Cure My Disease

Don't miss your cure!

 Log in / Sign up

Could a sleep hormone gel help dental implants stick?

NCT ID NCT07869030

Symptom relief Sponsor: Future University in Egypt Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Oct 09, 2026 · Last updated Oct 16, 2026 · Updated 2 times

Summary

Researchers are testing whether a gel containing melatonin, a hormone linked to sleep, can help bone heal around dental implants placed right after a tooth is removed. The trial enrolls 16 adults who need an implant in the back of the lower jaw. Half receive the melatonin gel in the socket gap during surgery, and half receive standard implant placement. The team measures changes in bone density and bone thickness on scans, plus implant stability, to see if the gel shows promise for larger studies.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
A topical gel containing 1% melatonin, applied into the gap around a dental implant
What this could lead to
If it works, melatonin gel could become a simple, low-cost way to help bone heal around dental implants and reduce the need for extra bone grafting.
What could go wrong
This is a small pilot study with 16 people, so any hint of benefit may not hold up in larger trials. Melatonin gel might not make a measurable difference, and placing an implant right after a tooth extraction carries usual risks like infection or implant failure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 16 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2025

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 50 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged 20-50 years. * Indicated for extraction and immediate implant placement in the posterior mandibular molar region. * Good oral hygiene and compliance with postoperative instructions. * Non-smokers or light smokers (≤10 cigarettes/day). * Patients who provide written informed consent and agree to attend follow-up visits. Exclusion Criteria: * Patients with systemic diseases affecting bone metabolism or wound healing (e.g., uncontrolled diabetes, osteoporosis). * Heavy smokers (\>10 cigarettes/day). * History of head and neck radiotherapy or chemotherapy. * Pregnant or lactating women. * Sites with acute infection, cystic lesions, or pathology. * Bruxism or parafunctional habits. * Use of medications affecting bone turnover (e.g., bisphosphonates, corticosteroids). * Poor compliance or unwillingness to return for follow-up visits.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Alveolar bone loss are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Alveolar Bone Loss periodontal disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Alveolar bone loss Bone density Dental implant Immediate dental implant placement Osseointegration

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Department of Oral and Maxillofacial Surgery, Faculty of Oral and Dental Medicine - Future University in Egypt

    RECRUITING

    Cairo, 43528, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.