New hope for advanced breast cancer: first human trial of MEN2312 begins

NCT ID NCT06638307

Recruiting now Disease control Sponsor: Stemline Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 2 times

Summary

This early-stage trial tests a new drug called MEN2312, alone or with another drug (elacestrant), in 240 adults with advanced breast cancer that has specific genetic changes. The main goals are to find a safe dose and check for side effects. It is the first time MEN2312 is being tested in humans.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: MEN2312 (a KAT6 inhibitor) and elacestrant
What this could lead to: If successful, this could point toward a new treatment option for advanced breast cancer with specific genetic changes.
What could go wrong: This is an early Phase 1 trial, so safety and dosing are still being tested. It may not lead to an effective treatment, and side effects are unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast cancer breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED BREAST CANCER

Contacts and locations

Locations

Advent Health Orlando
RECRUITING

Altamonte Springs, Florida, 32701, United States
Astera Cancer Care
RECRUITING

East Brunswick, New Jersey, 08816, United States
City of Hope
RECRUITING

Duarte, California, 31010, United States
Dana-Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Florida Cancer Specialists & Research Institute (FCS) - Sarasota
RECRUITING

Sarasota, Florida, 34232, United States
Froedtert Hospital & the Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Highlands Oncology Group
RECRUITING

Springdale, Arkansas, 72703, United States
Hospital Clinico San Carlos
RECRUITING

Madrid, 484816, Spain
Hospital Clinico Universitario De Valencia Oncologia Medica
RECRUITING

Valencia, 46010, Spain
Hospital Universitario 12 Octubre Servico de Oncologia Medica
RECRUITING

Madrid, 28041, Spain
Hospital Universitario Vall d'Hebron - Vall d'Hebron Institute of Oncology (VHIO) Medical Oncology Department
RECRUITING

Barcelona, 08035, Spain
Hospital Universitario y Politecnico La Fe Oncologia Medica
RECRUITING

Valencia, 46026, Spain
IOB - Madrid Fundacion Hermanas Hospitalarias (Hospital Beata Maria Ana)
RECRUITING

Madrid, 28007, Spain
Laura & Isaac Perlmutter Cancer Center at NYU Langone Health
RECRUITING

New York, New York, 10016, United States
Massachusetts General Hospital Cancer Center
RECRUITING

Boston, Massachusetts, 02114, United States
Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Moffitt Cancer Center
RECRUITING

Tampa, Florida, 33612, United States
NEXT Virginia
RECRUITING

Fairfax, Virginia, 22031, United States
Perlmutter Cancer Center - Sunset Park
RECRUITING

Brooklyn, New York, 11220, United States
Perlmutter Cancer Center at NYU Langone Hospital - Long Island
RECRUITING

Mineola, New York, 11501, United States
Providence Cancer Institute Franz Clinic
RECRUITING

Portland, Oregon, 97213, United States
SCRI Oncology Partners Group
RECRUITING

Nashville, Tennessee, 37203, United States
START Madrid - Centro Integral Oncologico Clara Campal (CIOCC), Hospital HM Sanchinarro
RECRUITING

Madrid, 28050, Spain
START Madrid - Hospital Universitario Fundacion Jimenez Diaz
RECRUITING

Madrid, 28040, Spain
START Midwest - Oncology
RECRUITING

Grand Rapids, Michigan, 49546, United States
START Mountain
RECRUITING

West Valley City, Utah, 84119, United States
START San Antonio, LLC
RECRUITING

San Antonio, Texas, 78229, United States
Sarah Cannon Research Institute at Florida Cancer Specialists
RECRUITING

Orlando, Florida, 32827, United States
Sidney Kimmel Comprehensive Cancer Center
RECRUITING

Baltimore, Maryland, 21287, United States
Stanford Cancer Center
RECRUITING

Palo Alto, California, 94304, United States
The University of Kansas Cancer Center
RECRUITING

Fairway, Kansas, 66205, United States
The University of Texas M.D. Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
The West Clinic, PC dba West Cancer Center
RECRUITING

Germantown, Tennessee, 38138, United States
UC San Diego Moores Cancer Center
RECRUITING

La Jolla, California, 92093-0698, United States
UCLA Hematology Oncology - Parkside
RECRUITING

Santa Monica, California, 90404, United States
UCSF Helen Diller Family Comprehensive Cancer Center
RECRUITING

San Francisco, California, 94158, United States
University of Chicago Medical Center
RECRUITING

Chicago, Illinois, 60637, United States
University of Illinois Hospital and Health Sciences System (Outpatient Cancer Center)
RECRUITING

Chicago, Illinois, 60612, United States
University of Iowa Health Care
RECRUITING

Iowa City, Iowa, 52242, United States
University of Texas Health Science Center San Antonio
RECRUITING

San Antonio, Texas, 78229, United States
University of Texas Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States
University of Wisconsin Carbone Cancer Center
RECRUITING

Madison, Wisconsin, 53792, United States
Winship Cancer Institute, Emory University
RECRUITING

Atlanta, Georgia, 30322, United States
Yale Comprehensive Cancer Center
RECRUITING

New Haven, Connecticut, 06511, United States

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