Can targeted exercises unpinch nerves and ease thoracic outlet syndrome?
NCT ID NCT07785427
First seen Aug 25, 2026 · Last updated Aug 26, 2026 · Updated 1 time
Summary
This trial tests whether a specific physical therapy approach—mechanically loaded neuro-dynamics—can ease symptoms of thoracic outlet syndrome, a condition where nerves or blood vessels get compressed near the collarbone. About 36 adults with the condition will follow an 11-week exercise program using resistance bands, with intensity gradually increasing. Researchers will measure changes in pain, neck and shoulder range of motion, nerve function, and quality of life to see if this therapy helps.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Mechanically loaded neuro-dynamics, a physical therapy exercise protocol using resistance bands
- What this could lead to
- If effective, this exercise approach could offer a non-surgical way to reduce pain, improve shoulder and neck movement, and boost quality of life for people with thoracic outlet syndrome.
- What could go wrong
- This is a small, early-stage trial, so results may not apply broadly. The exercises involve progressive loading, which could temporarily increase symptoms if not carefully monitored.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 36 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Sep 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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24 to 37 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Subjects from both genders diagnosed with Thoracic Outlet Syndrome will be recruited through direct referrals from their neurosurgeon. 2. Subjects age between 30.8±7.4 years 3. Subjects body mass index = 19.5±2.8 4. Control group includes health volunteer subjects with negative root test results under supervision of neurosurgeon. Exclusion Criteria: The exclusion criteria are: 1. head injury, stroke. 2. epilepsy episodes. 3. mental disorders. 4. cardiovascular disease. 5. having a pacemaker or cochlear implant. 6. pregnancy, oncological episodes, inflammatory disease, myelopathy, degenerative changes in the cervical spine (after verification on computed tomography or magnetic resonance imaging scans). 7. peripheral neuropathies from the level of the arm and COVID-19-related symptoms
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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out-patient clinic, faculty of physical therapy - Kafrelsheikh University.
Kafr ash Shaykh, Egypt
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Other studies related to the condition(s) this trial covers.
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- Five years after surgery: how do patients with thoracic outlet syndrome really fare?