Sleep hormone melatonin tested as new melasma treatment

NCT ID NCT07169383

ENROLLING_BY_INVITATION Disease control Sponsor: Hina Malik Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests if a daily melatonin pill can treat melasma better than tranexamic acid, a standard treatment. 160 adults with melasma will take either melatonin or tranexamic acid for 3 months. Doctors will measure skin improvement using a standard score. The goal is to see if melatonin, known for its antioxidant effects, is more effective and easier to tolerate.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: melatonin tablet and tranexamic acid tablet
What this could lead to: If melatonin works better, it could offer a new, well-tolerated treatment option for melasma, a persistent skin condition.
What could go wrong: This is a small Phase 2 trial with 160 people. Results may not apply to everyone, and melatonin may not prove more effective than the current treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Melanosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MELASMA (FACIAL MELASMA)

Contacts and locations

Locations

PAEC General Hospital Islamabad Pakistan

Islamabad, Punjab Province, 44000, Pakistan

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