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Changes in serum IGF-1 levels with resistance exercises in patients with knee osteoarthritis and their association with clinical and radiological parameters

NCT ID NCT07890155

NEW Sponsor: Sisli Hamidiye Etfal Training and Research Hospital Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
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Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
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Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Oct 22, 2026 · Last updated Oct 22, 2026

Summary

The goal of this clinical trial is to evaluate the effects of a resistance exercise program on serum Insulin-like Growth Factor 1 (IGF-1) levels in patients with knee osteoarthritis. Specifically, it aims to investigate the relationship between changes in serum IGF-1 levels and clinical improvement after exercise therapy, and to evaluate the impact of the presence of osteoarthritis metabolic phenotype on this relationship. Participants will be asked to complete a structured resistance exercise program for 8 weeks. Researchers will compare the pre-exercise and post-exercise serum IGF-1 levels, clinical scores (WOMAC, VAS) and radiological findings (MOAKS Osteophyte Score) to determine the effectiveness of the intervention.

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Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 86 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2026

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosis of knee osteoarthritis according to the American College of Rheumatology (ACR) clinical and radiographic criteria. * Radiological severity of Kellgren-Lawrence (KL) grade 2 or 3 on standing anteroposterior knee radiographs * Having a knee magnetic resonance imaging (MRI) scan obtained within the past 1 year * Age between 40 and 75 years * Volunteering to participate in the study and signing the informed consent form Exclusion Criteria: * Receiving intra-articular injections (e.g., corticosteroids, hyaluronic acid, PRP) in the affected knee within the last 6 months * History of previous major knee surgery, knee arthroplasty, or lower extremity trauma affecting biomechanics * Diagnosis of rheumatoid arthritis, or other inflammatory joint diseases * Presence of severe cardiovascular, neurological, or musculoskeletal disorders that would contraindicate or prevent participation in a structured resistance exercise program * History of malignancy or presence of active malignancy * Presence of active infection * Cognitive impairment or inability to understand and follow the exercise instructions and questionnaires

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Conditions

The condition(s) this trial relates to.

abdominal obesity-metabolic syndrome metabolic syndrome X osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Metabolic syndrome (METS) Osteoarthritis, knee

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Sisli Hamidiye Etfal Training and Research Hospital

    RECRUITING

    Istanbul, Istanbul, 34396, Turkey (Türkiye)

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