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Gum fluid protein may reveal hidden implant inflammation

NCT ID NCT07697729

Knowledge-focused Sponsor: Ataturk University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
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Status unknown
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First seen Jul 13, 2026 · Last updated Sep 04, 2026 · Updated 3 times

Summary

This study investigates whether a protein called Metrnl, found in the fluid around dental implants, could serve as a biological marker for peri-implantitis—a condition that causes inflammation and bone loss around implants. Researchers will compare Metrnl levels and other inflammatory markers in people with healthy implants versus those with peri-implantitis. The goal is to see if Metrnl can help distinguish between healthy and diseased implants, potentially leading to earlier and more accurate diagnosis.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If Metrnl proves to be a reliable marker, it could lead to a simple, non-invasive test to detect peri-implantitis earlier and monitor treatment.
What could go wrong
This is a small observational study, not a treatment trial. The findings may not translate into a practical diagnostic tool, and Metrnl may not be specific enough to distinguish disease from health.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

68 people

The number who actually took part.

Started

Jul 2026

Finished

Aug 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population will consist of adults with at least one functioning dental implant who are evaluated at the Department of Periodontology, Faculty of Dentistry, Atatürk University. Participants will be classified into two groups according to clinical and radiographic findings: individuals with peri-implantitis and individuals with peri-implant health. Peri-implant clinical parameters and peri-implant crevicular fluid biomarker levels will be evaluated and compared between the groups.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Individuals aged 18 years or older * Individuals without systemic disease * Individuals with at least one healthy implant or one implant affected by peri-implantitis * At least 1 year having elapsed since placement of the prosthetic restoration on the relevant implant Exclusion Criteria: * Pregnant or lactating individuals. * Current smokers. * Use of antibiotics or corticosteroids within the previous 6 months. * Presence of an implant-supported removable prosthesis. * Periodontal or peri-implant treatment within the previous 6 months.

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Conditions

The condition(s) this trial relates to.

Peri-Implantitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Peri-implantitis

Contacts and locations

Locations

  • Atatürk University

    Erzurum, Erzurum, 25080, Turkey (Türkiye)

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