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New hope for marginal zone lymphoma: Chemo-Free combo shows promise

NCT ID NCT03697512

Ongoing Disease control Sponsor: International Extranodal Lymphoma Study Group (IELSG) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase II trial tests a combination of two drugs, ibrutinib and rituximab, in people with untreated marginal zone lymphoma, a rare blood cancer. The study aims to see how many patients achieve complete remission after one year and how long they stay cancer-free. About 175 participants will receive the treatment, and researchers will also monitor side effects closely.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
ibrutinib and rituximab
What this could lead to
If successful, this combination could offer a new first-line treatment option for marginal zone lymphoma, potentially improving long-term disease control without chemotherapy.
What could go wrong
This is a single-arm phase II trial with no placebo group, so results are preliminary. Side effects from ibrutinib and rituximab can include infections, bleeding, and infusion reactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Lymphoma, B-Cell, Marginal Zone MALT lymphoma marginal zone lymphoma nodal marginal zone B-cell lymphoma splenic marginal zone lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MARGINAL ZONE LYMPHOMA NODAL MARGINAL ZONE LYMPHOMA SPLENIC MARGINAL ZONE LYMPHOMA

Contacts and locations

Locations

  • A.O. Spedali Civili di Brescia

    Brescia, 25123, Italy

  • A.O.U. Città della Salute e della Scienza di Torino Ospedale Molinette

    Torino, TO, 10126, Italy

  • AAST Grande Ospedale Metropolitano Niguarda

    Milan, 20162, Italy

  • Azienda Ospedaliera Arcispedale Santa Maria Nuova IRCCS

    Reggio Emilia, 42123, Italy

  • Azienda Ospedaliera Universitaria Ospedali Riuniti - Università Politecnica delle Marche

    Ancona, 60100, Italy

  • Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI)

    Trieste, Italy

  • CHRU de Strasbourg

    Strasbourg, 67091, France

  • CHU Dijon Bourgogne - Hôpital François Mitterand

    Dijon, 21000, France

  • CHU UCL Namur / site Godinne

    Yvoir, B5530, Belgium

  • CHU d'Estaing

    Clermont-Ferrand, Cedex 1, 63003, France

  • CHU de Grenoble - Hôpital Albert MICHALLON

    La Tronche, 38700, France

  • CHU de Montpellier

    Montpellier, Cedex 05, 34295, France

  • CHU de Nancy - Hôpital Brabois

    Vandœuvre-lès-Nancy, 54500, France

  • CHU de Rennes Pontchaillou

    Rennes, Cedex 9, 35033, France

  • CHU de Tours - Hôpital Bretonneau

    Tours, Cedex 01, 37004, France

  • Centre Hospitalier Lyon Sud

    Pierre-Bénite, 69495, France

  • Fondazione IRCCS - Cà Granda - Ospedale Maggiore Policlinico

    Milan, 20122, Italy

  • Fondazione IRCCS - Istituto Nazionale dei Tumori

    Milan, 20133, Italy

  • Fondazione IRCCS - Policlinico San Matteo

    Pavia, 27100, Italy

  • Giovanni Paolo II/I.R.C.C.S. Istituto Tumori

    Bari, 70124, Italy

  • Hôpitaux Universitaires de Genève

    Geneva, 1211, Switzerland

  • IHBN - CHU Côte de Nacre

    Caen, 14033, France

  • IUCT Oncopole Toulouse

    Toulouse, 31100, France

  • Inselspital Bern

    Bern, 3010, Switzerland

  • Institut Bergonié

    Bordeaux, 33076, France

  • Instituto Português de Oncologia de Lisboa Francisco Gentil, E.P.E.

    Lisbon, 1099-023, Portugal

  • Istituto Oncologico della Svizzera Italiana (IOSI)

    Bellinzona, Canton Ticino, 6500, Switzerland

  • Kantonalspital Baden

    Baden, 5404, Switzerland

  • Ospedale Oncologico Businco

    Cagliari, 09121, Italy

  • Ospedale San Raffaele

    Milan, MI, 20132, Italy

  • Ospedale degli Infermi

    Ponderano, BI, 13875, Italy

  • Ospedale di Circolo e Fondazione Macchi di Varese

    Varese, 21100, Italy

  • Saint Louis Hospital

    Paris, 75010, France

  • U.O. Ematologia AUSL Ravenna

    Ravenna, 48121, Italy

  • Università degli Studi di Roma La Sapienza

    Roma, 00185, Italy

  • Universitätsspital Zürich

    Zurich, 8091, Switzerland

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