One shot before surgery could slash opioid need after knee replacement
NCT ID NCT07485803
First seen Mar 20, 2026 · Last updated May 02, 2026 · Updated 3 times
Summary
This study tests whether giving one dose of IV methadone right before total knee replacement surgery helps control pain afterward and lowers the amount of painkillers patients need. About 192 adults aged 21-75 having a knee replacement will take part. Researchers will track pain levels and opioid use for 48 hours after surgery.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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