Center

Chicago, Illinois, 60637-1443, United States
University of Connecticut Health Center

Farmington, Connecticut, 06030-0001, United States
University of Michigan

Ann Arbor, Michigan, 48109-5000, United States
University of Texas Health Science Center of Houston

Houston, Texas, 77030-1501, United States
Universitätsklinikum Essen

Essen, 45147, Germany
Universitätsklinikum Regensburg

Regensburg, 93053, Germany
Victoria Biomedical Research Institute (VIBRI)

Kisumu, 40100, Kenya
Virginia Commonwealth University

Richmond, Virginia, 23298-5058, United States
ZAS Cadix

Antwerp, 2030, Belgium
Ziv Medical Center

Safed, Ḥeifā, 13100, Israel

Conditions

Explore the condition pages connected to this study.

SICKLE CELL DISEASE