Diabetes drug tested as potential new weapon against inherited ALS

This study is testing whether metformin, a common diabetes medication, is safe and tolerable for people with a specific genetic form of ALS caused by a C9orf72 mutation. Researchers want to see if taking metformin for 24 weeks can reduce levels of harmful proteins in the brain and spinal fluid that are thought to drive the disease. The trial involves 41 participants who already have a diagnosis of C9orf72 ALS and are currently taking or have taken metformin.