Sleep hormone melatonin tested as new melasma treatment
NCT ID NCT07169383
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tests if a daily melatonin pill can treat melasma better than tranexamic acid, a standard treatment. 160 adults with melasma will take either melatonin or tranexamic acid for 3 months. Doctors will measure skin improvement using a standard score. The goal is to see if melatonin, known for its antioxidant effects, is more effective and easier to tolerate.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
melatonin tablet and tranexamic acid tablet
What this could lead to
If melatonin works better, it could offer a new, well-tolerated treatment option for melasma, a persistent skin condition.
What could go wrong
This is a small Phase 2 trial with 160 people. Results may not apply to everyone, and melatonin may not prove more effective than the current treatment.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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PAEC General Hospital Islamabad Pakistan
Islamabad, Punjab Province, 44000, Pakistan