Immunotherapy combo shows promise in stopping melanoma recurrence after surgery

NCT ID NCT04013854

First seen Nov 06, 2025 · Last updated May 08, 2026 · Updated 21 times

Summary

This study tests whether giving immunotherapy drugs (nivolumab alone or with ipilimumab) after melanoma surgery can prevent the cancer from coming back. 67 adults with stage III melanoma that can be removed by surgery will receive one dose of nivolumab before surgery, then continue treatment for up to a year based on how their tumor responded. The goal is to see if this approach improves recurrence-free survival.

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Contacts and locations

Locations

  • Abramson Cancer Center, University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

  • Duke Cancer Institute

    Durham, North Carolina, 27710, United States

  • Lancaster General Hospital

    Lancaster, Pennsylvania, 17601, United States

Conditions

Explore the condition pages connected to this study.