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Immunotherapy duo aims to boost lung cancer cure rates before surgery

NCT ID NCT05742607

Recruiting now Disease control Sponsor: Innate Pharma Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial is testing whether adding two immunotherapy drugs, IPH5201 and durvalumab, to standard chemotherapy before and after surgery can improve outcomes for people with early-stage (stage II to III) non-small cell lung cancer. The study includes two groups: one receiving the combination both before and after surgery, and another receiving it only before surgery. The main goals are to see how many patients have no cancer cells left after treatment and to monitor side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
IPH5201 and durvalumab (immunotherapy drugs) plus standard chemotherapy
What this could lead to
If successful, this combination could improve the chance of eliminating lung cancer before surgery and reduce the risk of it returning afterward.
What could go wrong
This is a mid-stage trial with only 70 participants, so results may not apply to all patients. Immunotherapy can cause serious immune-related side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SMALL CELL LUNG CANCER

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Angers University Hospital Center

    TERMINATED

    Angers, 49333, France

  • CHU de Limoges

    RECRUITING

    Limoges, 87042, France

  • Charles Nicolle Hospital

    TERMINATED

    Rouen, 76031, France

  • Eugenia and Janusz Zeyland Wielkopolskie Centre of Pulmonology and Thoracic Surgery

    TERMINATED

    Poznan, 60-569, Poland

  • Gustave Roussy

    RECRUITING

    Villejuif, 94805, France

  • H. Lee Moffitt Cancer Center & Research Institute

    TERMINATED

    Tampa, Florida, 33612, United States

  • Henry Dunant Hospital Center

    WITHDRAWN

    Athens, 11526, Greece

  • Hospital Calmette

    NOT_YET_RECRUITING

    Lille, 59037, France

  • Jasz-Nagykun-Szolnok County Hetenyi Geza Hospital-Clinic, Department of Oncology

    RECRUITING

    Szolnok, H-5000, Hungary

  • John Paul II Specialist Hospital in Krakow

    TERMINATED

    Krąków, 31-202, Poland

  • Koranyi National Institute of Pulmonology, 14th Department of Pulmonology

    RECRUITING

    Budapest, H-1121, Hungary

  • Leon Berard Center

    RECRUITING

    Lyon, 69373, France

  • Mandziuk Slawomir - Specialist Medical Practice

    TERMINATED

    Lublin, 20-093, Poland

  • Marseille University Hospital Center - North Hospital

    RECRUITING

    Marseille, 13015, France

  • Military Institute of Medicine - National Research Institute

    TERMINATED

    Warsaw, 04-141, Poland

  • Millennium Research & Clinical Development

    TERMINATED

    Houston, Texas, 77090, United States

  • Northwell Health Cancer Institute / Center for Novel Cancer Therapeutics

    WITHDRAWN

    Lake Success, New York, 11042, United States

  • Petz Aladar University Teaching Hospital, Department of Pulmonology

    TERMINATED

    Győr, 9024, Hungary

  • Pulmonology Institute Torokbalint

    NOT_YET_RECRUITING

    Törökbálint, H-2045, Hungary

  • Rennes University Hospital Center - Hospital Pontchaillou

    RECRUITING

    Rennes, 35033, France

  • Specialist Hospital in Prabuty Sp. z o.o. (LLC)

    RECRUITING

    Prabuty, 82-550, Poland

  • St. Anthony's Hospital - BayCare Health System

    TERMINATED

    St. Petersburg, Florida, 33705, United States

  • UW Carbone Cancer Center - Cancer Connect

    TERMINATED

    Madison, Wisconsin, 53792, United States

  • University General Hospital "Attikon"

    RECRUITING

    Athens, 12462, Greece

  • University General Hospital of Ioannina

    TERMINATED

    Ioannina, 45500, Greece

  • University General Hospital of Patras

    TERMINATED

    Pátrai, 26504, Greece

  • University Hospital Center Caen

    TERMINATED

    Caen, 14033, France

  • University Teaching Hospital in Bialystok, 2nd Department of Lung Diseases and Tuberculosis

    RECRUITING

    Bialystok, 15-540, Poland

  • University of Chicago Medical Center

    WITHDRAWN

    Chicago, Illinois, 60637, United States

  • Veszprem County Pulmonology Institute

    TERMINATED

    Farkasgyepű, 8582, Hungary

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