New hope for marginal zone lymphoma: Chemo-Free combo shows promise
NCT ID NCT03697512
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase II trial tests a combination of two drugs, ibrutinib and rituximab, in people with untreated marginal zone lymphoma, a rare blood cancer. The study aims to see how many patients achieve complete remission after one year and how long they stay cancer-free. About 175 participants will receive the treatment, and researchers will also monitor side effects closely.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ibrutinib and rituximab
What this could lead to
If successful, this combination could offer a new first-line treatment option for marginal zone lymphoma, potentially improving long-term disease control without chemotherapy.
What could go wrong
This is a single-arm phase II trial with no placebo group, so results are preliminary. Side effects from ibrutinib and rituximab can include infections, bleeding, and infusion reactions.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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A.O. Spedali Civili di Brescia
Brescia, 25123, Italy
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A.O.U. Città della Salute e della Scienza di Torino Ospedale Molinette
Torino, TO, 10126, Italy
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AAST Grande Ospedale Metropolitano Niguarda
Milan, 20162, Italy
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Azienda Ospedaliera Arcispedale Santa Maria Nuova IRCCS
Reggio Emilia, 42123, Italy
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Azienda Ospedaliera Universitaria Ospedali Riuniti - Università Politecnica delle Marche
Ancona, 60100, Italy
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Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI)
Trieste, Italy
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CHRU de Strasbourg
Strasbourg, 67091, France
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CHU Dijon Bourgogne - Hôpital François Mitterand
Dijon, 21000, France
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CHU UCL Namur / site Godinne
Yvoir, B5530, Belgium
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CHU d'Estaing
Clermont-Ferrand, Cedex 1, 63003, France
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CHU de Grenoble - Hôpital Albert MICHALLON
La Tronche, 38700, France
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CHU de Montpellier
Montpellier, Cedex 05, 34295, France
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CHU de Nancy - Hôpital Brabois
Vandœuvre-lès-Nancy, 54500, France
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CHU de Rennes Pontchaillou
Rennes, Cedex 9, 35033, France
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CHU de Tours - Hôpital Bretonneau
Tours, Cedex 01, 37004, France
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Centre Hospitalier Lyon Sud
Pierre-Bénite, 69495, France
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Fondazione IRCCS - Cà Granda - Ospedale Maggiore Policlinico
Milan, 20122, Italy
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Fondazione IRCCS - Istituto Nazionale dei Tumori
Milan, 20133, Italy
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Fondazione IRCCS - Policlinico San Matteo
Pavia, 27100, Italy
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Giovanni Paolo II/I.R.C.C.S. Istituto Tumori
Bari, 70124, Italy
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Hôpitaux Universitaires de Genève
Geneva, 1211, Switzerland
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IHBN - CHU Côte de Nacre
Caen, 14033, France
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IUCT Oncopole Toulouse
Toulouse, 31100, France
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Inselspital Bern
Bern, 3010, Switzerland
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Institut Bergonié
Bordeaux, 33076, France
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Instituto Português de Oncologia de Lisboa Francisco Gentil, E.P.E.
Lisbon, 1099-023, Portugal
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Istituto Oncologico della Svizzera Italiana (IOSI)
Bellinzona, Canton Ticino, 6500, Switzerland
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Kantonalspital Baden
Baden, 5404, Switzerland
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Ospedale Oncologico Businco
Cagliari, 09121, Italy
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Ospedale San Raffaele
Milan, MI, 20132, Italy
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Ospedale degli Infermi
Ponderano, BI, 13875, Italy
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Ospedale di Circolo e Fondazione Macchi di Varese
Varese, 21100, Italy
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Saint Louis Hospital
Paris, 75010, France
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U.O. Ematologia AUSL Ravenna
Ravenna, 48121, Italy
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Università degli Studi di Roma La Sapienza
Roma, 00185, Italy
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Universitätsspital Zürich
Zurich, 8091, Switzerland