Immunotherapy duo aims to boost lung cancer cure rates before surgery

NCT ID NCT05742607

Recruiting now Disease control Sponsor: Innate Pharma Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial is testing whether adding two immunotherapy drugs, IPH5201 and durvalumab, to standard chemotherapy before and after surgery can improve outcomes for people with early-stage (stage II to III) non-small cell lung cancer. The study includes two groups: one receiving the combination both before and after surgery, and another receiving it only before surgery. The main goals are to see how many patients have no cancer cells left after treatment and to monitor side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

IPH5201 and durvalumab (immunotherapy drugs) plus standard chemotherapy

What this could lead to

If successful, this combination could improve the chance of eliminating lung cancer before surgery and reduce the risk of it returning afterward.

What could go wrong

This is a mid-stage trial with only 70 participants, so results may not apply to all patients. Immunotherapy can cause serious immune-related side effects.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SMALL-CELL LUNG CANCER

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Angers University Hospital Center
TERMINATED

Angers, 49333, France
CHU de Limoges
RECRUITING

Limoges, 87042, France

Contact
Charles Nicolle Hospital
TERMINATED

Rouen, 76031, France
Eugenia and Janusz Zeyland Wielkopolskie Centre of Pulmonology and Thoracic Surgery
TERMINATED

Poznan, 60-569, Poland
Gustave Roussy
RECRUITING

Villejuif, 94805, France

Contact
H. Lee Moffitt Cancer Center & Research Institute
TERMINATED

Tampa, Florida, 33612, United States
Henry Dunant Hospital Center
WITHDRAWN

Athens, 11526, Greece
Hospital Calmette
NOT_YET_RECRUITING

Lille, 59037, France

Contact
Jasz-Nagykun-Szolnok County Hetenyi Geza Hospital-Clinic, Department of Oncology
RECRUITING

Szolnok, H-5000, Hungary

Contact
John Paul II Specialist Hospital in Krakow
TERMINATED

Krąków, 31-202, Poland
Koranyi National Institute of Pulmonology, 14th Department of Pulmonology
RECRUITING

Budapest, H-1121, Hungary

Contact
Leon Berard Center
RECRUITING

Lyon, 69373, France

Contact
Mandziuk Slawomir - Specialist Medical Practice
TERMINATED

Lublin, 20-093, Poland
Marseille University Hospital Center - North Hospital
RECRUITING

Marseille, 13015, France

Contact
Military Institute of Medicine - National Research Institute
TERMINATED

Warsaw, 04-141, Poland
Millennium Research & Clinical Development
TERMINATED

Houston, Texas, 77090, United States
Northwell Health Cancer Institute / Center for Novel Cancer Therapeutics
WITHDRAWN

Lake Success, New York, 11042, United States
Petz Aladar University Teaching Hospital, Department of Pulmonology
TERMINATED

Győr, 9024, Hungary
Pulmonology Institute Torokbalint
NOT_YET_RECRUITING

Törökbálint, H-2045, Hungary

Contact
Rennes University Hospital Center - Hospital Pontchaillou
RECRUITING

Rennes, 35033, France

Contact
Specialist Hospital in Prabuty Sp. z o.o. (LLC)
RECRUITING

Prabuty, 82-550, Poland

Contact
St. Anthony's Hospital - BayCare Health System
TERMINATED

St. Petersburg, Florida, 33705, United States
UW Carbone Cancer Center - Cancer Connect
TERMINATED

Madison, Wisconsin, 53792, United States
University General Hospital "Attikon"
RECRUITING

Athens, 12462, Greece

Contact
University General Hospital of Ioannina
TERMINATED

Ioannina, 45500, Greece
University General Hospital of Patras
TERMINATED

Pátrai, 26504, Greece
University Hospital Center Caen
TERMINATED

Caen, 14033, France
University Teaching Hospital in Bialystok, 2nd Department of Lung Diseases and Tuberculosis
RECRUITING

Bialystok, 15-540, Poland

Contact
University of Chicago Medical Center
WITHDRAWN

Chicago, Illinois, 60637, United States
Veszprem County Pulmonology Institute
TERMINATED

Farkasgyepű, 8582, Hungary