New combo aims to tackle Hard-to-Treat myeloma
NCT ID NCT06988488
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests two drugs, mezigdomide and elranatamab, together in people with multiple myeloma that has come back or stopped responding to prior treatments. The goal is to find the safest dose and see if the combination can shrink tumors. About 62 adults will take part in this early-stage trial.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
mezigdomide and elranatamab (with dexamethasone)
What this could lead to
If successful, this combination could offer a new treatment option for people with multiple myeloma that has returned or stopped responding to other therapies.
What could go wrong
This is an early-phase trial with only 62 participants, so results may not apply to everyone. The drugs may cause serious side effects or fail to control the cancer.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Locations
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Alexandra General Hospital of Athens
RECRUITINGAthens, Attikí, 115 28, Greece
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Arthur J E Child Comprehensive Cancer Centre
RECRUITINGCalgary, Alberta, T2N 5G2, Canada
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Evangelismos General Hospital of Athens
RECRUITINGAthens, Attikí, 106 76, Greece
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Hackensack University Medical Center
RECRUITINGHackensack, New Jersey, 07601, United States
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Hospital Universitario Marqués de Valdecilla
RECRUITINGSantander, Cantabria, 39008, Spain
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Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca
RECRUITINGSalamanca, 37007, Spain
Contact Phone: •••-•••-••••
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Local Institution - 0026
NOT_YET_RECRUITINGVancouver, British Columbia, V5Z 4E6, Canada
Contact
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Local Institution - 0030
NOT_YET_RECRUITINGSuzhou, Jiangsu, 215006, China
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Local Institution - 0031
NOT_YET_RECRUITINGShanghai, Shanghai Municipality, 200434, China
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Princess Margaret Cancer Centre
RECRUITINGToronto, Ontario, M5G 2M9, Canada
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QEII Health Sciences Centre - Victoria General Site
RECRUITINGHalifax, Nova Scotia, B3H 2Y9, Canada
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Royal Marsden Hospital (Sutton)
RECRUITINGLondon, Sutton, SM2 5PT, United Kingdom
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St. Olavs Hospital
RECRUITINGTrondheim, Sør-Trøndelag, 7030, Norway
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Sykehusapoteket Ull
RECRUITINGOslo, 0450, Norway
Contact Phone: •••-•••-••••
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The Christie NHS Foundation Trust
RECRUITINGManchester, M20 4BX, United Kingdom
Contact Phone: •••-•••-••••
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Universitaetsklinikum Carl Gustav Carus Dresden
RECRUITINGDresden, 01307, Germany
Contact Phone: •••-•••-••••
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Universitaetsklinikum Hamburg-Eppendorf
RECRUITINGHamburg, 20246, Germany
Contact Phone: •••-•••-••••
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Universitaetsklinikum Heidelberg
RECRUITINGHeidelberg, 69120, Germany
Contact Phone: •••-•••-••••
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University College London Hospital
RECRUITINGLondon, England, W1T 7HA, United Kingdom
Contact Phone: •••-•••-••••
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University of Alabama at Birmingham
RECRUITINGBirmingham, Alabama, 35294, United States
Contact Phone: •••-•••-••••
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University of Texas MD Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
Contact Phone: •••-•••-••••
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Yale New Haven Hospital-Smilow Cancer Center
RECRUITINGNew Haven, Connecticut, 06510, United States
Contact Phone: •••-•••-••••