New chemo cocktail aims to tame tough childhood kidney cancer
NCT ID NCT05384821
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a combination of five chemotherapy drugs given in a low-dose, frequent schedule (metronomic chemo) for children aged 1.5 to 17 years whose Wilms tumor has returned or not responded to at least two prior treatments. The goal is to see if this approach can stop the tumor from growing after two cycles. The trial is currently recruiting 28 participants across multiple centers.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
combination chemotherapy (vincristine, irinotecan, temozolomide, etoposide, cis-retinoic acid)
What this could lead to
If it works, this could offer a new treatment option to control Wilms tumor that has come back or not responded to standard therapy.
What could go wrong
This is an early-phase trial with only 28 participants, so results may not apply broadly. The combination of drugs may cause significant side effects and may not control the tumor.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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CHRU NANCY - Hôpital d'Enfants
RECRUITINGVandœuvre-lès-Nancy, 54500, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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CHRU Strasbourg - Hôpital de Hautepierre
RECRUITINGStrasbourg, 67098, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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CHRU de Bordeaux Hôpital des Enfants
RECRUITINGBordeaux, 33076, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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CHU Amiens Picardie
NOT_YET_RECRUITINGAmiens, 80054, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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CHU GRENOBLE ALPES - Hôpital COUPLE ENFANT
RECRUITINGGrenoble, 38043, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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CHU Hôpital Sud
RECRUITINGRennes, 35203, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHU La Réunion
NOT_YET_RECRUITINGSaint-Denis, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHU Nantes
RECRUITINGNantes, 44093, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHU Toulouse - Hôpital des Enfants
RECRUITINGToulouse, 70034, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHU de Besancon
RECRUITINGBesançon, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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CHU de MONTPELLIER - Hôpital Arnaud de Villeneuve
NOT_YET_RECRUITINGMontpellier, 34295, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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CHU de Nice - Hôpital Archet 2
RECRUITINGNice, 06202, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Centre Léon Bérard
RECRUITINGLyon, 69373, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Centre Oscar Lambret
RECRUITINGLille, 59020, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Chu Rouen
RECRUITINGRouen, 76000, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Gustave ROUSSY
RECRUITINGVillejuif, 94805, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Hôpital Armand-TROUSSEAU
RECRUITINGParis, 75012, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Hôpital pour Enfants " La Timone " AP-HM
RECRUITINGMarseille, 13005, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact