Can microneedling with a chemo drug restore skin color in vitiligo?

NCT ID NCT07398807

Recruiting now Disease control Sponsor: Combined Military Hospital (CMH) institute of Medical Sciences Bahawalpur Pakistan Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-stage trial compares two treatments for limited vitiligo: microneedling with 5-fluorouracil (5FU) every two weeks versus a strong steroid cream applied twice daily. Forty participants aged 5 to 70 with vitiligo on 10% or less of their body will be treated for 12 weeks. The goal is to see which approach better restores skin pigment and how satisfied patients are with the results.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: 5-fluorouracil (5FU) applied after microneedling, compared to clobetasol propionate steroid cream
What this could lead to: If it works, this could offer a new treatment option for limited vitiligo that restores skin color without long-term steroid use.
What could go wrong: This is a very early, small trial with only 40 people, so results may not apply to everyone. The microneedling procedure can cause skin irritation or infection, and 5FU may cause redness or burning.

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Conditions

The condition(s) this trial relates to.

vitiligo

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

VITILIGO

Contacts and locations

Locations

CMH Bahawalpur
RECRUITING

Chak Four Hundred Fifty-four, Pakistan

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