New chemo cocktail aims to tame tough childhood kidney cancer

NCT ID NCT05384821

Recruiting now Disease control Sponsor: Centre Oscar Lambret Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a combination of five chemotherapy drugs given in a low-dose, frequent schedule (metronomic chemo) for children aged 1.5 to 17 years whose Wilms tumor has returned or not responded to at least two prior treatments. The goal is to see if this approach can stop the tumor from growing after two cycles. The trial is currently recruiting 28 participants across multiple centers.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: combination chemotherapy (vincristine, irinotecan, temozolomide, etoposide, cis-retinoic acid)
What this could lead to: If it works, this could offer a new treatment option to control Wilms tumor that has come back or not responded to standard therapy.
What could go wrong: This is an early-phase trial with only 28 participants, so results may not apply broadly. The combination of drugs may cause significant side effects and may not control the tumor.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

kidney cancer Wilms tumor

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

WILMS TUMOR

Contacts and locations

Locations

CHRU NANCY - Hôpital d'Enfants
RECRUITING

Vandœuvre-lès-Nancy, 54500, France
CHRU Strasbourg - Hôpital de Hautepierre
RECRUITING

Strasbourg, 67098, France
CHRU de Bordeaux Hôpital des Enfants
RECRUITING

Bordeaux, 33076, France
CHU Amiens Picardie
NOT_YET_RECRUITING

Amiens, 80054, France
CHU GRENOBLE ALPES - Hôpital COUPLE ENFANT
RECRUITING

Grenoble, 38043, France
CHU Hôpital Sud
RECRUITING

Rennes, 35203, France
CHU La Réunion
NOT_YET_RECRUITING

Saint-Denis, France
CHU Nantes
RECRUITING

Nantes, 44093, France
CHU Toulouse - Hôpital des Enfants
RECRUITING

Toulouse, 70034, France
CHU de Besancon
RECRUITING

Besançon, France
CHU de MONTPELLIER - Hôpital Arnaud de Villeneuve
NOT_YET_RECRUITING

Montpellier, 34295, France
CHU de Nice - Hôpital Archet 2
RECRUITING

Nice, 06202, France
Centre Léon Bérard
RECRUITING

Lyon, 69373, France
Centre Oscar Lambret
RECRUITING

Lille, 59020, France
Chu Rouen
RECRUITING

Rouen, 76000, France
Gustave ROUSSY
RECRUITING

Villejuif, 94805, France
Hôpital Armand-TROUSSEAU
RECRUITING

Paris, 75012, France
Hôpital pour Enfants " La Timone " AP-HM
RECRUITING

Marseille, 13005, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.